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Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics.

Sharma D, Singh M, Kumar D, Singh G - J Pharm (Cairo) (2014)

Bottom Line: Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits.Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study.It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur-146001, Punjab, India.

ABSTRACT
Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

No MeSH data available.


Related in: MedlinePlus

In-vitro Dissolution Profile of Cetirizine Hydrochloride FDT.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: In-vitro Dissolution Profile of Cetirizine Hydrochloride FDT.

Mentions: In vitro dissolution studies showed that more than 50% of the drug was released from the formulation within 5 minutes. The rapid drug dissolution might be due to easy breakdown of particle by superdisintegrant action. From in vitro dissolution data, it was observed that 94.74 ± 2.48% of Cetirizine Hydrochloride released in 16 minutes as shown in Figure 1 indicates that the tablet complies as per IP specifications, that is, 85%–110%.


Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics.

Sharma D, Singh M, Kumar D, Singh G - J Pharm (Cairo) (2014)

In-vitro Dissolution Profile of Cetirizine Hydrochloride FDT.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590798&req=5

fig1: In-vitro Dissolution Profile of Cetirizine Hydrochloride FDT.
Mentions: In vitro dissolution studies showed that more than 50% of the drug was released from the formulation within 5 minutes. The rapid drug dissolution might be due to easy breakdown of particle by superdisintegrant action. From in vitro dissolution data, it was observed that 94.74 ± 2.48% of Cetirizine Hydrochloride released in 16 minutes as shown in Figure 1 indicates that the tablet complies as per IP specifications, that is, 85%–110%.

Bottom Line: Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits.Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study.It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur-146001, Punjab, India.

ABSTRACT
Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

No MeSH data available.


Related in: MedlinePlus