Limits...
Obesogen Holdover: Prenatal Exposure Predicts Cardiometabolic Risk Factors in Childhood.

Konkel L - Environ. Health Perspect. (2015)

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In this issue of EHP, researchers examine the link between prenatal exposure to three kinds of POPs and cardiometabolic risk factors in young children... Studies in adults have linked exposures to certain POPs with cardiometabolic risk factors including high blood pressure and high blood lipids, but evidence in children is scarce... The researchers measured concentrations of dichlorodiphenyldichloroethene (DDE), hexachlorobenzene (HCB), and polychlorinated biphenyls (PCBs) in blood samples taken from the mothers around the third or fourth month of pregnancy... Other cardiometabolic risk factors measured included blood pressure and blood lipid levels... The researchers controlled for confounding factors including maternal age at delivery, mother’s pre-pregnancy body mass index (BMI) and weight gain during pregnancy, and breastfeeding duration... A 10-fold increase in the mothers’ HCB concentrations was associated with higher risks of generalized and abdominal obesity in the children, greater skinfold thickness, higher systolic blood pressure, and a modest increase in child BMI z-score. (BMI z-scores are used to report obesity in children because they account for the child’s sex and exact age at assessment, in contrast to BMI, which accounts only for height and weight.) Prenatal DDE exposure was associated with higher BMI z-score, increased risk of abdominal obesity, and higher diastolic blood pressure... PCBs were not associated with any of the risk factors assessed... Chan School of Public Health... That’s because animal data and previous studies on childhood BMI  reported effect modification by sex, which Valvi says is worth exploring further in larger populations... Valvi was not involved with the current study. “The results are pretty consistent for HCB and DDE across several measurements of adiposity, which strengthens confidence that the associations are real,” says Michele La Merrill, a toxicologist at the University of California, Davis... The authors maintain that as Greece, the United States, and other countries around the world deal with an increasing prevalence of childhood obesity, the findings are important from a public health perspective... Knowledge of environmental risk factors could help to reverse the trend, according to Vafeiadi. “It’s important to monitor risk factors and develop interventions in a young population before [unhealthy] lifestyle choices have been established,” she says... Vafeiadi and colleagues hope next to study exposures to nonpersistent chemicals (such as bisphenol A) and combinations of suspected obesogens in relation to cardiometabolic risk factors in the Rhea cohort.

No MeSH data available.


Related in: MedlinePlus

Exposure to POPs can begin long before birth, and the health effects may last a lifetime.© IvanJekic/iStockphoto
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4590737&req=5

d35e113: Exposure to POPs can begin long before birth, and the health effects may last a lifetime.© IvanJekic/iStockphoto


Obesogen Holdover: Prenatal Exposure Predicts Cardiometabolic Risk Factors in Childhood.

Konkel L - Environ. Health Perspect. (2015)

Exposure to POPs can begin long before birth, and the health effects may last a lifetime.© IvanJekic/iStockphoto
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590737&req=5

d35e113: Exposure to POPs can begin long before birth, and the health effects may last a lifetime.© IvanJekic/iStockphoto

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In this issue of EHP, researchers examine the link between prenatal exposure to three kinds of POPs and cardiometabolic risk factors in young children... Studies in adults have linked exposures to certain POPs with cardiometabolic risk factors including high blood pressure and high blood lipids, but evidence in children is scarce... The researchers measured concentrations of dichlorodiphenyldichloroethene (DDE), hexachlorobenzene (HCB), and polychlorinated biphenyls (PCBs) in blood samples taken from the mothers around the third or fourth month of pregnancy... Other cardiometabolic risk factors measured included blood pressure and blood lipid levels... The researchers controlled for confounding factors including maternal age at delivery, mother’s pre-pregnancy body mass index (BMI) and weight gain during pregnancy, and breastfeeding duration... A 10-fold increase in the mothers’ HCB concentrations was associated with higher risks of generalized and abdominal obesity in the children, greater skinfold thickness, higher systolic blood pressure, and a modest increase in child BMI z-score. (BMI z-scores are used to report obesity in children because they account for the child’s sex and exact age at assessment, in contrast to BMI, which accounts only for height and weight.) Prenatal DDE exposure was associated with higher BMI z-score, increased risk of abdominal obesity, and higher diastolic blood pressure... PCBs were not associated with any of the risk factors assessed... Chan School of Public Health... That’s because animal data and previous studies on childhood BMI  reported effect modification by sex, which Valvi says is worth exploring further in larger populations... Valvi was not involved with the current study. “The results are pretty consistent for HCB and DDE across several measurements of adiposity, which strengthens confidence that the associations are real,” says Michele La Merrill, a toxicologist at the University of California, Davis... The authors maintain that as Greece, the United States, and other countries around the world deal with an increasing prevalence of childhood obesity, the findings are important from a public health perspective... Knowledge of environmental risk factors could help to reverse the trend, according to Vafeiadi. “It’s important to monitor risk factors and develop interventions in a young population before [unhealthy] lifestyle choices have been established,” she says... Vafeiadi and colleagues hope next to study exposures to nonpersistent chemicals (such as bisphenol A) and combinations of suspected obesogens in relation to cardiometabolic risk factors in the Rhea cohort.

No MeSH data available.


Related in: MedlinePlus