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Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.

GrĂ¼ndemann J, Clark BA - Cell Rep (2015)

Bottom Line: Functional connectivity between brain regions relies on long-range signaling by myelinated axons.This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier.We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

View Article: PubMed Central - PubMed

Affiliation: Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

No MeSH data available.


Related in: MedlinePlus

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Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.

GrĂ¼ndemann J, Clark BA - Cell Rep (2015)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590545&req=5

Bottom Line: Functional connectivity between brain regions relies on long-range signaling by myelinated axons.This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier.We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

View Article: PubMed Central - PubMed

Affiliation: Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

No MeSH data available.


Related in: MedlinePlus