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Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus

(a) TEM image and (b) SEM image of formulated DPI.
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Related In: Results  -  Collection


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fig3: (a) TEM image and (b) SEM image of formulated DPI.

Mentions: As observed from the TEM depicted in Figure 3(a) the image clearly indicates the presence of drug particles encapsulated in the microparticles of formulated DPI. Observed particles have uniform spherical nature.


Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

(a) TEM image and (b) SEM image of formulated DPI.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590799&req=5

fig3: (a) TEM image and (b) SEM image of formulated DPI.
Mentions: As observed from the TEM depicted in Figure 3(a) the image clearly indicates the presence of drug particles encapsulated in the microparticles of formulated DPI. Observed particles have uniform spherical nature.

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus