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Evaluation of percutaneous permeation of repellent DEET and sunscreen oxybenzone from emulsion-based formulations in artificial membrane and human skin.

Wang T, Miller D, Burczynski F, Gu X - Acta Pharm Sin B (2014)

Bottom Line: The purpose of this study was to investigate the effects of emulsion type, addition of thickening agent and droplet size in three emulsion-based lotions on percutaneous permeation of DEET and oxybenzone using in vitro diffusion experiments, in order to minimize overall systemic permeation of the substances.Formulation B (oil-in-water emulsion with thickening agent xanthan gum) significantly decreased the size of oil droplet containing DEET (16%), but no effect on oil droplets containing oxybenzone.Adding xanthan gum also increased overall permeation of DEET and oxybenzone (21% and 150%) when compared to Formulation A; presence of both ingredients in Formulation B further increased their permeation (36% and 23%) in comparison to its single counterparts.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

ABSTRACT
Insect repellent DEET and sunscreen ingredient oxybenzone play an essential role in minimizing vector-borne diseases and skin cancers. The purpose of this study was to investigate the effects of emulsion type, addition of thickening agent and droplet size in three emulsion-based lotions on percutaneous permeation of DEET and oxybenzone using in vitro diffusion experiments, in order to minimize overall systemic permeation of the substances. Formulation C (water-in-oil emulsion) significantly increased overall permeation of DEET through human skin (56%) compared to Formulation A (oil-in-water emulsion). Formulation B (oil-in-water emulsion with thickening agent xanthan gum) significantly decreased the size of oil droplet containing DEET (16%), but no effect on oil droplets containing oxybenzone. Adding xanthan gum also increased overall permeation of DEET and oxybenzone (21% and 150%) when compared to Formulation A; presence of both ingredients in Formulation B further increased their permeation (36% and 23%) in comparison to its single counterparts. Overall permeation of oxybenzone through LDPE was significantly higher by 26%-628% than that through human skin; overall permeation of DEET through human skin was significantly higher by 64%-338% than that through LDPE.

No MeSH data available.


Related in: MedlinePlus

Overall OBZ permeation percentage from three formulations through LDPE (n=4, Mean±SEM, P≤0.05). 1: Significant difference between FA and FB/FC (membrane+receptor fluid); 1′: Significant difference between single preparations and combined preparations (membrane+receptor fluid); 2: Significant difference between FA and FB/FC (membrane only); 2′: Significant difference between single preparations and combined preparations (membrane only); 3: Significant difference between FA and FB/FC (receptor fluid only); 3′: Significant different between single preparations and combined preparations (receptor fluid only).
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f0025: Overall OBZ permeation percentage from three formulations through LDPE (n=4, Mean±SEM, P≤0.05). 1: Significant difference between FA and FB/FC (membrane+receptor fluid); 1′: Significant difference between single preparations and combined preparations (membrane+receptor fluid); 2: Significant difference between FA and FB/FC (membrane only); 2′: Significant difference between single preparations and combined preparations (membrane only); 3: Significant difference between FA and FB/FC (receptor fluid only); 3′: Significant different between single preparations and combined preparations (receptor fluid only).


Evaluation of percutaneous permeation of repellent DEET and sunscreen oxybenzone from emulsion-based formulations in artificial membrane and human skin.

Wang T, Miller D, Burczynski F, Gu X - Acta Pharm Sin B (2014)

Overall OBZ permeation percentage from three formulations through LDPE (n=4, Mean±SEM, P≤0.05). 1: Significant difference between FA and FB/FC (membrane+receptor fluid); 1′: Significant difference between single preparations and combined preparations (membrane+receptor fluid); 2: Significant difference between FA and FB/FC (membrane only); 2′: Significant difference between single preparations and combined preparations (membrane only); 3: Significant difference between FA and FB/FC (receptor fluid only); 3′: Significant different between single preparations and combined preparations (receptor fluid only).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590294&req=5

f0025: Overall OBZ permeation percentage from three formulations through LDPE (n=4, Mean±SEM, P≤0.05). 1: Significant difference between FA and FB/FC (membrane+receptor fluid); 1′: Significant difference between single preparations and combined preparations (membrane+receptor fluid); 2: Significant difference between FA and FB/FC (membrane only); 2′: Significant difference between single preparations and combined preparations (membrane only); 3: Significant difference between FA and FB/FC (receptor fluid only); 3′: Significant different between single preparations and combined preparations (receptor fluid only).
Bottom Line: The purpose of this study was to investigate the effects of emulsion type, addition of thickening agent and droplet size in three emulsion-based lotions on percutaneous permeation of DEET and oxybenzone using in vitro diffusion experiments, in order to minimize overall systemic permeation of the substances.Formulation B (oil-in-water emulsion with thickening agent xanthan gum) significantly decreased the size of oil droplet containing DEET (16%), but no effect on oil droplets containing oxybenzone.Adding xanthan gum also increased overall permeation of DEET and oxybenzone (21% and 150%) when compared to Formulation A; presence of both ingredients in Formulation B further increased their permeation (36% and 23%) in comparison to its single counterparts.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

ABSTRACT
Insect repellent DEET and sunscreen ingredient oxybenzone play an essential role in minimizing vector-borne diseases and skin cancers. The purpose of this study was to investigate the effects of emulsion type, addition of thickening agent and droplet size in three emulsion-based lotions on percutaneous permeation of DEET and oxybenzone using in vitro diffusion experiments, in order to minimize overall systemic permeation of the substances. Formulation C (water-in-oil emulsion) significantly increased overall permeation of DEET through human skin (56%) compared to Formulation A (oil-in-water emulsion). Formulation B (oil-in-water emulsion with thickening agent xanthan gum) significantly decreased the size of oil droplet containing DEET (16%), but no effect on oil droplets containing oxybenzone. Adding xanthan gum also increased overall permeation of DEET and oxybenzone (21% and 150%) when compared to Formulation A; presence of both ingredients in Formulation B further increased their permeation (36% and 23%) in comparison to its single counterparts. Overall permeation of oxybenzone through LDPE was significantly higher by 26%-628% than that through human skin; overall permeation of DEET through human skin was significantly higher by 64%-338% than that through LDPE.

No MeSH data available.


Related in: MedlinePlus