Limits...
Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery.

Bhatt H, Naik B, Dharamsi A - J Pharm (Cairo) (2014)

Bottom Line: Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release.The optimized batch from statistical design was kept under accelerated condition for three months.After accelerated stability study, there was no significant change in the drug release.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Pharmaceutical Education and Research (NIPER), B. V. Patel Pharmaceutical Education and Research Development (PERD), S G Highway, Thaltej, Ahmedabad 380054, India.

ABSTRACT
The purpose of the research was to present Budesonide (BUD) as a novel formulation showing improved aqueous solubility, which may decrease variability in C max⁡ and T max⁡ found in inflammatory bowel disease (IBD) patients, and drug targeting to colon. To improve aqueous solubility, solid dispersion (SD) of the BUD with poloxamer 188 was prepared by melting method. Physical characterization of solid dispersion was performed. The SD was used to prepare tablet equivalent to 9 mg of BUD. The tablet was coated with enteric polymers Eudragit S100 and Eudragit L100 to target colon. The ratio of polymers and percentage coating was optimized using statistical design. Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release. Dissolution at different pH showed that drug release in colon could be modified by optimizing the ratio of polymers and percentage coating. The dissolution data showed that the percentage coating and ratio of polymers are very important to get lag time and optimum formulation. The optimized batch from statistical design was kept under accelerated condition for three months. After accelerated stability study, there was no significant change in the drug release.

No MeSH data available.


Related in: MedlinePlus

In vitro release study of factorial batches.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4590827&req=5

fig4: In vitro release study of factorial batches.

Mentions: The factorial batches were prepared by using independent variables like ratio of Eudragit S100 and Eudragit L100 (X1) and % weight gain (coating) (X2) and to check its effect on dependent variables like Y1 and Y2. Factorial batches of Budesonide were evaluated for the in vitro drug release and by its regression analysis. The cumulative percentage of Budesonide release rate for all the formulations (B1 to B11) are shown in Figure 4.


Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery.

Bhatt H, Naik B, Dharamsi A - J Pharm (Cairo) (2014)

In vitro release study of factorial batches.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590827&req=5

fig4: In vitro release study of factorial batches.
Mentions: The factorial batches were prepared by using independent variables like ratio of Eudragit S100 and Eudragit L100 (X1) and % weight gain (coating) (X2) and to check its effect on dependent variables like Y1 and Y2. Factorial batches of Budesonide were evaluated for the in vitro drug release and by its regression analysis. The cumulative percentage of Budesonide release rate for all the formulations (B1 to B11) are shown in Figure 4.

Bottom Line: Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release.The optimized batch from statistical design was kept under accelerated condition for three months.After accelerated stability study, there was no significant change in the drug release.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Pharmaceutical Education and Research (NIPER), B. V. Patel Pharmaceutical Education and Research Development (PERD), S G Highway, Thaltej, Ahmedabad 380054, India.

ABSTRACT
The purpose of the research was to present Budesonide (BUD) as a novel formulation showing improved aqueous solubility, which may decrease variability in C max⁡ and T max⁡ found in inflammatory bowel disease (IBD) patients, and drug targeting to colon. To improve aqueous solubility, solid dispersion (SD) of the BUD with poloxamer 188 was prepared by melting method. Physical characterization of solid dispersion was performed. The SD was used to prepare tablet equivalent to 9 mg of BUD. The tablet was coated with enteric polymers Eudragit S100 and Eudragit L100 to target colon. The ratio of polymers and percentage coating was optimized using statistical design. Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release. Dissolution at different pH showed that drug release in colon could be modified by optimizing the ratio of polymers and percentage coating. The dissolution data showed that the percentage coating and ratio of polymers are very important to get lag time and optimum formulation. The optimized batch from statistical design was kept under accelerated condition for three months. After accelerated stability study, there was no significant change in the drug release.

No MeSH data available.


Related in: MedlinePlus