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The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.

Amstrup AK, Sikjaer T, Mosekilde L, Rejnmark L - Nutr J (2015)

Bottom Line: Furthermore, no significant changes between groups were observed in muscle strength in neither upper- nor lower extremities.Treatment did not affect quality of life or sleep.In women with a good quality of sleep, melatonin has no effect, however in poor quality of sleep, small doses of melatonin trended towards improving the quality. (# NCT01690000).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Tage-Hansens Gade 2 DK-Aarhus C, 8000, Aarhus, Denmark. anne_kristine_am@hotmail.com.

ABSTRACT

Background: Melatonin is often used as a sleeping aid in elderly adults. As previous studies suggest a protective role of melatonin against osteoporosis, it is important to document its safety. Treatment should not cause any hangover effect that could potentially lead to falls and fractures. We therefore aimed to evaluate the effect of melatonin on balance- and muscle function.

Methods and patients: In a double-blind placebo-controlled study, we randomized 81 postmenopausal women with osteopenia to receive 1 or 3 mg melatonin, or placebo nightly for 12 months. Postural balance as well as muscle function was measured. In addition, we assessed quality of life and sleep at baseline and after 12 months treatment.

Results: Compared to placebo, one-year treatment with melatonin did not affect postural balance or risk of falls. Furthermore, no significant changes between groups were observed in muscle strength in neither upper- nor lower extremities. Treatment did not affect quality of life or sleep. However, in the subgroup of women with sleep disturbances at baseline, a trend towards an improved sleep quality was seen (p = 0.08).

Conclusion: Treatment with melatonin is safe in postmenopausal women with osteopenia. There is no hangover effect affecting balance- and muscle function following the intake of melatonin. In women with a good quality of sleep, melatonin has no effect, however in poor quality of sleep, small doses of melatonin trended towards improving the quality.

Trial registration: (# NCT01690000).

No MeSH data available.


Related in: MedlinePlus

Effects of treatment with placebo or melatonin on blood pressure and heart rate. Mean ± SD
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Fig1: Effects of treatment with placebo or melatonin on blood pressure and heart rate. Mean ± SD

Mentions: Heart rate and blood pressure did not differ between groups at baseline. Compared with placebo, melatonin caused a non-significantly decrease in systolic (5 mmHg, p = 0.12) and diastolic (2 mmHg, p = 0.40) blood pressure (Fig. 1). Heart rate did not change in response to treatment (data not shown).Fig. 1


The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.

Amstrup AK, Sikjaer T, Mosekilde L, Rejnmark L - Nutr J (2015)

Effects of treatment with placebo or melatonin on blood pressure and heart rate. Mean ± SD
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4590707&req=5

Fig1: Effects of treatment with placebo or melatonin on blood pressure and heart rate. Mean ± SD
Mentions: Heart rate and blood pressure did not differ between groups at baseline. Compared with placebo, melatonin caused a non-significantly decrease in systolic (5 mmHg, p = 0.12) and diastolic (2 mmHg, p = 0.40) blood pressure (Fig. 1). Heart rate did not change in response to treatment (data not shown).Fig. 1

Bottom Line: Furthermore, no significant changes between groups were observed in muscle strength in neither upper- nor lower extremities.Treatment did not affect quality of life or sleep.In women with a good quality of sleep, melatonin has no effect, however in poor quality of sleep, small doses of melatonin trended towards improving the quality. (# NCT01690000).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Tage-Hansens Gade 2 DK-Aarhus C, 8000, Aarhus, Denmark. anne_kristine_am@hotmail.com.

ABSTRACT

Background: Melatonin is often used as a sleeping aid in elderly adults. As previous studies suggest a protective role of melatonin against osteoporosis, it is important to document its safety. Treatment should not cause any hangover effect that could potentially lead to falls and fractures. We therefore aimed to evaluate the effect of melatonin on balance- and muscle function.

Methods and patients: In a double-blind placebo-controlled study, we randomized 81 postmenopausal women with osteopenia to receive 1 or 3 mg melatonin, or placebo nightly for 12 months. Postural balance as well as muscle function was measured. In addition, we assessed quality of life and sleep at baseline and after 12 months treatment.

Results: Compared to placebo, one-year treatment with melatonin did not affect postural balance or risk of falls. Furthermore, no significant changes between groups were observed in muscle strength in neither upper- nor lower extremities. Treatment did not affect quality of life or sleep. However, in the subgroup of women with sleep disturbances at baseline, a trend towards an improved sleep quality was seen (p = 0.08).

Conclusion: Treatment with melatonin is safe in postmenopausal women with osteopenia. There is no hangover effect affecting balance- and muscle function following the intake of melatonin. In women with a good quality of sleep, melatonin has no effect, however in poor quality of sleep, small doses of melatonin trended towards improving the quality.

Trial registration: (# NCT01690000).

No MeSH data available.


Related in: MedlinePlus