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Pentoxifylline Loaded Floating Microballoons: Design, Development and Characterization.

Malik P, Nagaich U, Malik RK, Gulati N - J Pharm (Cairo) (2013)

Bottom Line: The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0 ± 2.87 µm, 80.89 ± 2.24%, 77.85 ± 0.61%, 77.52 ± 2.04%, and 82.21 ± 1.29%, respectively.The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion.The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut 250 103, India.

ABSTRACT
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach. The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time. Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation technique using different concentrations of polymers like HPMC K4M and ethyl cellulose (EC) in ethyl alcohol and dichloromethane organic solvent system. Microballoons were characterized for their particle size, surface morphology, production yield, loading efficiency, buoyancy percentage, and in vitro drug release studies. From the characterization it was observed that increases in amount of polymers (HPMC K4M and EC) led to increased particle size, loading efficiency, and buoyancy percentage, and retarded drug release. The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0 ± 2.87 µm, 80.89 ± 2.24%, 77.85 ± 0.61%, 77.52 ± 2.04%, and 82.21 ± 1.29%, respectively. The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion. The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.

No MeSH data available.


Release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose.
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Related In: Results  -  Collection


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fig3: Release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose.

Mentions: The in vitro drug release of formulations F1, F2, F3, F4, F5, and F6 was found to be 96.81 ± 0.16, 88.84 ± 0.46, 82.21 ± 1.29, 93.13 ± 1.48, 90.16 ± 0.98, and 87.09 ± 1.73 in 12 h, respectively. Results indicate that proportion of polymers in formulation was the key factor governing the release of drug from microballoons. As the concentration of polymer increased, there was an increase in diffusional path length. This may decrease the overall drug release from the polymer matrix. Formulations comprised of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of HPMC K4M in higher proportion [16]. The release profile of pentoxifylline from microballoons for all formulations was shown in Figure 2. The release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose and HPMC K4M was shown in Figures 3 and 4, respectively.


Pentoxifylline Loaded Floating Microballoons: Design, Development and Characterization.

Malik P, Nagaich U, Malik RK, Gulati N - J Pharm (Cairo) (2013)

Release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590787&req=5

fig3: Release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose.
Mentions: The in vitro drug release of formulations F1, F2, F3, F4, F5, and F6 was found to be 96.81 ± 0.16, 88.84 ± 0.46, 82.21 ± 1.29, 93.13 ± 1.48, 90.16 ± 0.98, and 87.09 ± 1.73 in 12 h, respectively. Results indicate that proportion of polymers in formulation was the key factor governing the release of drug from microballoons. As the concentration of polymer increased, there was an increase in diffusional path length. This may decrease the overall drug release from the polymer matrix. Formulations comprised of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of HPMC K4M in higher proportion [16]. The release profile of pentoxifylline from microballoons for all formulations was shown in Figure 2. The release profile of pentoxifylline from microballoons containing varying concentrations of ethyl cellulose and HPMC K4M was shown in Figures 3 and 4, respectively.

Bottom Line: The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0 ± 2.87 µm, 80.89 ± 2.24%, 77.85 ± 0.61%, 77.52 ± 2.04%, and 82.21 ± 1.29%, respectively.The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion.The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut 250 103, India.

ABSTRACT
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach. The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time. Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation technique using different concentrations of polymers like HPMC K4M and ethyl cellulose (EC) in ethyl alcohol and dichloromethane organic solvent system. Microballoons were characterized for their particle size, surface morphology, production yield, loading efficiency, buoyancy percentage, and in vitro drug release studies. From the characterization it was observed that increases in amount of polymers (HPMC K4M and EC) led to increased particle size, loading efficiency, and buoyancy percentage, and retarded drug release. The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0 ± 2.87 µm, 80.89 ± 2.24%, 77.85 ± 0.61%, 77.52 ± 2.04%, and 82.21 ± 1.29%, respectively. The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion. The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.

No MeSH data available.