Limits...
Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique.

Kapure VJ, Pande VV, Deshmukh PK - J Pharm (Cairo) (2013)

Bottom Line: The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions.In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders.As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India.

ABSTRACT
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

No MeSH data available.


Related in: MedlinePlus

DSC thermograms of (a) pure RVT and (b) liquisolid system LS-1.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4590788&req=5

fig3: DSC thermograms of (a) pure RVT and (b) liquisolid system LS-1.

Mentions: The possible interaction between a drug entity and excipient in liquisolid compact was determined by DSC. Figure 3 shows thermal behaviour of the pure component (a) together with the thermal behaviour of the formulated liquisolid system (b). Pure RVT shows two characteristic peaks at 80°C and 164°C this is because of the polymorphic form of RVT, that is, form “S”, and it is a primary indication for crystalline nature of pure drug. Furthermore, thermal behaviour of liquisolid system (LS-1) shows the shifting of peak at 143°C. It indicates that crystalline nature of drug gets completely converted into amorphous form due to which there is a significant change in endothermic peak of formed liquisolid system.


Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique.

Kapure VJ, Pande VV, Deshmukh PK - J Pharm (Cairo) (2013)

DSC thermograms of (a) pure RVT and (b) liquisolid system LS-1.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590788&req=5

fig3: DSC thermograms of (a) pure RVT and (b) liquisolid system LS-1.
Mentions: The possible interaction between a drug entity and excipient in liquisolid compact was determined by DSC. Figure 3 shows thermal behaviour of the pure component (a) together with the thermal behaviour of the formulated liquisolid system (b). Pure RVT shows two characteristic peaks at 80°C and 164°C this is because of the polymorphic form of RVT, that is, form “S”, and it is a primary indication for crystalline nature of pure drug. Furthermore, thermal behaviour of liquisolid system (LS-1) shows the shifting of peak at 143°C. It indicates that crystalline nature of drug gets completely converted into amorphous form due to which there is a significant change in endothermic peak of formed liquisolid system.

Bottom Line: The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions.In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders.As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India.

ABSTRACT
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

No MeSH data available.


Related in: MedlinePlus