Limits...
Kidney-targeted drug delivery systems.

Zhou P, Sun X, Zhang Z - Acta Pharm Sin B (2014)

Bottom Line: Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases.We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney.New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

ABSTRACT
Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.

No MeSH data available.


Related in: MedlinePlus

The strategies of kidney-targeted drug delivery systems.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4590725&req=5

f0005: The strategies of kidney-targeted drug delivery systems.

Mentions: To achieve the goal of kidney-targeted drug delivery, prodrugs2 and macromolecular carriers3 have been the most common strategies employed (Fig. 1). Among the macromolecular carriers, proteins, peptides, antibodies and viruses have been utilized. Prodrugs capable of selectively targeting the kidney generally release the active drug through the action of renal enzymes.


Kidney-targeted drug delivery systems.

Zhou P, Sun X, Zhang Z - Acta Pharm Sin B (2014)

The strategies of kidney-targeted drug delivery systems.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590725&req=5

f0005: The strategies of kidney-targeted drug delivery systems.
Mentions: To achieve the goal of kidney-targeted drug delivery, prodrugs2 and macromolecular carriers3 have been the most common strategies employed (Fig. 1). Among the macromolecular carriers, proteins, peptides, antibodies and viruses have been utilized. Prodrugs capable of selectively targeting the kidney generally release the active drug through the action of renal enzymes.

Bottom Line: Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases.We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney.New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

ABSTRACT
Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.

No MeSH data available.


Related in: MedlinePlus