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Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus

Chemical groups studied using NHANES biomarker data.
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f2: Chemical groups studied using NHANES biomarker data.

Mentions: Chemical groups. Each publication identified through manual curation was assigned to 1 of 11 groups based on the chemical biomarkers that were studied (Figure 2). Metals/metalloids were by far the most commonly studied group. Studies of metals/metalloids (particularly lead, cadmium, mercury, and arsenic) comprised nearly half (49%) of the chemical biomarker–related publications. The second most studied chemical group was pesticides (9%), which included OP, OC, and pyrethroid insecticides, as well as herbicides, fungicides, and halogenated phenolic compounds. Environmental phenols (including bisphenol A, triclosan, and parabens) were the third most studied group (7%), followed by phthalates (5%), PFCs (5%), PAHs (4%), dioxins/furans/PCBs (4%), VOCs (3%), and BFRs (2%). Multi-group studies comprised 8% of the chemical biomarker–related publications. The remaining 4% of studies focused on a group defined as “other” chemicals; 7 of the 10 publications in this group focused on perchlorate.


Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Chemical groups studied using NHANES biomarker data.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590763&req=5

f2: Chemical groups studied using NHANES biomarker data.
Mentions: Chemical groups. Each publication identified through manual curation was assigned to 1 of 11 groups based on the chemical biomarkers that were studied (Figure 2). Metals/metalloids were by far the most commonly studied group. Studies of metals/metalloids (particularly lead, cadmium, mercury, and arsenic) comprised nearly half (49%) of the chemical biomarker–related publications. The second most studied chemical group was pesticides (9%), which included OP, OC, and pyrethroid insecticides, as well as herbicides, fungicides, and halogenated phenolic compounds. Environmental phenols (including bisphenol A, triclosan, and parabens) were the third most studied group (7%), followed by phthalates (5%), PFCs (5%), PAHs (4%), dioxins/furans/PCBs (4%), VOCs (3%), and BFRs (2%). Multi-group studies comprised 8% of the chemical biomarker–related publications. The remaining 4% of studies focused on a group defined as “other” chemicals; 7 of the 10 publications in this group focused on perchlorate.

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus