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Association of smoking with restenosis and major adverse cardiac events after coronary stenting: A meta-analysis.

Hu RT, Liu J, Zhou Y, Hu BL - Pak J Med Sci (2015 Jul-Aug)

Bottom Line: Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation.Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43-3.06; I(2) = 21.6%).Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE.

View Article: PubMed Central - PubMed

Affiliation: Rui-ting Hu, MD. Minzu Affiliated Hospital of Guangxi Medical University, 530001 Nanning, China.

ABSTRACT

Background and objective: The association between smoking and clinical outcomes after coronary stenting is controversial. The aim of this meta-analysis was to assess the association between smoking and in stent restenosis (ISR), major adverse cardiac events (MACE), or major adverse cardiac and cerebrovascular events (MACCE) after coronary stenting.

Methods: A search for studies published before December 2014 was conducted in PubMed, Embase, and Cochrane library. An inverse random weighted meta-analysis was conducted using logarithm of the odds ratio (OR) and its standard error for each study.

Results: Ten studies investigated the association between smoking and ISR. Overall, smoking was not associated with ISR (OR: 1.05, 95% CI: 0.79-1.41; I(2) = 47.8%). Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation. Eight studies explored the association between smoking and MACE, but no association was found (OR: 0.92, 95% CI: 0.77-1.10; I(2) = 25.5%), and subgroup analysis revealed that no distinct difference was found between BMS and DES implantation. Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43-3.06; I(2) = 21.6%).

Conclusions: Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the association between smoking and MACCE.
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Figure 4: Meta-analysis of the association between smoking and MACCE.

Mentions: There was a significant association between smoking and MACCE after coronary stenting (OR: 2.08, 95% CI: 1.51–2.88), and no significant heterogeneity between the studies (I2 = 21.6%, P = 0.279). Fig.4. Egger’s test suggested little publication bias (P = 0.721).


Association of smoking with restenosis and major adverse cardiac events after coronary stenting: A meta-analysis.

Hu RT, Liu J, Zhou Y, Hu BL - Pak J Med Sci (2015 Jul-Aug)

Meta-analysis of the association between smoking and MACCE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590384&req=5

Figure 4: Meta-analysis of the association between smoking and MACCE.
Mentions: There was a significant association between smoking and MACCE after coronary stenting (OR: 2.08, 95% CI: 1.51–2.88), and no significant heterogeneity between the studies (I2 = 21.6%, P = 0.279). Fig.4. Egger’s test suggested little publication bias (P = 0.721).

Bottom Line: Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation.Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43-3.06; I(2) = 21.6%).Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE.

View Article: PubMed Central - PubMed

Affiliation: Rui-ting Hu, MD. Minzu Affiliated Hospital of Guangxi Medical University, 530001 Nanning, China.

ABSTRACT

Background and objective: The association between smoking and clinical outcomes after coronary stenting is controversial. The aim of this meta-analysis was to assess the association between smoking and in stent restenosis (ISR), major adverse cardiac events (MACE), or major adverse cardiac and cerebrovascular events (MACCE) after coronary stenting.

Methods: A search for studies published before December 2014 was conducted in PubMed, Embase, and Cochrane library. An inverse random weighted meta-analysis was conducted using logarithm of the odds ratio (OR) and its standard error for each study.

Results: Ten studies investigated the association between smoking and ISR. Overall, smoking was not associated with ISR (OR: 1.05, 95% CI: 0.79-1.41; I(2) = 47.8%). Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation. Eight studies explored the association between smoking and MACE, but no association was found (OR: 0.92, 95% CI: 0.77-1.10; I(2) = 25.5%), and subgroup analysis revealed that no distinct difference was found between BMS and DES implantation. Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43-3.06; I(2) = 21.6%).

Conclusions: Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE.

No MeSH data available.


Related in: MedlinePlus