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Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus

Zeta potential of formulated DPI.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Zeta potential of formulated DPI.

Mentions: The final formulation has shown −17.5 mV of surface charge (Figure 2). This has resulted from higher concentration of calcium chloride than the chitosan in the final formulation where calcium ions cooperatively bind the alginates molecules preventing chitosan from forming the coat around the alginate molecules. Also it may happen due to inadequate deacylation of chitosan used in the final formulation where stretching of deacetylated chains was not fully carried out due to electrostatic repulsion between the NH3 groups that may yield irregular and nonuniform coating of the chitosan resulting in negative charge of the particles [21, 33, 36, 37]. The charge on the human respiratory tract is negative due to presence of mucin [38]. As per the charge theory, negatively charged particles are more responsible for repulsion in between the particles. Therefore, negative charge on the respiratory tract and formulated DPI was responsible for more prominent repulsive forces and was responsible for increasing the time of flight of the budesonide DPI which leads to increasing the deposition of drug in the larger airway region of the lung.


Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

Mali AJ, Pawar AP, Purohit RN - J Pharm (Cairo) (2014)

Zeta potential of formulated DPI.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590799&req=5

fig2: Zeta potential of formulated DPI.
Mentions: The final formulation has shown −17.5 mV of surface charge (Figure 2). This has resulted from higher concentration of calcium chloride than the chitosan in the final formulation where calcium ions cooperatively bind the alginates molecules preventing chitosan from forming the coat around the alginate molecules. Also it may happen due to inadequate deacylation of chitosan used in the final formulation where stretching of deacetylated chains was not fully carried out due to electrostatic repulsion between the NH3 groups that may yield irregular and nonuniform coating of the chitosan resulting in negative charge of the particles [21, 33, 36, 37]. The charge on the human respiratory tract is negative due to presence of mucin [38]. As per the charge theory, negatively charged particles are more responsible for repulsion in between the particles. Therefore, negative charge on the respiratory tract and formulated DPI was responsible for more prominent repulsive forces and was responsible for increasing the time of flight of the budesonide DPI which leads to increasing the deposition of drug in the larger airway region of the lung.

Bottom Line: At same time, serious systemic side effects of drugs have become a cause for concern.The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs.This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

ABSTRACT
The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

No MeSH data available.


Related in: MedlinePlus