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Can living donor liver transplantation offer similar outcomes to deceased donor liver transplantation using expanded selection criteria for hepatocellular carcinoma?

Chen LP, Li C, Wen TF, Yan LN, Li B, Yang JY - Pak J Med Sci (2015 Jul-Aug)

Bottom Line: Clinical data of LDLT recipients and DDLT recipients were compared.The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.

View Article: PubMed Central - PubMed

Affiliation: Li-Ping Chen, Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu-610041, China. Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.

ABSTRACT

Objective: To compare the outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC) in different selection criteria.

Methods: Data of patients with HCC who underwent liver transplantation between 2005 and 2013 at our center were reviewed. Clinical data of LDLT recipients and DDLT recipients were compared. The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.

Results: Data of 255 patients were retrospectively reviewed in this study. Seventeen DDLT recipient and 9 LDLT recipients died during the perioperative period. Among the remaining 229 recipients (NLDLT=66, NDDLT=163), 96 patients met the Milan criteria, 123 recipients met the UCSF criteria, 135 patients met the up-to-seven criteria, 216 patients met the Hangzhou criteria, and 229 recipients met the Chengdu criteria. The overall RFS and OS rates of the Milan recipients, the UCSF recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients after LDLT and DDLT were all similar.

Conclusion: Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.

No MeSH data available.


Related in: MedlinePlus

Comparison of the RFS (figure 2a) and OS (figure 2b) rates of LDLT and DDLT for patients with HCC within UCSF criteria. RFS (figure 2c) and OS (figure 2d) curves of LDLT versus DDLT for patients with HCC within up-to-seven criteria
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Figure 2: Comparison of the RFS (figure 2a) and OS (figure 2b) rates of LDLT and DDLT for patients with HCC within UCSF criteria. RFS (figure 2c) and OS (figure 2d) curves of LDLT versus DDLT for patients with HCC within up-to-seven criteria

Mentions: When the University of California San Francisco criteria was applied, 137 recipients, including 95 DDLT recipients and 42 LDLT recipients, fulfilled the selection criteria. The 1-, 3-, 5-year RFS of LDLT recipients were 89.2%, 83.0% and 83.0% respectively, which were slightly higher than the DDLT recipients (88.4%, 77.1% and 72.1% for 1-, 3-, 5-year RFS rates respectively). However, this difference didn’t reach statistical significance (Fig.2a, P=0.278). The 1-, 3-, 5-year OS rates of DDLT recipients were 86.3%, 70.9% and 66.0% respectively, whereas the 1-, 3-, 5-year OS rates of LDLT recipients were 88.1%, 74.9% and 71.8% respectively (Fig.2b, P=0.570).


Can living donor liver transplantation offer similar outcomes to deceased donor liver transplantation using expanded selection criteria for hepatocellular carcinoma?

Chen LP, Li C, Wen TF, Yan LN, Li B, Yang JY - Pak J Med Sci (2015 Jul-Aug)

Comparison of the RFS (figure 2a) and OS (figure 2b) rates of LDLT and DDLT for patients with HCC within UCSF criteria. RFS (figure 2c) and OS (figure 2d) curves of LDLT versus DDLT for patients with HCC within up-to-seven criteria
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590398&req=5

Figure 2: Comparison of the RFS (figure 2a) and OS (figure 2b) rates of LDLT and DDLT for patients with HCC within UCSF criteria. RFS (figure 2c) and OS (figure 2d) curves of LDLT versus DDLT for patients with HCC within up-to-seven criteria
Mentions: When the University of California San Francisco criteria was applied, 137 recipients, including 95 DDLT recipients and 42 LDLT recipients, fulfilled the selection criteria. The 1-, 3-, 5-year RFS of LDLT recipients were 89.2%, 83.0% and 83.0% respectively, which were slightly higher than the DDLT recipients (88.4%, 77.1% and 72.1% for 1-, 3-, 5-year RFS rates respectively). However, this difference didn’t reach statistical significance (Fig.2a, P=0.278). The 1-, 3-, 5-year OS rates of DDLT recipients were 86.3%, 70.9% and 66.0% respectively, whereas the 1-, 3-, 5-year OS rates of LDLT recipients were 88.1%, 74.9% and 71.8% respectively (Fig.2b, P=0.570).

Bottom Line: Clinical data of LDLT recipients and DDLT recipients were compared.The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.

View Article: PubMed Central - PubMed

Affiliation: Li-Ping Chen, Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu-610041, China. Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.

ABSTRACT

Objective: To compare the outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC) in different selection criteria.

Methods: Data of patients with HCC who underwent liver transplantation between 2005 and 2013 at our center were reviewed. Clinical data of LDLT recipients and DDLT recipients were compared. The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.

Results: Data of 255 patients were retrospectively reviewed in this study. Seventeen DDLT recipient and 9 LDLT recipients died during the perioperative period. Among the remaining 229 recipients (NLDLT=66, NDDLT=163), 96 patients met the Milan criteria, 123 recipients met the UCSF criteria, 135 patients met the up-to-seven criteria, 216 patients met the Hangzhou criteria, and 229 recipients met the Chengdu criteria. The overall RFS and OS rates of the Milan recipients, the UCSF recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients after LDLT and DDLT were all similar.

Conclusion: Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.

No MeSH data available.


Related in: MedlinePlus