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Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.

GrĂ¼ndemann J, Clark BA - Cell Rep (2015)

Bottom Line: This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier.Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels.We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

View Article: PubMed Central - PubMed

Affiliation: Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

No MeSH data available.


Related in: MedlinePlus

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Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.

GrĂ¼ndemann J, Clark BA - Cell Rep (2015)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590545&req=5

Bottom Line: This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier.Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels.We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

View Article: PubMed Central - PubMed

Affiliation: Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

No MeSH data available.


Related in: MedlinePlus