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Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique.

Kapure VJ, Pande VV, Deshmukh PK - J Pharm (Cairo) (2013)

Bottom Line: In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT).Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication.As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India.

ABSTRACT
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

No MeSH data available.


Related in: MedlinePlus

Dissolution profile of RVT liquisolid compacts and direct compressed tablet in 1.2 pH.
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Related In: Results  -  Collection


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fig5: Dissolution profile of RVT liquisolid compacts and direct compressed tablet in 1.2 pH.

Mentions: Figures 5 and 6 showed the dissolution profile of liquisolid compact of LS-1 to LS-9 with direct compressible tablet in 1.2 pH and distilled water. Liquisolid compact LS-1 produced a higher dissolution in 1.2 pH and distilled water in comparison with conventional tablet.


Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique.

Kapure VJ, Pande VV, Deshmukh PK - J Pharm (Cairo) (2013)

Dissolution profile of RVT liquisolid compacts and direct compressed tablet in 1.2 pH.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590788&req=5

fig5: Dissolution profile of RVT liquisolid compacts and direct compressed tablet in 1.2 pH.
Mentions: Figures 5 and 6 showed the dissolution profile of liquisolid compact of LS-1 to LS-9 with direct compressible tablet in 1.2 pH and distilled water. Liquisolid compact LS-1 produced a higher dissolution in 1.2 pH and distilled water in comparison with conventional tablet.

Bottom Line: In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT).Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication.As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India.

ABSTRACT
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

No MeSH data available.


Related in: MedlinePlus