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A One-Two Punch to Bone: Assessing the Combined Impact of Lead and a High-Fat Diet.

Barrett JR - Environ. Health Perspect. (2015)

View Article: PubMed Central - PubMed

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Lead exposure and obesity each adversely affect bone formation and maintenance, which can potentially lead to low bone mass and an increased risk of fracture... These experiments investigated the effects of these exposures on the transcription of genes that code components relevant to the Wnt signaling pathway... At 4–8 μg/dL, the blood lead levels in the treated mice were comparable to those that occur in children in the 97.5th percentile of lead exposure... The authors also found that lead exposure and a high-fat diet were each associated with reduced bone quality in mice, which was amplified when both factors were present; however, only lead exposure was associated with statistically significant changes in bone strength... Biomarker measurements from blood and MSCs showed a shift toward bone resorption and adipocyte formation at the expense of osteoblast formation for both lead exposure and a high-fat diet... These findings suggest that the normal balance of formation and resorption in bone was tipped toward the latter and, consequently, loss of bone mass... In addition, the mice on a high-fat diet developed obesity and other symptoms of metabolic dysregulation... The in vitro experiments with osteoblast precursor cells indicated that both lead and fatty acids altered factors that influence Wnt signaling... This provides a potential mechanism by which obesity and lead undermine the appropriate differentiation of stem cells. “It’s an interesting study that reports an association,” says Bart Williams, director of the Center for Cancer and Cell Biology at Van Andel Research Institute in Grand Rapids, Michigan. “They’ve linked the lead exposure and a correlation with a change in some aspects of Wnt signaling... Moving forward, it will be important to really nail down the molecular mechanisms. ” Williams was not involved in the study... A particular strength of this study was that it considered more than one factor that influences bone quality. “However, there are many factors that have to be taken into account when one considers bone quality,” says coauthor Robert Mooney, a professor in the Department of Pathology and Laboratory Medicine at the University of Rochester Medical Center. “Our study was just one example of taking two factors out of the environment, putting them together, and showing that, indeed, the bone quality is poorer due to each of those contributions. ” The actual environment is enormously complex, of course, and a wide range of other factors can have an impact on bone health in humans, among them diet, exercise, and smoking. “It’s important to sort out the factors that might cause poor bone quality,” Mooney says. “Until we know, it impairs our ability to develop therapeutic approaches. ”

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Lead exposure and obesity are both associated with increased risk of osteoporosis in humans. A new study explores potential mechanisms behind these associations.© Henning Dalhoff/Getty Images
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d35e113: Lead exposure and obesity are both associated with increased risk of osteoporosis in humans. A new study explores potential mechanisms behind these associations.© Henning Dalhoff/Getty Images


A One-Two Punch to Bone: Assessing the Combined Impact of Lead and a High-Fat Diet.

Barrett JR - Environ. Health Perspect. (2015)

Lead exposure and obesity are both associated with increased risk of osteoporosis in humans. A new study explores potential mechanisms behind these associations.© Henning Dalhoff/Getty Images
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590736&req=5

d35e113: Lead exposure and obesity are both associated with increased risk of osteoporosis in humans. A new study explores potential mechanisms behind these associations.© Henning Dalhoff/Getty Images

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Lead exposure and obesity each adversely affect bone formation and maintenance, which can potentially lead to low bone mass and an increased risk of fracture... These experiments investigated the effects of these exposures on the transcription of genes that code components relevant to the Wnt signaling pathway... At 4–8 μg/dL, the blood lead levels in the treated mice were comparable to those that occur in children in the 97.5th percentile of lead exposure... The authors also found that lead exposure and a high-fat diet were each associated with reduced bone quality in mice, which was amplified when both factors were present; however, only lead exposure was associated with statistically significant changes in bone strength... Biomarker measurements from blood and MSCs showed a shift toward bone resorption and adipocyte formation at the expense of osteoblast formation for both lead exposure and a high-fat diet... These findings suggest that the normal balance of formation and resorption in bone was tipped toward the latter and, consequently, loss of bone mass... In addition, the mice on a high-fat diet developed obesity and other symptoms of metabolic dysregulation... The in vitro experiments with osteoblast precursor cells indicated that both lead and fatty acids altered factors that influence Wnt signaling... This provides a potential mechanism by which obesity and lead undermine the appropriate differentiation of stem cells. “It’s an interesting study that reports an association,” says Bart Williams, director of the Center for Cancer and Cell Biology at Van Andel Research Institute in Grand Rapids, Michigan. “They’ve linked the lead exposure and a correlation with a change in some aspects of Wnt signaling... Moving forward, it will be important to really nail down the molecular mechanisms. ” Williams was not involved in the study... A particular strength of this study was that it considered more than one factor that influences bone quality. “However, there are many factors that have to be taken into account when one considers bone quality,” says coauthor Robert Mooney, a professor in the Department of Pathology and Laboratory Medicine at the University of Rochester Medical Center. “Our study was just one example of taking two factors out of the environment, putting them together, and showing that, indeed, the bone quality is poorer due to each of those contributions. ” The actual environment is enormously complex, of course, and a wide range of other factors can have an impact on bone health in humans, among them diet, exercise, and smoking. “It’s important to sort out the factors that might cause poor bone quality,” Mooney says. “Until we know, it impairs our ability to develop therapeutic approaches. ”

No MeSH data available.


Related in: MedlinePlus