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Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics.

Sharma D, Singh M, Kumar D, Singh G - J Pharm (Cairo) (2014)

Bottom Line: Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits.Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study.It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur-146001, Punjab, India.

ABSTRACT
Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

No MeSH data available.


Related in: MedlinePlus

FTIR Spectra of Cetirizine Hydrochloride (Pure Drug) V/S FTIR Spectra of Cetirizine Hydrochloride FDT.
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Related In: Results  -  Collection


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fig2: FTIR Spectra of Cetirizine Hydrochloride (Pure Drug) V/S FTIR Spectra of Cetirizine Hydrochloride FDT.

Mentions: The results obtained with IR studies showed that there was no interaction between the drug and other excipients used in the formulation. The FTIR of Cetirizine Hydrochloride had shown intense band at 757.13 cm−1, 1317.62 cm−1, 1055.66 cm−1 and 1184.57 cm−1 corresponding to the presence of functional groups such as aliphatic chlorocompound, carboxylic acid, alkyl substituted ether and tertiary amine. The FTIR of Cetirizine Hydrochloride FDT formulation shown intense bands at 758.41 cm−1, 1312.37 cm−1, 1078.32 cm−1 and 1181.48 cm−1 indicates no change in the functional groups such as aliphatic chlorocompound, carboxylic acid, alkyl substituted ether, and tertiary amine confirming undisturbed structure of Cetirizine Hydrochloride, which indicates no drug-excipient interaction as shown in Figure 2.


Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics.

Sharma D, Singh M, Kumar D, Singh G - J Pharm (Cairo) (2014)

FTIR Spectra of Cetirizine Hydrochloride (Pure Drug) V/S FTIR Spectra of Cetirizine Hydrochloride FDT.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590798&req=5

fig2: FTIR Spectra of Cetirizine Hydrochloride (Pure Drug) V/S FTIR Spectra of Cetirizine Hydrochloride FDT.
Mentions: The results obtained with IR studies showed that there was no interaction between the drug and other excipients used in the formulation. The FTIR of Cetirizine Hydrochloride had shown intense band at 757.13 cm−1, 1317.62 cm−1, 1055.66 cm−1 and 1184.57 cm−1 corresponding to the presence of functional groups such as aliphatic chlorocompound, carboxylic acid, alkyl substituted ether and tertiary amine. The FTIR of Cetirizine Hydrochloride FDT formulation shown intense bands at 758.41 cm−1, 1312.37 cm−1, 1078.32 cm−1 and 1181.48 cm−1 indicates no change in the functional groups such as aliphatic chlorocompound, carboxylic acid, alkyl substituted ether, and tertiary amine confirming undisturbed structure of Cetirizine Hydrochloride, which indicates no drug-excipient interaction as shown in Figure 2.

Bottom Line: Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits.Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study.It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur-146001, Punjab, India.

ABSTRACT
Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

No MeSH data available.


Related in: MedlinePlus