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Effects of a helium/oxygen mixture on individuals' lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases.

Häussermann S, Schulze A, Katz IM, Martin AR, Herpich C, Hunger T, Texereau J - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate.However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Inamed GmbH, Gauting, Germany.

ABSTRACT

Background: Helium/oxygen therapies have been studied as a means to reduce the symptoms of obstructive lung diseases with inconclusive results in clinical trials. To better understand this variability in results, an exploratory physiological study was performed comparing the effects of helium/oxygen mixture (78%/22%) to that of medical air.

Methods: The gas mixtures were administered to healthy, asthmatic, and chronic obstructive pulmonary disease (COPD) participants, both moderate and severe (6 participants in each disease group, a total of 30); at rest and during submaximal cycling exercise with equivalent work rates. Measurements of ventilatory parameters, forced spirometry, and ergospirometry were obtained.

Results: There was no statistical difference in ventilatory and cardiac responses to breathing helium/oxygen during submaximal exercise. For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate. However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.

Conclusion: The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

No MeSH data available.


Related in: MedlinePlus

The change in metabolic cost of breathing from air to He/O2 for each subject and categorized by subject group plotted as a function of IC% predicted.Note: The dashed line at 0 is the indicator of no benefit.Abbreviations: COPD, chronic obstructive pulmonary disease; IC%, inspiratory capacity percent.
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f7-copd-10-1987: The change in metabolic cost of breathing from air to He/O2 for each subject and categorized by subject group plotted as a function of IC% predicted.Note: The dashed line at 0 is the indicator of no benefit.Abbreviations: COPD, chronic obstructive pulmonary disease; IC%, inspiratory capacity percent.

Mentions: Figure 7 shows the percent change in the metabolic cost of breathing in terms of going from air to He/O2 for each subject and categorized by subject group plotted as a function of inspiratory capacity percent predicted (IC%). A positive change indicates a benefit to breathing the He/O2 mixture. The ratio represents unit volume of gas delivered to the lungs per unit energy expended. Thus, to increase this ratio going from air to helium/oxygen, with the exercise being the same, indicates that the change in gas mixture benefits the patient. Furthermore, while the effect of He/O2 has no direct effect on the elastic component of the work of breathing (ie, the work required to expand the lung and chest wall) reduced operational lung volume due to lower resistance during exhalation could in turn reduce the work required for inhalation.


Effects of a helium/oxygen mixture on individuals' lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases.

Häussermann S, Schulze A, Katz IM, Martin AR, Herpich C, Hunger T, Texereau J - Int J Chron Obstruct Pulmon Dis (2015)

The change in metabolic cost of breathing from air to He/O2 for each subject and categorized by subject group plotted as a function of IC% predicted.Note: The dashed line at 0 is the indicator of no benefit.Abbreviations: COPD, chronic obstructive pulmonary disease; IC%, inspiratory capacity percent.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590345&req=5

f7-copd-10-1987: The change in metabolic cost of breathing from air to He/O2 for each subject and categorized by subject group plotted as a function of IC% predicted.Note: The dashed line at 0 is the indicator of no benefit.Abbreviations: COPD, chronic obstructive pulmonary disease; IC%, inspiratory capacity percent.
Mentions: Figure 7 shows the percent change in the metabolic cost of breathing in terms of going from air to He/O2 for each subject and categorized by subject group plotted as a function of inspiratory capacity percent predicted (IC%). A positive change indicates a benefit to breathing the He/O2 mixture. The ratio represents unit volume of gas delivered to the lungs per unit energy expended. Thus, to increase this ratio going from air to helium/oxygen, with the exercise being the same, indicates that the change in gas mixture benefits the patient. Furthermore, while the effect of He/O2 has no direct effect on the elastic component of the work of breathing (ie, the work required to expand the lung and chest wall) reduced operational lung volume due to lower resistance during exhalation could in turn reduce the work required for inhalation.

Bottom Line: For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate.However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Inamed GmbH, Gauting, Germany.

ABSTRACT

Background: Helium/oxygen therapies have been studied as a means to reduce the symptoms of obstructive lung diseases with inconclusive results in clinical trials. To better understand this variability in results, an exploratory physiological study was performed comparing the effects of helium/oxygen mixture (78%/22%) to that of medical air.

Methods: The gas mixtures were administered to healthy, asthmatic, and chronic obstructive pulmonary disease (COPD) participants, both moderate and severe (6 participants in each disease group, a total of 30); at rest and during submaximal cycling exercise with equivalent work rates. Measurements of ventilatory parameters, forced spirometry, and ergospirometry were obtained.

Results: There was no statistical difference in ventilatory and cardiac responses to breathing helium/oxygen during submaximal exercise. For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate. However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.

Conclusion: The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

No MeSH data available.


Related in: MedlinePlus