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Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus

Yearly chemical biomarker–related publications stratified by chemical group and analysis category. Abbreviations: E, exposure assessment; H, health association. Darker colors reflect a higher number of publications for the specified chemical group in a particular year. The scale indicates the publication count by color.
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f4: Yearly chemical biomarker–related publications stratified by chemical group and analysis category. Abbreviations: E, exposure assessment; H, health association. Darker colors reflect a higher number of publications for the specified chemical group in a particular year. The scale indicates the publication count by color.

Mentions: Trends by group and category. The number of yearly chemical biomarker–related publications, after stratification by chemical group and analysis category, are shown in Figure 4. Between 1999 and 2003, publications focused almost exclusively on metals/metalloids (28 of 31); the strong focus on this group continued across all 15 years of the review period. A lack of publications related to other chemical groups prior to 2004 mirrors the public release dates of the NERs; although data on metals and select VOCs, pesticides, and phthalates were available in 1999 (from NHANES III), data on additional chemicals were not available until later years (CDC 2003, 2005, 2009). Indeed, Figure 4 illustrates that initial studies involving PAHs were published in 2004, and those involving PFCs, dioxins/furans/PCBs, environmental phenols, and BFRs were published between 2006 and 2008.


Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Yearly chemical biomarker–related publications stratified by chemical group and analysis category. Abbreviations: E, exposure assessment; H, health association. Darker colors reflect a higher number of publications for the specified chemical group in a particular year. The scale indicates the publication count by color.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590763&req=5

f4: Yearly chemical biomarker–related publications stratified by chemical group and analysis category. Abbreviations: E, exposure assessment; H, health association. Darker colors reflect a higher number of publications for the specified chemical group in a particular year. The scale indicates the publication count by color.
Mentions: Trends by group and category. The number of yearly chemical biomarker–related publications, after stratification by chemical group and analysis category, are shown in Figure 4. Between 1999 and 2003, publications focused almost exclusively on metals/metalloids (28 of 31); the strong focus on this group continued across all 15 years of the review period. A lack of publications related to other chemical groups prior to 2004 mirrors the public release dates of the NERs; although data on metals and select VOCs, pesticides, and phthalates were available in 1999 (from NHANES III), data on additional chemicals were not available until later years (CDC 2003, 2005, 2009). Indeed, Figure 4 illustrates that initial studies involving PAHs were published in 2004, and those involving PFCs, dioxins/furans/PCBs, environmental phenols, and BFRs were published between 2006 and 2008.

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus