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The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis.

Wang J, Dan G, Zhao J, Ding Y, Ye F, Sun H, Jiang F, Cheng J, Yuan F, Zou Z - Onco Targets Ther (2015)

Bottom Line: Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough.The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology, School of Preventive Medicine, The Third Military Medical University, Chongqing, People's Republic of China.

ABSTRACT

Background: MicroRNA-34a (miR-34a) is a potential prognostic factor for survival in patients with several types of cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-34a expression in the prognosis of patients' overall survival.

Materials and methods: The present systematic review and meta-analysis of 15 researches included 2,597 patients. Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough. Subgroup analysis results showed miR-34a was an ideal predictor for digestive system cancer (OS, HR =0.50, 95% confidence interval: 0.25-0.99, P=0.048). The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.

Conclusion: This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

No MeSH data available.


Related in: MedlinePlus

The flowchart showed the selection of studies for meta-analysis.Abbreviation: miR-34a, microRNA-34a.
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f1-ott-8-2709: The flowchart showed the selection of studies for meta-analysis.Abbreviation: miR-34a, microRNA-34a.

Mentions: We collected 1,005 records from PubMed and 2,986 from Embase in the primary research with different keywords and excluded 3,015 duplicates from the initial records. After screening the titles, abstracts, publication types, and full texts of the remaining 1,005 records, 990 records were excluded according to the listed criteria. Then, the references of the remaining 15 qualified records were manually checked, and there was no additional record found in the cross-references. So, we got the 15 records included in our analysis.16–30Figure 1 showed the flow diagram of candidate selection records in our study.


The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis.

Wang J, Dan G, Zhao J, Ding Y, Ye F, Sun H, Jiang F, Cheng J, Yuan F, Zou Z - Onco Targets Ther (2015)

The flowchart showed the selection of studies for meta-analysis.Abbreviation: miR-34a, microRNA-34a.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590634&req=5

f1-ott-8-2709: The flowchart showed the selection of studies for meta-analysis.Abbreviation: miR-34a, microRNA-34a.
Mentions: We collected 1,005 records from PubMed and 2,986 from Embase in the primary research with different keywords and excluded 3,015 duplicates from the initial records. After screening the titles, abstracts, publication types, and full texts of the remaining 1,005 records, 990 records were excluded according to the listed criteria. Then, the references of the remaining 15 qualified records were manually checked, and there was no additional record found in the cross-references. So, we got the 15 records included in our analysis.16–30Figure 1 showed the flow diagram of candidate selection records in our study.

Bottom Line: Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough.The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology, School of Preventive Medicine, The Third Military Medical University, Chongqing, People's Republic of China.

ABSTRACT

Background: MicroRNA-34a (miR-34a) is a potential prognostic factor for survival in patients with several types of cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-34a expression in the prognosis of patients' overall survival.

Materials and methods: The present systematic review and meta-analysis of 15 researches included 2,597 patients. Overexpression of miR-34a may predict good overall survival ([OS], HR =0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough. Subgroup analysis results showed miR-34a was an ideal predictor for digestive system cancer (OS, HR =0.50, 95% confidence interval: 0.25-0.99, P=0.048). The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences.

Conclusion: This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.

No MeSH data available.


Related in: MedlinePlus