Limits...
White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.

Tang VM, Lang DJ, Giesbrecht CJ, Panenka WJ, Willi T, Procyshyn RM, Vila-Rodriguez F, Jenkins W, Lecomte T, Boyda HN, Aleksic A, MacEwan GW, Honer WG, Barr AM - BMC Res Notes (2015)

Bottom Line: The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05).This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory.Further study on this medical comorbidity is required.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, V6T2A1, Canada. victormtang@gmail.com.

ABSTRACT

Background: Psychostimulant drug use is commonly associated with drug-related infection, including the human immunodeficiency virus (HIV). Both psychostimulant use and HIV infection are known to damage brain white matter and impair cognition. To date, no study has examined white matter integrity using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) in chronic psychostimulant users with comorbid HIV infection, and determined the relationship of white matter integrity to cognitive function.

Methods: Twenty-one subjects (mean age 37.5 ± 9.0 years) with a history of heavy psychostimulant use and HIV infection (8.7 ± 4.3 years) and 22 matched controls were scanned on a 3T MRI. Fractional anisotropy (FA) values were calculated with DTI software. Four regions of interest were manually segmented, including the genu of the corpus callosum, left and right anterior limbs of the internal capsule, and the anterior commissure. Subjects also completed a neurocognitive battery and questionnaires about physical and mental health.

Results: The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05). This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory. FA values for the white matter tracts correlated with cognitive performance on many of the neurocognitive tests.

Conclusions: White matter integrity was thus impaired in subjects with psychostimulant use and comorbid HIV infection, which predicted worsened cognitive performance on a range of tests. Further study on this medical comorbidity is required.

No MeSH data available.


Related in: MedlinePlus

Regions of interest include white matter pathways in the forebrain that are important in neurocognitive function and known to be damaged by HIV infection or psychostimulant use. Pathways include the a anterior commissure (sagittal view), b left (blue) and right (red) anterior limbs of the internal capsule (axial view) and c corpus callosum genu (axial view)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4590729&req=5

Fig1: Regions of interest include white matter pathways in the forebrain that are important in neurocognitive function and known to be damaged by HIV infection or psychostimulant use. Pathways include the a anterior commissure (sagittal view), b left (blue) and right (red) anterior limbs of the internal capsule (axial view) and c corpus callosum genu (axial view)

Mentions: Summary FA values are shown in Table 6. Significant between-group differences in FA values were seen in the corpus callosum genu (t(40) = 3.84 p < 0.001), left (t(40) = 3.23 p < 0.005) and right (t(40) = 2.30 p < 0.05) anterior limbs of the internal capsule, and in the anterior commissure (t(40) = 2.10 p < 0.05), as FA values were lower for the patient group in all of these white matter pathways (Fig. 1). Correlational analyses did not reveal relationships between FA and age in either group for any ROI. There were also significant group differences for medial diffusivity (MD) and radial diffusivity (RD) values for all pathways other than the anterior commissure, and differences in axial diffusivity (AD) values for both the left and right anterior limb of the internal capsule pathways. Total white matter volume in the patient group was smaller than the control group, but this narrowly failed to obtain significance when co-varied for total brain volume (p = 0.052).Table 6


White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.

Tang VM, Lang DJ, Giesbrecht CJ, Panenka WJ, Willi T, Procyshyn RM, Vila-Rodriguez F, Jenkins W, Lecomte T, Boyda HN, Aleksic A, MacEwan GW, Honer WG, Barr AM - BMC Res Notes (2015)

Regions of interest include white matter pathways in the forebrain that are important in neurocognitive function and known to be damaged by HIV infection or psychostimulant use. Pathways include the a anterior commissure (sagittal view), b left (blue) and right (red) anterior limbs of the internal capsule (axial view) and c corpus callosum genu (axial view)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4590729&req=5

Fig1: Regions of interest include white matter pathways in the forebrain that are important in neurocognitive function and known to be damaged by HIV infection or psychostimulant use. Pathways include the a anterior commissure (sagittal view), b left (blue) and right (red) anterior limbs of the internal capsule (axial view) and c corpus callosum genu (axial view)
Mentions: Summary FA values are shown in Table 6. Significant between-group differences in FA values were seen in the corpus callosum genu (t(40) = 3.84 p < 0.001), left (t(40) = 3.23 p < 0.005) and right (t(40) = 2.30 p < 0.05) anterior limbs of the internal capsule, and in the anterior commissure (t(40) = 2.10 p < 0.05), as FA values were lower for the patient group in all of these white matter pathways (Fig. 1). Correlational analyses did not reveal relationships between FA and age in either group for any ROI. There were also significant group differences for medial diffusivity (MD) and radial diffusivity (RD) values for all pathways other than the anterior commissure, and differences in axial diffusivity (AD) values for both the left and right anterior limb of the internal capsule pathways. Total white matter volume in the patient group was smaller than the control group, but this narrowly failed to obtain significance when co-varied for total brain volume (p = 0.052).Table 6

Bottom Line: The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05).This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory.Further study on this medical comorbidity is required.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, V6T2A1, Canada. victormtang@gmail.com.

ABSTRACT

Background: Psychostimulant drug use is commonly associated with drug-related infection, including the human immunodeficiency virus (HIV). Both psychostimulant use and HIV infection are known to damage brain white matter and impair cognition. To date, no study has examined white matter integrity using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) in chronic psychostimulant users with comorbid HIV infection, and determined the relationship of white matter integrity to cognitive function.

Methods: Twenty-one subjects (mean age 37.5 ± 9.0 years) with a history of heavy psychostimulant use and HIV infection (8.7 ± 4.3 years) and 22 matched controls were scanned on a 3T MRI. Fractional anisotropy (FA) values were calculated with DTI software. Four regions of interest were manually segmented, including the genu of the corpus callosum, left and right anterior limbs of the internal capsule, and the anterior commissure. Subjects also completed a neurocognitive battery and questionnaires about physical and mental health.

Results: The psychostimulant using, HIV positive group displayed decreased white matter integrity, with significantly lower FA values for all white matter tracts (p < 0.05). This group also exhibited decreased cognitive performance on tasks that assessed cognitive set-shifting, fine motor speed and verbal memory. FA values for the white matter tracts correlated with cognitive performance on many of the neurocognitive tests.

Conclusions: White matter integrity was thus impaired in subjects with psychostimulant use and comorbid HIV infection, which predicted worsened cognitive performance on a range of tests. Further study on this medical comorbidity is required.

No MeSH data available.


Related in: MedlinePlus