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Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus

The FTIR of (a) budesonide, (b) formulated DPI, (c) chitosan, (d) sodium alginate, and (e) pluronic F-68.
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fig4: The FTIR of (a) budesonide, (b) formulated DPI, (c) chitosan, (d) sodium alginate, and (e) pluronic F-68.

Mentions: Potential intermolecular interactions between the polymers and drugs were analyzed by the FTIR spectra (Figure 4). Budesonide showed peaks at 3499 cm−1, 2956 cm−1, 1722 cm−1, and 1690 cm−1 due to O–H stretching, C–H stretching, and C=O stretching. The characteristic peaks of sodium alginate were observed at 3357 cm−1, 1601 to 1407 cm−1, and 1029 cm−1 due to hydroxyl group, COO− group, symmetric and asymmetric stretching vibrations, and C–O–C group stretching vibrations, respectively. Chitosan spectra showed peaks at 3414 cm−1, 1538 cm−1, 1402 cm−1, and 1101 cm−1 due to presence of N–H stretching of amine group and presence of secondary hydroxyl group. Pluronic F-68 showed functional group peak at 1154.19 cm−1. However, in the final spectrum of formulation, budesonide showed minor shifting of peaks to 3487 cm−1, 2971 cm−1, 1705 cm−1, and 1638 cm−1 for O–H stretching, C–H stretching, and C=O stretching. Minor shifting in the peaks of sodium alginate was observed at 3987 cm−1, 1638 cm−1 to 1562 cm−1, and 963 cm−1 for OH, COO−, and C–O–C groups, respectively. Furthermore, in chitosan, shifting of NH2 group, amide group, and N–H stretching and hydroxyl group was carried out to 3487 cm−1, 1467 cm−1, 1459 cm−1, and 1136 cm−1, respectively. This shifting of functional groups was attributed to the formation of hydrogen bonding and conversion to amorphous form [4, 39].


Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

The FTIR of (a) budesonide, (b) formulated DPI, (c) chitosan, (d) sodium alginate, and (e) pluronic F-68.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590799&req=5

fig4: The FTIR of (a) budesonide, (b) formulated DPI, (c) chitosan, (d) sodium alginate, and (e) pluronic F-68.
Mentions: Potential intermolecular interactions between the polymers and drugs were analyzed by the FTIR spectra (Figure 4). Budesonide showed peaks at 3499 cm−1, 2956 cm−1, 1722 cm−1, and 1690 cm−1 due to O–H stretching, C–H stretching, and C=O stretching. The characteristic peaks of sodium alginate were observed at 3357 cm−1, 1601 to 1407 cm−1, and 1029 cm−1 due to hydroxyl group, COO− group, symmetric and asymmetric stretching vibrations, and C–O–C group stretching vibrations, respectively. Chitosan spectra showed peaks at 3414 cm−1, 1538 cm−1, 1402 cm−1, and 1101 cm−1 due to presence of N–H stretching of amine group and presence of secondary hydroxyl group. Pluronic F-68 showed functional group peak at 1154.19 cm−1. However, in the final spectrum of formulation, budesonide showed minor shifting of peaks to 3487 cm−1, 2971 cm−1, 1705 cm−1, and 1638 cm−1 for O–H stretching, C–H stretching, and C=O stretching. Minor shifting in the peaks of sodium alginate was observed at 3987 cm−1, 1638 cm−1 to 1562 cm−1, and 963 cm−1 for OH, COO−, and C–O–C groups, respectively. Furthermore, in chitosan, shifting of NH2 group, amide group, and N–H stretching and hydroxyl group was carried out to 3487 cm−1, 1467 cm−1, 1459 cm−1, and 1136 cm−1, respectively. This shifting of functional groups was attributed to the formation of hydrogen bonding and conversion to amorphous form [4, 39].

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus