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Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels.

Sanaboina J, Maheswari KM, Sunkara S, Deekonda S, Nalluri BN - J Pharm (Cairo) (2013)

Bottom Line: The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra.Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics.From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Andhra Pradesh, Vijayawda 520010, India.

ABSTRACT
The present investigation includes the preparation of liquid filling formulations for soft gels using an antihypertensive drug, valsartan (VAL), in order to improve its dissolution properties and thereby its bioavailability. Formulations were prepared using excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), polyvinylpyrrolidone (PVP K-30), antioxidants, ethanol, and purified water. Prepared formulations were evaluated for appearance, pH, drug content percentage, viscosity, stability, and in vitro dissolution studies. The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra. The drug contents were in the range of 99.62-99.63 and the viscosity was in the range of 60.9-591.7 cps with all the formulations developed. Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics. Stability studies were conducted for selected formulations (F4-F9) for a period of 6 months at room temperature (~30°C/65% RH). From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.

No MeSH data available.


Comparative in vitro dissolution profile for F4, F8, and F9 (n = 3).
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fig5: Comparative in vitro dissolution profile for F4, F8, and F9 (n = 3).

Mentions: The increase in dissolution was observed for formulation F4 at 100 rpm when compared to 50 rpm. But the formulations F8 and F9 showed a complete dissolution within 10 min irrespective of speed. The comparative dissolution profile was shown in Figure 5. The initial increase in dissolution of formulations at 100 rpm was may be because of the miscibility of liquid filling formulations at higher rpm. Hence, the selection of appropriate rpm was important in the development of soft gel formulations.


Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels.

Sanaboina J, Maheswari KM, Sunkara S, Deekonda S, Nalluri BN - J Pharm (Cairo) (2013)

Comparative in vitro dissolution profile for F4, F8, and F9 (n = 3).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590804&req=5

fig5: Comparative in vitro dissolution profile for F4, F8, and F9 (n = 3).
Mentions: The increase in dissolution was observed for formulation F4 at 100 rpm when compared to 50 rpm. But the formulations F8 and F9 showed a complete dissolution within 10 min irrespective of speed. The comparative dissolution profile was shown in Figure 5. The initial increase in dissolution of formulations at 100 rpm was may be because of the miscibility of liquid filling formulations at higher rpm. Hence, the selection of appropriate rpm was important in the development of soft gel formulations.

Bottom Line: The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra.Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics.From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Andhra Pradesh, Vijayawda 520010, India.

ABSTRACT
The present investigation includes the preparation of liquid filling formulations for soft gels using an antihypertensive drug, valsartan (VAL), in order to improve its dissolution properties and thereby its bioavailability. Formulations were prepared using excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), polyvinylpyrrolidone (PVP K-30), antioxidants, ethanol, and purified water. Prepared formulations were evaluated for appearance, pH, drug content percentage, viscosity, stability, and in vitro dissolution studies. The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra. The drug contents were in the range of 99.62-99.63 and the viscosity was in the range of 60.9-591.7 cps with all the formulations developed. Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics. Stability studies were conducted for selected formulations (F4-F9) for a period of 6 months at room temperature (~30°C/65% RH). From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.

No MeSH data available.