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How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.

George J, Rapsomaniki E, Pujades-Rodriguez M, Shah AD, Denaxas S, Herrett E, Smeeth L, Timmis A, Hemingway H - Circulation (2015)

Bottom Line: We compared the incidence of 12 cardiac, cerebrovascular, and peripheral vascular diseases in women and men at different ages.The majority of initial presentations of CVD are neither myocardial infarction nor ischemic stroke, yet most primary prevention studies focus on these presentations.Sex has differing associations with different CVDs, with implications for risk prediction and management strategies.

View Article: PubMed Central - PubMed

Affiliation: From Farr Institute of Health Informatics Research (London), University College London, United Kingdom (J.G., M.P.-R., A.D.S., S.D., H.H.); Worldwide Clinical Trials, Nottingham, United Kingdom (E.R.); Farr Institute of Health Informatics Research (London), London School of Hygiene & Tropical Medicine, United Kingdom (E.H., L.S.); and Farr Institute of Health Informatics Research (London) and Barts National Institute for Health Research Cardiovascular Biomedical Research Unit, Queen Mary University of London, United Kingdom (A.T.). j.george@ucl.ac.uk.

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Age and sex distribution of 60 155 events in men and 54 704 in women representing the initial presentation of a wide range of CVDs. CHD indicates coronary heart disease; CVD, cardiovascular disease; NOS, not otherwise specified; and SCD, sudden cardiac death.
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Figure 1: Age and sex distribution of 60 155 events in men and 54 704 in women representing the initial presentation of a wide range of CVDs. CHD indicates coronary heart disease; CVD, cardiovascular disease; NOS, not otherwise specified; and SCD, sudden cardiac death.

Mentions: Over a 6-year median follow-up (interquartile range, 2–10), 114 859 initial CVD presentations were observed (52.3% in men), among which nonfatal MI, UCD, and ischemic or NOS stroke together accounted for 32.5%. The proportion of events varied by sex and age group (Figure 1; Table I in the online-only Data Supplement). The most frequent initial CVD presentation for men was nonfatal MI, which accounted for 27.9% of events in the 30 to 39 age group and more than double the proportion in women in the same age group (11.2%). This proportion declined in men as age increased, becoming similar to that in women in the >80 age group. In contrast, stable angina and unstable angina accounted for similar proportions of initial presentations in both men and women and declined with age. Although evident in younger age groups, heart failure and ischemic stroke as an initial presentation started to increase in both sexes at age 60 to form the 2 most common initial presentations at age >80.


How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.

George J, Rapsomaniki E, Pujades-Rodriguez M, Shah AD, Denaxas S, Herrett E, Smeeth L, Timmis A, Hemingway H - Circulation (2015)

Age and sex distribution of 60 155 events in men and 54 704 in women representing the initial presentation of a wide range of CVDs. CHD indicates coronary heart disease; CVD, cardiovascular disease; NOS, not otherwise specified; and SCD, sudden cardiac death.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590518&req=5

Figure 1: Age and sex distribution of 60 155 events in men and 54 704 in women representing the initial presentation of a wide range of CVDs. CHD indicates coronary heart disease; CVD, cardiovascular disease; NOS, not otherwise specified; and SCD, sudden cardiac death.
Mentions: Over a 6-year median follow-up (interquartile range, 2–10), 114 859 initial CVD presentations were observed (52.3% in men), among which nonfatal MI, UCD, and ischemic or NOS stroke together accounted for 32.5%. The proportion of events varied by sex and age group (Figure 1; Table I in the online-only Data Supplement). The most frequent initial CVD presentation for men was nonfatal MI, which accounted for 27.9% of events in the 30 to 39 age group and more than double the proportion in women in the same age group (11.2%). This proportion declined in men as age increased, becoming similar to that in women in the >80 age group. In contrast, stable angina and unstable angina accounted for similar proportions of initial presentations in both men and women and declined with age. Although evident in younger age groups, heart failure and ischemic stroke as an initial presentation started to increase in both sexes at age 60 to form the 2 most common initial presentations at age >80.

Bottom Line: We compared the incidence of 12 cardiac, cerebrovascular, and peripheral vascular diseases in women and men at different ages.The majority of initial presentations of CVD are neither myocardial infarction nor ischemic stroke, yet most primary prevention studies focus on these presentations.Sex has differing associations with different CVDs, with implications for risk prediction and management strategies.

View Article: PubMed Central - PubMed

Affiliation: From Farr Institute of Health Informatics Research (London), University College London, United Kingdom (J.G., M.P.-R., A.D.S., S.D., H.H.); Worldwide Clinical Trials, Nottingham, United Kingdom (E.R.); Farr Institute of Health Informatics Research (London), London School of Hygiene & Tropical Medicine, United Kingdom (E.H., L.S.); and Farr Institute of Health Informatics Research (London) and Barts National Institute for Health Research Cardiovascular Biomedical Research Unit, Queen Mary University of London, United Kingdom (A.T.). j.george@ucl.ac.uk.

Show MeSH
Related in: MedlinePlus