Limits...
Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus

Yearly publications (1999–2013) related to the U.S. NHANES, biomarkers, and biomarkers of environmental chemicals. For PubMed search and selection methods, see Supplemental Material, Table S1.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4590763&req=5

f1: Yearly publications (1999–2013) related to the U.S. NHANES, biomarkers, and biomarkers of environmental chemicals. For PubMed search and selection methods, see Supplemental Material, Table S1.

Mentions: Yearly publications. Sixty-eight publications from 1999 were identified that contained keywords related to “NHANES” and “United States” (Figure 1). More than 400 publications were identified from 2013 using the same search criteria. These results of sampled publications reflect a 6-fold increase over a 15-year span, and a median yearly increase of 13%. Considerably fewer publications were identified after adding additional keywords related to “biomarkers.” Only 27 publications from 1999 were identified that contained keywords related to “NHANES,” “United States,” and “biomarkers.” Close to 200 publications from 2013 were identified using the same keywords, indicating an approximate 7-fold increase over the 1999 baseline. Interestingly, the yearly ratios of biomarker-related publications (step two results) to total NHANES-related publications (step one results) were fairly consistent, ranging from 0.36 to 0.47, with a median value of 0.43. Results from a simple regression analysis showed no significant linear trend (p = 0.7) in this ratio, suggesting that the proportional use of NHANES biomarker data (not specific to chemical biomarkers) has been stable over the period of time examined in this study.


Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.

Sobus JR, DeWoskin RS, Tan YM, Pleil JD, Phillips MB, George BJ, Christensen K, Schreinemachers DM, Williams MA, Hubal EA, Edwards SW - Environ. Health Perspect. (2015)

Yearly publications (1999–2013) related to the U.S. NHANES, biomarkers, and biomarkers of environmental chemicals. For PubMed search and selection methods, see Supplemental Material, Table S1.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590763&req=5

f1: Yearly publications (1999–2013) related to the U.S. NHANES, biomarkers, and biomarkers of environmental chemicals. For PubMed search and selection methods, see Supplemental Material, Table S1.
Mentions: Yearly publications. Sixty-eight publications from 1999 were identified that contained keywords related to “NHANES” and “United States” (Figure 1). More than 400 publications were identified from 2013 using the same search criteria. These results of sampled publications reflect a 6-fold increase over a 15-year span, and a median yearly increase of 13%. Considerably fewer publications were identified after adding additional keywords related to “biomarkers.” Only 27 publications from 1999 were identified that contained keywords related to “NHANES,” “United States,” and “biomarkers.” Close to 200 publications from 2013 were identified using the same keywords, indicating an approximate 7-fold increase over the 1999 baseline. Interestingly, the yearly ratios of biomarker-related publications (step two results) to total NHANES-related publications (step one results) were fairly consistent, ranging from 0.36 to 0.47, with a median value of 0.43. Results from a simple regression analysis showed no significant linear trend (p = 0.7) in this ratio, suggesting that the proportional use of NHANES biomarker data (not specific to chemical biomarkers) has been stable over the period of time examined in this study.

Bottom Line: Publications linking chemical biomarkers to health metrics have increased dramatically in recent years.New studies are addressing challenges related to NHANES data interpretation in health risk contexts.Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

View Article: PubMed Central - PubMed

Affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA.

ABSTRACT

Background: Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments.

Objectives: This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments.

Methods: A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends.

Results: A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts.

Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized.

No MeSH data available.


Related in: MedlinePlus