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Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial.

Alshweki A, Muñuzuri AP, Baña AM, de Castro MJ, Andrade F, Aldamiz-Echevarría L, de Pipaón MS, Fraga JM, Couce ML - Nutr J (2015)

Bottom Line: The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7).There were no significant differences in growth or evoked potentials between the two formula groups.Very preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1.

View Article: PubMed Central - PubMed

Affiliation: Neonatology Unit, Department of Paediatrics, University Clinical Hospital of Santiago de Compostela. IDIS, CIBERER, Travesia Choupana, 15706, Santiago de Compostela, Spain. drayham@live.com.

ABSTRACT

Background & aims: Nutritional supplementation with polyunsaturated fatty acids is important in preterm infants neurodevelopment, but it is not known if the omega-6/omega-3 ratio affects this process. This study was designed to determine the effects of a balanced contribution of arachidonic acid in very preterm newborns fed with formula milk.

Methods: This was a randomized trial, in which newborns <1500 g and/or <32 weeks gestational age were assigned to one of two groups, based on the milk formula they would receive during the first year of life. Initially, 60 newborns entered the study, but ultimately, group A was composed of 24 newborns, who were given formula milk with an ω-6/ω-3 ratio of 2/1, and Group B was composed of 21 newborns, given formula milk with an ω-6/ω-3 ratio of 1/1. The infants were followed up for two years: growth, visual-evoked potentials, brainstem auditory-evoked potentials, and plasma fatty acids were periodically measured, and psychomotor development was assessed using the Brunet Lézine scale at 24 months corrected age. A control group, for comparison of Brunet Lézine score, was made up of 25 newborns from the SEN1500 project, who were fed exclusively with breast milk.

Results: At 12 months, arachidonic acid values were significantly higher in group A than in group B (6.95 ± 1.55% vs. 4.55 ± 0.78%), as were polyunsaturated fatty acids (41.02 ± 2.09% vs. 38.08 ± 2.32%) achieved a higher average. Group A achieved a higher average Brunet Lézine score at 24 months than group B (99.9 ± 9 vs. 90.8 ± 11, p =0.028). The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7). There were no significant differences in growth or evoked potentials between the two formula groups.

Conclusions: Very preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1. Therefore, formula milk with an arachidonic acid quantity double that of docosahexaenoic acid should be considered for feeding very preterm infants.

Trial registration: ClinicalTrials.gov Identifier NCT02503020.

No MeSH data available.


Related in: MedlinePlus

Dietary intervention and follow-up of children during the first two years of life. CA, corerected age; IVH, intraventricular hemorrhage
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Related In: Results  -  Collection

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Fig1: Dietary intervention and follow-up of children during the first two years of life. CA, corerected age; IVH, intraventricular hemorrhage

Mentions: Sixty-one infants were recruited (Fig. 1), and 60 infants were randomly assigned to one of the two study formulas. Forty-five infants were followed up until 24 months of age.Fig. 1


Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial.

Alshweki A, Muñuzuri AP, Baña AM, de Castro MJ, Andrade F, Aldamiz-Echevarría L, de Pipaón MS, Fraga JM, Couce ML - Nutr J (2015)

Dietary intervention and follow-up of children during the first two years of life. CA, corerected age; IVH, intraventricular hemorrhage
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4590272&req=5

Fig1: Dietary intervention and follow-up of children during the first two years of life. CA, corerected age; IVH, intraventricular hemorrhage
Mentions: Sixty-one infants were recruited (Fig. 1), and 60 infants were randomly assigned to one of the two study formulas. Forty-five infants were followed up until 24 months of age.Fig. 1

Bottom Line: The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7).There were no significant differences in growth or evoked potentials between the two formula groups.Very preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1.

View Article: PubMed Central - PubMed

Affiliation: Neonatology Unit, Department of Paediatrics, University Clinical Hospital of Santiago de Compostela. IDIS, CIBERER, Travesia Choupana, 15706, Santiago de Compostela, Spain. drayham@live.com.

ABSTRACT

Background & aims: Nutritional supplementation with polyunsaturated fatty acids is important in preterm infants neurodevelopment, but it is not known if the omega-6/omega-3 ratio affects this process. This study was designed to determine the effects of a balanced contribution of arachidonic acid in very preterm newborns fed with formula milk.

Methods: This was a randomized trial, in which newborns <1500 g and/or <32 weeks gestational age were assigned to one of two groups, based on the milk formula they would receive during the first year of life. Initially, 60 newborns entered the study, but ultimately, group A was composed of 24 newborns, who were given formula milk with an ω-6/ω-3 ratio of 2/1, and Group B was composed of 21 newborns, given formula milk with an ω-6/ω-3 ratio of 1/1. The infants were followed up for two years: growth, visual-evoked potentials, brainstem auditory-evoked potentials, and plasma fatty acids were periodically measured, and psychomotor development was assessed using the Brunet Lézine scale at 24 months corrected age. A control group, for comparison of Brunet Lézine score, was made up of 25 newborns from the SEN1500 project, who were fed exclusively with breast milk.

Results: At 12 months, arachidonic acid values were significantly higher in group A than in group B (6.95 ± 1.55% vs. 4.55 ± 0.78%), as were polyunsaturated fatty acids (41.02 ± 2.09% vs. 38.08 ± 2.32%) achieved a higher average. Group A achieved a higher average Brunet Lézine score at 24 months than group B (99.9 ± 9 vs. 90.8 ± 11, p =0.028). The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7). There were no significant differences in growth or evoked potentials between the two formula groups.

Conclusions: Very preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1. Therefore, formula milk with an arachidonic acid quantity double that of docosahexaenoic acid should be considered for feeding very preterm infants.

Trial registration: ClinicalTrials.gov Identifier NCT02503020.

No MeSH data available.


Related in: MedlinePlus