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Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy.

Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, Nalluri BN - J Pharm (Cairo) (2014)

Bottom Line: MDFs with PVP K30 and SLS gave superior dissolution properties when compared to MDFs without PVP K30 and SLS.The dissolution properties of MDFs with PVP K30 were superior when compared to MDFs with SLS.In the case of F3 containing 7.5% of HPMC E3 and 0.04% of PVP K30, complete and faster release was observed within 60 sec when compared to other formulations.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh 520010, India.

ABSTRACT
The present investigation was undertaken with an objective of formulating mouth dissolving films (MDFs) of Amlodipine Besylate (AMLO) to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy. Film formers like hydroxy propyl methyl cellulose (HPMC) and methyl cellulose (MC) along with film modifiers like poly vinyl pyrrolidone K30 (PVP K30), and sodium lauryl sulphate (SLS) as solubilizing agents were evaluated. The prepared MDFs were evaluated for in vitro dissolution characteristics, in vitro disintegration time, and their physicomechanical properties. All the prepared MDFs showed good mechanical properties like tensile strength, folding endurance, and % elongation. MDFs were evaluated by means of FTIR, SEM, and X-RD studies. MDFs with 7.5% (w/w) of HPMC E3 gave better dissolution properties when compared to HPMC E5, HPMC E15, and MC. MDFs with PVP K30 and SLS gave superior dissolution properties when compared to MDFs without PVP K30 and SLS. The dissolution properties of MDFs with PVP K30 were superior when compared to MDFs with SLS. In the case of F3 containing 7.5% of HPMC E3 and 0.04% of PVP K30, complete and faster release was observed within 60 sec when compared to other formulations. Release kinetics data reveals diffusion is the release mechanism.

No MeSH data available.


Related in: MedlinePlus

SEM photographs of pure AMLO (a); AMLO + HPMC E3 film (b); AMLO + HPMC E3 + SLS film (c); AMLO + HPMC E3 + PVP film (d); AMLO + HPMC E5 film (e); AMLO + HPMC E5 + SLS film (f); AMLO + HPMC E5 + PVP film (g); AMLO + HPMC E15 film (h); AMLO + HPMC E15 + SLS film (i); and AMLO + HPMC E15 + PVP film (j).
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fig4: SEM photographs of pure AMLO (a); AMLO + HPMC E3 film (b); AMLO + HPMC E3 + SLS film (c); AMLO + HPMC E3 + PVP film (d); AMLO + HPMC E5 film (e); AMLO + HPMC E5 + SLS film (f); AMLO + HPMC E5 + PVP film (g); AMLO + HPMC E15 film (h); AMLO + HPMC E15 + SLS film (i); and AMLO + HPMC E15 + PVP film (j).

Mentions: Macroscopically the prepared AMLO MDFs were clear and colorless. The scanning electron photomicrograph of the selected MDFs and also pure AMLO at 2500x magnification are shown in Figure 4. The SEM photographs of MDFs showed smooth surfaces without any scratches or transverse striations indicating that AMLO is uniformly distributed and no crystals of AMLO were observed in the MDFs.


Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy.

Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, Nalluri BN - J Pharm (Cairo) (2014)

SEM photographs of pure AMLO (a); AMLO + HPMC E3 film (b); AMLO + HPMC E3 + SLS film (c); AMLO + HPMC E3 + PVP film (d); AMLO + HPMC E5 film (e); AMLO + HPMC E5 + SLS film (f); AMLO + HPMC E5 + PVP film (g); AMLO + HPMC E15 film (h); AMLO + HPMC E15 + SLS film (i); and AMLO + HPMC E15 + PVP film (j).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
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fig4: SEM photographs of pure AMLO (a); AMLO + HPMC E3 film (b); AMLO + HPMC E3 + SLS film (c); AMLO + HPMC E3 + PVP film (d); AMLO + HPMC E5 film (e); AMLO + HPMC E5 + SLS film (f); AMLO + HPMC E5 + PVP film (g); AMLO + HPMC E15 film (h); AMLO + HPMC E15 + SLS film (i); and AMLO + HPMC E15 + PVP film (j).
Mentions: Macroscopically the prepared AMLO MDFs were clear and colorless. The scanning electron photomicrograph of the selected MDFs and also pure AMLO at 2500x magnification are shown in Figure 4. The SEM photographs of MDFs showed smooth surfaces without any scratches or transverse striations indicating that AMLO is uniformly distributed and no crystals of AMLO were observed in the MDFs.

Bottom Line: MDFs with PVP K30 and SLS gave superior dissolution properties when compared to MDFs without PVP K30 and SLS.The dissolution properties of MDFs with PVP K30 were superior when compared to MDFs with SLS.In the case of F3 containing 7.5% of HPMC E3 and 0.04% of PVP K30, complete and faster release was observed within 60 sec when compared to other formulations.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh 520010, India.

ABSTRACT
The present investigation was undertaken with an objective of formulating mouth dissolving films (MDFs) of Amlodipine Besylate (AMLO) to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy. Film formers like hydroxy propyl methyl cellulose (HPMC) and methyl cellulose (MC) along with film modifiers like poly vinyl pyrrolidone K30 (PVP K30), and sodium lauryl sulphate (SLS) as solubilizing agents were evaluated. The prepared MDFs were evaluated for in vitro dissolution characteristics, in vitro disintegration time, and their physicomechanical properties. All the prepared MDFs showed good mechanical properties like tensile strength, folding endurance, and % elongation. MDFs were evaluated by means of FTIR, SEM, and X-RD studies. MDFs with 7.5% (w/w) of HPMC E3 gave better dissolution properties when compared to HPMC E5, HPMC E15, and MC. MDFs with PVP K30 and SLS gave superior dissolution properties when compared to MDFs without PVP K30 and SLS. The dissolution properties of MDFs with PVP K30 were superior when compared to MDFs with SLS. In the case of F3 containing 7.5% of HPMC E3 and 0.04% of PVP K30, complete and faster release was observed within 60 sec when compared to other formulations. Release kinetics data reveals diffusion is the release mechanism.

No MeSH data available.


Related in: MedlinePlus