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Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach.

Agay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basagaña X, Robinson O, Casas M, Sunyer J, Vrijheid M - Environ. Health Perspect. (2015)

Bottom Line: Exposure in the second tertile of the phthalate factor was inversely associated with overweight.Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population.Other EDCs exposures did not confound this association.

View Article: PubMed Central - PubMed

Affiliation: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

ABSTRACT

Background: Prenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied.

Objective: We evaluated the associations between pre- and perinatal biomarker concentrations of 27 EDCs and child weight status at 7 years of age.

Methods: In pregnant women enrolled in a Spanish birth cohort study between 2004 and 2006, we measured the concentrations of 10 phthalate metabolites, bisphenol A, cadmium, arsenic, and lead in two maternal pregnancy urine samples; 6 organochlorine compounds in maternal pregnancy serum; mercury in cord blood; and 6 polybrominated diphenyl ether congeners in colostrum. Among 470 children at 7 years, body mass index (BMI) z-scores were calculated, and overweight was defined as BMI > 85th percentile. We estimated associations with EDCs in single-pollutant models and applied principal-component analysis (PCA) on the 27 pollutant concentrations.

Results: In single-pollutant models, HCB (hexachlorobenzene), βHCH (β-hexachlorocyclohexane), and polychlorinated biphenyl (PCB) congeners 138 and 180 were associated with increased child BMI z-scores; and HCB, βHCH, PCB-138, and DDE (dichlorodiphenyldichloroethylene) with overweight risk. PCA generated four factors that accounted for 43.4% of the total variance. The organochlorine factor was positively associated with BMI z-scores and with overweight (adjusted RR, tertile 3 vs. 1: 2.59; 95% CI: 1.19, 5.63), and these associations were robust to adjustment for other EDCs. Exposure in the second tertile of the phthalate factor was inversely associated with overweight.

Conclusions: Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association.

No MeSH data available.


Related in: MedlinePlus

Crude and adjusted associations [β coefficient (95% CI)] between maternal exposure to tertiles of 27 EDCs and child zBMI at age 7 years, single- pollutant models, for complete case and imputed data (n = 470). Abbreviations: As, arsenic; BDE, polybrominated diphenyl ethers congeners; βHCH, β-hexachlorocyclohexane; BPA, bisphenol A; Cd, cadmium; CI, confidence interval; DDE, dichlorodiphenyldichloroethylene; EDCs, endocrine-disrupting chemicals; HCB, hexachlorobenzene; Hg, Mercury; MBzP, monobenzyl phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate; MiBP, monoisobutyl phthalate; MnBP, mono-n-butyl phthalate; Pb, lead; MCMHP, mono(2-carboxyhexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; 7OHMMeOP, mono(4-methyl-7-hydroxyoctyl) phthalate; PCBs, polychlorinated biphenyl congeners; zBMI, body mass index z-score.
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f1: Crude and adjusted associations [β coefficient (95% CI)] between maternal exposure to tertiles of 27 EDCs and child zBMI at age 7 years, single- pollutant models, for complete case and imputed data (n = 470). Abbreviations: As, arsenic; BDE, polybrominated diphenyl ethers congeners; βHCH, β-hexachlorocyclohexane; BPA, bisphenol A; Cd, cadmium; CI, confidence interval; DDE, dichlorodiphenyldichloroethylene; EDCs, endocrine-disrupting chemicals; HCB, hexachlorobenzene; Hg, Mercury; MBzP, monobenzyl phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate; MiBP, monoisobutyl phthalate; MnBP, mono-n-butyl phthalate; Pb, lead; MCMHP, mono(2-carboxyhexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; 7OHMMeOP, mono(4-methyl-7-hydroxyoctyl) phthalate; PCBs, polychlorinated biphenyl congeners; zBMI, body mass index z-score.

Mentions: Single-pollutant, complete-case, adjusted models for the 27 EDCs exposures showed a statistically significant increase in zBMI with increasing exposure to HCB [adjusted (adj) β tertile 3 vs. 1: 0.49; 95% CI: 0.16, 0.82], βHCH (adj β tertile 3 vs. 1: 0.37; 95% CI: 0.08, 0.82), PCB-138 (adj β tertile 3 vs. 1: 0.36; 95% CI: 0.04, 0.68), and PCB-180 (adj β tertile 3 vs. 1: 0.41; 95% CI: 0.05, 0.77) (Figure 1; see also Supplemental Material, Table S1). For DDE, tertile 3 estimates were increased compared with tertile 1 and nearly reached statistical significance (adj β tertile 3 vs. 1: 0.27; 95% CI: –0.02, 0.56). For 7OHMMeOP [mono(4-methyl-7-hydroxyoctyl) phthalate], tertile 3 estimates were decreased compared to tertile 1 and nearly reached statistical significance (adj β tertile 3 vs. 1: –0.29; 95% CI: –0.59, 0.01). Certain phthalates and certain PBDEs showed nonsignificant negative associations. For example, for PBDE-53 and PBDE-54 tertile 2 estimates were decreased compared with tertile 1 (adj β tertile 2 vs. 1: –0.31; 95% CI: –0.73, 0.11) (Figure 1; see also Supplemental Material, Table S1).


Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach.

Agay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basagaña X, Robinson O, Casas M, Sunyer J, Vrijheid M - Environ. Health Perspect. (2015)

Crude and adjusted associations [β coefficient (95% CI)] between maternal exposure to tertiles of 27 EDCs and child zBMI at age 7 years, single- pollutant models, for complete case and imputed data (n = 470). Abbreviations: As, arsenic; BDE, polybrominated diphenyl ethers congeners; βHCH, β-hexachlorocyclohexane; BPA, bisphenol A; Cd, cadmium; CI, confidence interval; DDE, dichlorodiphenyldichloroethylene; EDCs, endocrine-disrupting chemicals; HCB, hexachlorobenzene; Hg, Mercury; MBzP, monobenzyl phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate; MiBP, monoisobutyl phthalate; MnBP, mono-n-butyl phthalate; Pb, lead; MCMHP, mono(2-carboxyhexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; 7OHMMeOP, mono(4-methyl-7-hydroxyoctyl) phthalate; PCBs, polychlorinated biphenyl congeners; zBMI, body mass index z-score.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590760&req=5

f1: Crude and adjusted associations [β coefficient (95% CI)] between maternal exposure to tertiles of 27 EDCs and child zBMI at age 7 years, single- pollutant models, for complete case and imputed data (n = 470). Abbreviations: As, arsenic; BDE, polybrominated diphenyl ethers congeners; βHCH, β-hexachlorocyclohexane; BPA, bisphenol A; Cd, cadmium; CI, confidence interval; DDE, dichlorodiphenyldichloroethylene; EDCs, endocrine-disrupting chemicals; HCB, hexachlorobenzene; Hg, Mercury; MBzP, monobenzyl phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate; MiBP, monoisobutyl phthalate; MnBP, mono-n-butyl phthalate; Pb, lead; MCMHP, mono(2-carboxyhexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; 7OHMMeOP, mono(4-methyl-7-hydroxyoctyl) phthalate; PCBs, polychlorinated biphenyl congeners; zBMI, body mass index z-score.
Mentions: Single-pollutant, complete-case, adjusted models for the 27 EDCs exposures showed a statistically significant increase in zBMI with increasing exposure to HCB [adjusted (adj) β tertile 3 vs. 1: 0.49; 95% CI: 0.16, 0.82], βHCH (adj β tertile 3 vs. 1: 0.37; 95% CI: 0.08, 0.82), PCB-138 (adj β tertile 3 vs. 1: 0.36; 95% CI: 0.04, 0.68), and PCB-180 (adj β tertile 3 vs. 1: 0.41; 95% CI: 0.05, 0.77) (Figure 1; see also Supplemental Material, Table S1). For DDE, tertile 3 estimates were increased compared with tertile 1 and nearly reached statistical significance (adj β tertile 3 vs. 1: 0.27; 95% CI: –0.02, 0.56). For 7OHMMeOP [mono(4-methyl-7-hydroxyoctyl) phthalate], tertile 3 estimates were decreased compared to tertile 1 and nearly reached statistical significance (adj β tertile 3 vs. 1: –0.29; 95% CI: –0.59, 0.01). Certain phthalates and certain PBDEs showed nonsignificant negative associations. For example, for PBDE-53 and PBDE-54 tertile 2 estimates were decreased compared with tertile 1 (adj β tertile 2 vs. 1: –0.31; 95% CI: –0.73, 0.11) (Figure 1; see also Supplemental Material, Table S1).

Bottom Line: Exposure in the second tertile of the phthalate factor was inversely associated with overweight.Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population.Other EDCs exposures did not confound this association.

View Article: PubMed Central - PubMed

Affiliation: Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

ABSTRACT

Background: Prenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied.

Objective: We evaluated the associations between pre- and perinatal biomarker concentrations of 27 EDCs and child weight status at 7 years of age.

Methods: In pregnant women enrolled in a Spanish birth cohort study between 2004 and 2006, we measured the concentrations of 10 phthalate metabolites, bisphenol A, cadmium, arsenic, and lead in two maternal pregnancy urine samples; 6 organochlorine compounds in maternal pregnancy serum; mercury in cord blood; and 6 polybrominated diphenyl ether congeners in colostrum. Among 470 children at 7 years, body mass index (BMI) z-scores were calculated, and overweight was defined as BMI > 85th percentile. We estimated associations with EDCs in single-pollutant models and applied principal-component analysis (PCA) on the 27 pollutant concentrations.

Results: In single-pollutant models, HCB (hexachlorobenzene), βHCH (β-hexachlorocyclohexane), and polychlorinated biphenyl (PCB) congeners 138 and 180 were associated with increased child BMI z-scores; and HCB, βHCH, PCB-138, and DDE (dichlorodiphenyldichloroethylene) with overweight risk. PCA generated four factors that accounted for 43.4% of the total variance. The organochlorine factor was positively associated with BMI z-scores and with overweight (adjusted RR, tertile 3 vs. 1: 2.59; 95% CI: 1.19, 5.63), and these associations were robust to adjustment for other EDCs. Exposure in the second tertile of the phthalate factor was inversely associated with overweight.

Conclusions: Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association.

No MeSH data available.


Related in: MedlinePlus