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Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression.

Zheng H, Nong Z, Lu G - Med. Sci. Monit. (2015)

Bottom Line: The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion.Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China (mainland).

ABSTRACT

Background: Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.

Material and methods: Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.

Results: Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).

Conclusions: Nrf2 expression is positively correlated with invasive gastric cancer, suggesting its utility as a predictive index for unfavorable prognosis.

No MeSH data available.


Related in: MedlinePlus

Postoperative survival rates of Nrf2-positive and Nrf2-negative patients.
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f3-medscimonit-21-2893: Postoperative survival rates of Nrf2-positive and Nrf2-negative patients.

Mentions: Using Kaplan-Meier method, we found that the overall survival rate in Nrf2-positive patients was significantly lower than that in Nrf2-negative patients (61% vs. 79%, p<0.01, Figure 3). Significant correlation factors of patient survival rate include invasive depth, tumor size, lymph node metastasis, TNM stage, and lymph tube infiltration, by univariate analysis. A further multivariate analysis indicated lymph node metastasis as an independent prognostic index (Table 3).


Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression.

Zheng H, Nong Z, Lu G - Med. Sci. Monit. (2015)

Postoperative survival rates of Nrf2-positive and Nrf2-negative patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590579&req=5

f3-medscimonit-21-2893: Postoperative survival rates of Nrf2-positive and Nrf2-negative patients.
Mentions: Using Kaplan-Meier method, we found that the overall survival rate in Nrf2-positive patients was significantly lower than that in Nrf2-negative patients (61% vs. 79%, p<0.01, Figure 3). Significant correlation factors of patient survival rate include invasive depth, tumor size, lymph node metastasis, TNM stage, and lymph tube infiltration, by univariate analysis. A further multivariate analysis indicated lymph node metastasis as an independent prognostic index (Table 3).

Bottom Line: The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion.Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China (mainland).

ABSTRACT

Background: Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.

Material and methods: Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.

Results: Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).

Conclusions: Nrf2 expression is positively correlated with invasive gastric cancer, suggesting its utility as a predictive index for unfavorable prognosis.

No MeSH data available.


Related in: MedlinePlus