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Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls.

Hua XP, Zhang XD, Kwong JS, Zeng XT, Zhang ZJ, Wei WL - Ther Clin Risk Manag (2015)

Bottom Line: The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89-1.30; AA vs GG: OR =1.15, 95% CI =0.59-2.25; GA vs GG: OR =1.14, 95% CI =0.88-1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56-2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90-1.38).In the subgroup analyses, similar results were obtained with overall populations.The sensitivity analyses showed that the overall results were robust.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, People's Republic of China.

ABSTRACT

Background: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α) gene G-238A polymorphism and risk of coronary artery disease (CAD) using a meta-analytical approach.

Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ) independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs) and their 95% confidence intervals (CIs).

Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89-1.30; AA vs GG: OR =1.15, 95% CI =0.59-2.25; GA vs GG: OR =1.14, 95% CI =0.88-1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56-2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90-1.38). In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.

Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism might not be associated with CAD risk.

No MeSH data available.


Related in: MedlinePlus

Forest plot of sensitivity analysis by omitting a single study each time of overall population of TNF-α G-238A polymorphism and CAD risk (A vs G model).Notes: Herrmann I 1998, the study conducted in Northern Ireland; Herrmann F 1998, the study conducted in France.Abbreviations: TNF-α, tumor necrosis factor-alpha; CAD, coronary artery disease; CI, confidence interval.
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f3-tcrm-11-1429: Forest plot of sensitivity analysis by omitting a single study each time of overall population of TNF-α G-238A polymorphism and CAD risk (A vs G model).Notes: Herrmann I 1998, the study conducted in Northern Ireland; Herrmann F 1998, the study conducted in France.Abbreviations: TNF-α, tumor necrosis factor-alpha; CAD, coronary artery disease; CI, confidence interval.

Mentions: After being stratified by ethnicity, the results of Asian and Caucasian populations were similar to that of the overall population. The studies in HWE also revealed nonsignificant association. Table 2 shows the overall and subgroup analyses results of G-238A polymorphism and CAD risk. The sensitivity analysis showed that none of the included eleven studies dramatically influenced the pooled results under all the five genetic models (Figure 3).


Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls.

Hua XP, Zhang XD, Kwong JS, Zeng XT, Zhang ZJ, Wei WL - Ther Clin Risk Manag (2015)

Forest plot of sensitivity analysis by omitting a single study each time of overall population of TNF-α G-238A polymorphism and CAD risk (A vs G model).Notes: Herrmann I 1998, the study conducted in Northern Ireland; Herrmann F 1998, the study conducted in France.Abbreviations: TNF-α, tumor necrosis factor-alpha; CAD, coronary artery disease; CI, confidence interval.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590639&req=5

f3-tcrm-11-1429: Forest plot of sensitivity analysis by omitting a single study each time of overall population of TNF-α G-238A polymorphism and CAD risk (A vs G model).Notes: Herrmann I 1998, the study conducted in Northern Ireland; Herrmann F 1998, the study conducted in France.Abbreviations: TNF-α, tumor necrosis factor-alpha; CAD, coronary artery disease; CI, confidence interval.
Mentions: After being stratified by ethnicity, the results of Asian and Caucasian populations were similar to that of the overall population. The studies in HWE also revealed nonsignificant association. Table 2 shows the overall and subgroup analyses results of G-238A polymorphism and CAD risk. The sensitivity analysis showed that none of the included eleven studies dramatically influenced the pooled results under all the five genetic models (Figure 3).

Bottom Line: The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89-1.30; AA vs GG: OR =1.15, 95% CI =0.59-2.25; GA vs GG: OR =1.14, 95% CI =0.88-1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56-2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90-1.38).In the subgroup analyses, similar results were obtained with overall populations.The sensitivity analyses showed that the overall results were robust.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, People's Republic of China.

ABSTRACT

Background: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α) gene G-238A polymorphism and risk of coronary artery disease (CAD) using a meta-analytical approach.

Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ) independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs) and their 95% confidence intervals (CIs).

Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89-1.30; AA vs GG: OR =1.15, 95% CI =0.59-2.25; GA vs GG: OR =1.14, 95% CI =0.88-1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56-2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90-1.38). In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.

Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism might not be associated with CAD risk.

No MeSH data available.


Related in: MedlinePlus