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Effects of a helium/oxygen mixture on individuals' lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases.

Häussermann S, Schulze A, Katz IM, Martin AR, Herpich C, Hunger T, Texereau J - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate.However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Inamed GmbH, Gauting, Germany.

ABSTRACT

Background: Helium/oxygen therapies have been studied as a means to reduce the symptoms of obstructive lung diseases with inconclusive results in clinical trials. To better understand this variability in results, an exploratory physiological study was performed comparing the effects of helium/oxygen mixture (78%/22%) to that of medical air.

Methods: The gas mixtures were administered to healthy, asthmatic, and chronic obstructive pulmonary disease (COPD) participants, both moderate and severe (6 participants in each disease group, a total of 30); at rest and during submaximal cycling exercise with equivalent work rates. Measurements of ventilatory parameters, forced spirometry, and ergospirometry were obtained.

Results: There was no statistical difference in ventilatory and cardiac responses to breathing helium/oxygen during submaximal exercise. For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate. However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.

Conclusion: The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

No MeSH data available.


Related in: MedlinePlus

Average MET after submaximal exercise for each subject group.Note: The error bars represent standard deviation.Abbreviation: MET, metabolic equivalent.
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f3-copd-10-1987: Average MET after submaximal exercise for each subject group.Note: The error bars represent standard deviation.Abbreviation: MET, metabolic equivalent.

Mentions: Figure 2 shows the change in while inhaling each gas mixture for each group. The average values indicate that the healthy and unchallenged asthmatics have near normal values (ie, 1 at rest). The COPD participants have elevated , indicating they might have difficulty doing everyday activities since this ratio is a measure for exercise capacity.33 It is important to point out that for the COPD participants the average response to He/O2 at rest is negative in terms of metabolic cost in that the increased. In Figure 3, the average MET values for submaximal exercise are shown; now note that for all groups there is some benefit due to He/O2. The work rate of the exercise ranges from the equivalent of very heavy housework for the healthy participants to very light housework for the severe participants (Table 2).32


Effects of a helium/oxygen mixture on individuals' lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases.

Häussermann S, Schulze A, Katz IM, Martin AR, Herpich C, Hunger T, Texereau J - Int J Chron Obstruct Pulmon Dis (2015)

Average MET after submaximal exercise for each subject group.Note: The error bars represent standard deviation.Abbreviation: MET, metabolic equivalent.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590345&req=5

f3-copd-10-1987: Average MET after submaximal exercise for each subject group.Note: The error bars represent standard deviation.Abbreviation: MET, metabolic equivalent.
Mentions: Figure 2 shows the change in while inhaling each gas mixture for each group. The average values indicate that the healthy and unchallenged asthmatics have near normal values (ie, 1 at rest). The COPD participants have elevated , indicating they might have difficulty doing everyday activities since this ratio is a measure for exercise capacity.33 It is important to point out that for the COPD participants the average response to He/O2 at rest is negative in terms of metabolic cost in that the increased. In Figure 3, the average MET values for submaximal exercise are shown; now note that for all groups there is some benefit due to He/O2. The work rate of the exercise ranges from the equivalent of very heavy housework for the healthy participants to very light housework for the severe participants (Table 2).32

Bottom Line: For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate.However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Inamed GmbH, Gauting, Germany.

ABSTRACT

Background: Helium/oxygen therapies have been studied as a means to reduce the symptoms of obstructive lung diseases with inconclusive results in clinical trials. To better understand this variability in results, an exploratory physiological study was performed comparing the effects of helium/oxygen mixture (78%/22%) to that of medical air.

Methods: The gas mixtures were administered to healthy, asthmatic, and chronic obstructive pulmonary disease (COPD) participants, both moderate and severe (6 participants in each disease group, a total of 30); at rest and during submaximal cycling exercise with equivalent work rates. Measurements of ventilatory parameters, forced spirometry, and ergospirometry were obtained.

Results: There was no statistical difference in ventilatory and cardiac responses to breathing helium/oxygen during submaximal exercise. For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate. However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.

Conclusion: The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

No MeSH data available.


Related in: MedlinePlus