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The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis.

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S - Drug Des Devel Ther (2015)

Bottom Line: Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated by fixed-effect models or random-effect models.Publication bias was detected by Egger's test and Begg's test.The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

ABSTRACT

Background: Interleukin-17 (IL-17) is a family of emerged pro-inflammatory cytokines. The IL-17A and IL-17F are two important members of IL-17 family. Previous studies have shown that the functional IL-17A G-197A and IL-17F 7488T/C polymorphisms may contribute to susceptibility to cancer but the results were inconclusive. This meta-analysis was performed to determine the exact association between IL-17 polymorphisms and cancer risk.

Methods: Online databases were searched to identify eligible case-control studies. Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated by fixed-effect models or random-effect models. Publication bias was detected by Egger's test and Begg's test.

Results: Nine eligible case-control studies of IL-17A G-197A and seven studies of IL-17F 7488T/C, including 3,181 cases and 4,005 controls, were identified. Pooled analysis suggested the variant IL-17A-197A allele was associated with increased risk cancer (GA/AA vs GG, OR =1.27, 95% CI: 1.15, 1.41, P heterogeneity =0.374; and A vs G, OR =1.30, 95% CI: 1.17, 1.45, P heterogeneity =0.021). For IL-17F 7488T/C, the homozygote 7488CC genotype significantly increased risk of cancer (CC vs TC/TT, OR =1.36, 95% CI: 0.97, 1.91, P heterogeneity =0.875; and CC vs TT, OR =1.39, 95% CI: 1.03, 1.88, P heterogeneity =0.979), especially for gastric cancer.

Conclusion: The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer.

No MeSH data available.


Related in: MedlinePlus

Flowchart of study selection.
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Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4590416&req=5

f1-dddt-9-5159: Flowchart of study selection.

Mentions: The process of study selection is shown in Figure 1. In summary, nine studies10–12,15–20 about IL-17A G-197A and seven studies of IL-17F 7488T/C were identified. The baseline characteristics of eligible studies are shown in Table 1. Of note, all eligible studies were conducted in Asia.


The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis.

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S - Drug Des Devel Ther (2015)

Flowchart of study selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590416&req=5

f1-dddt-9-5159: Flowchart of study selection.
Mentions: The process of study selection is shown in Figure 1. In summary, nine studies10–12,15–20 about IL-17A G-197A and seven studies of IL-17F 7488T/C were identified. The baseline characteristics of eligible studies are shown in Table 1. Of note, all eligible studies were conducted in Asia.

Bottom Line: Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated by fixed-effect models or random-effect models.Publication bias was detected by Egger's test and Begg's test.The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

ABSTRACT

Background: Interleukin-17 (IL-17) is a family of emerged pro-inflammatory cytokines. The IL-17A and IL-17F are two important members of IL-17 family. Previous studies have shown that the functional IL-17A G-197A and IL-17F 7488T/C polymorphisms may contribute to susceptibility to cancer but the results were inconclusive. This meta-analysis was performed to determine the exact association between IL-17 polymorphisms and cancer risk.

Methods: Online databases were searched to identify eligible case-control studies. Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated by fixed-effect models or random-effect models. Publication bias was detected by Egger's test and Begg's test.

Results: Nine eligible case-control studies of IL-17A G-197A and seven studies of IL-17F 7488T/C, including 3,181 cases and 4,005 controls, were identified. Pooled analysis suggested the variant IL-17A-197A allele was associated with increased risk cancer (GA/AA vs GG, OR =1.27, 95% CI: 1.15, 1.41, P heterogeneity =0.374; and A vs G, OR =1.30, 95% CI: 1.17, 1.45, P heterogeneity =0.021). For IL-17F 7488T/C, the homozygote 7488CC genotype significantly increased risk of cancer (CC vs TC/TT, OR =1.36, 95% CI: 0.97, 1.91, P heterogeneity =0.875; and CC vs TT, OR =1.39, 95% CI: 1.03, 1.88, P heterogeneity =0.979), especially for gastric cancer.

Conclusion: The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer.

No MeSH data available.


Related in: MedlinePlus