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The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis.

Wang J, Dan G, Zhao J, Ding Y, Ye F, Sun H, Jiang F, Cheng J, Yuan F, Zou Z - Onco Targets Ther (2015)

Bottom Line: Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough.The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology, School of Preventive Medicine, The Third Military Medical University, Chongqing, People's Republic of China.

ABSTRACT

Background: MicroRNA-34a (miR-34a) is a potential prognostic factor for survival in patients with several types of cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-34a expression in the prognosis of patients' overall survival.

Materials and methods: The present systematic review and meta-analysis of 15 researches included 2,597 patients. Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough. Subgroup analysis results showed miR-34a was an ideal predictor for digestive system cancer (OS, HR =0.50, 95% confidence interval: 0.25-0.99, P=0.048). The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.

Conclusion: This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

No MeSH data available.


Related in: MedlinePlus

Forrest plots of studies evaluating hazard ratios of high miR-34a expression. The random effects analysis model showed the pooled HR for overall survival is 0.76 with 95% CI: 0.55–1.06, and P-value is 0.105.Note: Weights are from random effects analysis.Abbreviations: CI, confidence interval; miR-34a, microRNA-34a; OS, overall survival; HR, hazard ratio; ID, identification.
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f2-ott-8-2709: Forrest plots of studies evaluating hazard ratios of high miR-34a expression. The random effects analysis model showed the pooled HR for overall survival is 0.76 with 95% CI: 0.55–1.06, and P-value is 0.105.Note: Weights are from random effects analysis.Abbreviations: CI, confidence interval; miR-34a, microRNA-34a; OS, overall survival; HR, hazard ratio; ID, identification.

Mentions: HRs could only be retrieved from the unique study, such as DSS (HR =0, 95% CI: 0) in sinonasal squamous cell carcinoma, cancer-specific survival in breast cancer (5-year HR =0.88, 0.65–1.88, P=0.573; 10-year HR =0.67, 95% CI: 0.50–0.89, P=0.073), and EFS (HR =0.491, 95% CI: 0.40–0.60, P=0.0004). If more than two researches fall into one category, the HRs were pooled. For studies evaluating OS of patients, a pooled HR and its 95% CI were calculated with a random model because of the high heterogeneity between studies (P=0.000, I2=79.4%). The result showed that higher expression of miR-34a may predict good OS, and the pooled HR was 0.76 (95% CI: 0.55–1.06); however, the effect did not reach the level of statistical significance (P=0.105) (Figure 2).


The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis.

Wang J, Dan G, Zhao J, Ding Y, Ye F, Sun H, Jiang F, Cheng J, Yuan F, Zou Z - Onco Targets Ther (2015)

Forrest plots of studies evaluating hazard ratios of high miR-34a expression. The random effects analysis model showed the pooled HR for overall survival is 0.76 with 95% CI: 0.55–1.06, and P-value is 0.105.Note: Weights are from random effects analysis.Abbreviations: CI, confidence interval; miR-34a, microRNA-34a; OS, overall survival; HR, hazard ratio; ID, identification.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590634&req=5

f2-ott-8-2709: Forrest plots of studies evaluating hazard ratios of high miR-34a expression. The random effects analysis model showed the pooled HR for overall survival is 0.76 with 95% CI: 0.55–1.06, and P-value is 0.105.Note: Weights are from random effects analysis.Abbreviations: CI, confidence interval; miR-34a, microRNA-34a; OS, overall survival; HR, hazard ratio; ID, identification.
Mentions: HRs could only be retrieved from the unique study, such as DSS (HR =0, 95% CI: 0) in sinonasal squamous cell carcinoma, cancer-specific survival in breast cancer (5-year HR =0.88, 0.65–1.88, P=0.573; 10-year HR =0.67, 95% CI: 0.50–0.89, P=0.073), and EFS (HR =0.491, 95% CI: 0.40–0.60, P=0.0004). If more than two researches fall into one category, the HRs were pooled. For studies evaluating OS of patients, a pooled HR and its 95% CI were calculated with a random model because of the high heterogeneity between studies (P=0.000, I2=79.4%). The result showed that higher expression of miR-34a may predict good OS, and the pooled HR was 0.76 (95% CI: 0.55–1.06); however, the effect did not reach the level of statistical significance (P=0.105) (Figure 2).

Bottom Line: Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough.The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology, School of Preventive Medicine, The Third Military Medical University, Chongqing, People's Republic of China.

ABSTRACT

Background: MicroRNA-34a (miR-34a) is a potential prognostic factor for survival in patients with several types of cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-34a expression in the prognosis of patients' overall survival.

Materials and methods: The present systematic review and meta-analysis of 15 researches included 2,597 patients. Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough. Subgroup analysis results showed miR-34a was an ideal predictor for digestive system cancer (OS, HR =0.50, 95% confidence interval: 0.25-0.99, P=0.048). The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.

Conclusion: This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

No MeSH data available.


Related in: MedlinePlus