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The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: a randomized, double-blind, placebo-controlled study.

Shahar S, Aziz AF, Ismail SN, Yahya HM, Din NC, Manaf ZA, Badrasawi MM - Clin Interv Aging (2015)

Bottom Line: However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered.While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004).Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

View Article: PubMed Central - PubMed

Affiliation: Dietetics Programme, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Polygonum minus (PM) or locally known in Malaysia, as "kesum" is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia.

Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6.

Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms.

Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

No MeSH data available.


Related in: MedlinePlus

(A) The mean score of Full IQ of WASI at baseline, week 3, and week 6 among subjects with good mood according to study groups. (B) The percentage of mean change for Full IQ of WASI from baseline to week 3 and week 6 among subjects with mood disturbance according to study groups.Notes: A, placebo group; B, Polygonum minus group. Good mood = POMS ≤15. *P<0.05 independent t-test.Abbreviations: POMS, Profile of Mood States; WASI, Wechsler Abbreviated Scale of Intelligence.
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f4-cia-10-1505: (A) The mean score of Full IQ of WASI at baseline, week 3, and week 6 among subjects with good mood according to study groups. (B) The percentage of mean change for Full IQ of WASI from baseline to week 3 and week 6 among subjects with mood disturbance according to study groups.Notes: A, placebo group; B, Polygonum minus group. Good mood = POMS ≤15. *P<0.05 independent t-test.Abbreviations: POMS, Profile of Mood States; WASI, Wechsler Abbreviated Scale of Intelligence.

Mentions: At baseline, there were no significant differences between groups on cognitive and psychosocial status. There was an interaction effect for Digit Span scale score (P<0.05) among subjects with mood disturbance, of which the mean of Digit Span scale improved among subjects intervention group when compared with placebo (Table 3). The mean of Digit Span scale increased among subjects in PM supplemented group from 9±2.2 at baseline to 10±1.5 at week 3 and maintained at 10±1.9 at week 6. While, among the placebo group, the value increased from 7±1.4 at baseline to 7±1.4 at week 3, but reduced to 9±2.9 at week 6 (Figure 2A). Furthermore, percentage of change of Digit Span continuously increased among the PM supplemented group, but it increased then decreased in the placebo group within subjects with mood disturbance (Figure 2B). Among those with good mood, there was a significant interaction effect for Verbal IQ (P<0.05) and Full Scale IQ of WASI (P<0.05) (Table 3). As shown in Figure 3A, within those with good, subjects supplemented with PM, the mean score of Verbal IQ improved from 107±4.4 at baseline to 110±8.6 at week 3 and slightly reduced to 109±6.7 at week 6, but the later value still higher than baseline (Figure 3A and B). Such increment was not notably seen in the placebo group. With respect to the Full Scale IQ of WASI, the mean score increased sharply from 105±10.4 at baseline in PM supplemented group to 115±9.4 at week 3 but slightly reduced to 115±9.4 at week 6, but the later value still higher than baseline. However, such a sharp rise was not noted in the placebo group (Figure 4A). Thus, the percentage of change increased by 9% at 3 week and slightly reduced to 7.2% at week 6 in the PM supplemented group, when compared with a slight of increment only between 1% and 2% in the placebo group (Figure 4B). The difference in percentage of change between groups at week 3 was significantly differed.


The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: a randomized, double-blind, placebo-controlled study.

Shahar S, Aziz AF, Ismail SN, Yahya HM, Din NC, Manaf ZA, Badrasawi MM - Clin Interv Aging (2015)

(A) The mean score of Full IQ of WASI at baseline, week 3, and week 6 among subjects with good mood according to study groups. (B) The percentage of mean change for Full IQ of WASI from baseline to week 3 and week 6 among subjects with mood disturbance according to study groups.Notes: A, placebo group; B, Polygonum minus group. Good mood = POMS ≤15. *P<0.05 independent t-test.Abbreviations: POMS, Profile of Mood States; WASI, Wechsler Abbreviated Scale of Intelligence.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590418&req=5

f4-cia-10-1505: (A) The mean score of Full IQ of WASI at baseline, week 3, and week 6 among subjects with good mood according to study groups. (B) The percentage of mean change for Full IQ of WASI from baseline to week 3 and week 6 among subjects with mood disturbance according to study groups.Notes: A, placebo group; B, Polygonum minus group. Good mood = POMS ≤15. *P<0.05 independent t-test.Abbreviations: POMS, Profile of Mood States; WASI, Wechsler Abbreviated Scale of Intelligence.
Mentions: At baseline, there were no significant differences between groups on cognitive and psychosocial status. There was an interaction effect for Digit Span scale score (P<0.05) among subjects with mood disturbance, of which the mean of Digit Span scale improved among subjects intervention group when compared with placebo (Table 3). The mean of Digit Span scale increased among subjects in PM supplemented group from 9±2.2 at baseline to 10±1.5 at week 3 and maintained at 10±1.9 at week 6. While, among the placebo group, the value increased from 7±1.4 at baseline to 7±1.4 at week 3, but reduced to 9±2.9 at week 6 (Figure 2A). Furthermore, percentage of change of Digit Span continuously increased among the PM supplemented group, but it increased then decreased in the placebo group within subjects with mood disturbance (Figure 2B). Among those with good mood, there was a significant interaction effect for Verbal IQ (P<0.05) and Full Scale IQ of WASI (P<0.05) (Table 3). As shown in Figure 3A, within those with good, subjects supplemented with PM, the mean score of Verbal IQ improved from 107±4.4 at baseline to 110±8.6 at week 3 and slightly reduced to 109±6.7 at week 6, but the later value still higher than baseline (Figure 3A and B). Such increment was not notably seen in the placebo group. With respect to the Full Scale IQ of WASI, the mean score increased sharply from 105±10.4 at baseline in PM supplemented group to 115±9.4 at week 3 but slightly reduced to 115±9.4 at week 6, but the later value still higher than baseline. However, such a sharp rise was not noted in the placebo group (Figure 4A). Thus, the percentage of change increased by 9% at 3 week and slightly reduced to 7.2% at week 6 in the PM supplemented group, when compared with a slight of increment only between 1% and 2% in the placebo group (Figure 4B). The difference in percentage of change between groups at week 3 was significantly differed.

Bottom Line: However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered.While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004).Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

View Article: PubMed Central - PubMed

Affiliation: Dietetics Programme, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Polygonum minus (PM) or locally known in Malaysia, as "kesum" is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia.

Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6.

Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms.

Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

No MeSH data available.


Related in: MedlinePlus