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The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study.

Ant A, Karamert R, Kulduk G, Ekinci Ö, Tutar H, Göksu N - Surg Neurol Int (2015)

Bottom Line: Statistical significance of P < 0.05 was taken as criterion.No morphological changes were observed on vascular and neural structures in the study groups in both concentrations, compared to the control group.On a morphological basis, a single application of MESNA does not cause any morphological changes that indicate a toxicity in neural and neurovascular structures.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Afsin State Hospital, Kahramanmaras, Turkey.

ABSTRACT

Background: Sodium-2-mercaptoethanesulfonate (MESNA) is a protective agent that is also used as "a chemical dissector" in various surgical fields. The aim of this study is to evaluate the toxic effects of MESNA on neural and neurovascular structures based on a morphological analysis and examine its safety in neurotological applications.

Methods: Three groups of guinea pigs were used as subjects. MESNA solution (50 and 100%) and saline solution were applied to the subarachnoid space over the brain tissue via a middle fossa approach of study and control groups, respectively. Effects of MESNA were assessed by means of light microscope. McNemar Chi-square test was used to evaluate the histopathological findings. Statistical significance of P < 0.05 was taken as criterion.

Results: No morphological changes were observed on vascular and neural structures in the study groups in both concentrations, compared to the control group.

Conclusions: On a morphological basis, a single application of MESNA does not cause any morphological changes that indicate a toxicity in neural and neurovascular structures.

No MeSH data available.


Related in: MedlinePlus

Surgical procedure; craniotomy above the zygomatic root, dura flap with the Penrose drain
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Figure 3: Surgical procedure; craniotomy above the zygomatic root, dura flap with the Penrose drain

Mentions: Surgery was performed under a surgical microscope and sterile conditions. A supraauricular 2 cm incision was performed on the left side for all subjects [Figure 1]. Zygomatic root was exposed and a 1 cm diameter circle craniotomy was made 0.5 cm above the root with a diamond burr [Figures 2 and 3].


The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study.

Ant A, Karamert R, Kulduk G, Ekinci Ö, Tutar H, Göksu N - Surg Neurol Int (2015)

Surgical procedure; craniotomy above the zygomatic root, dura flap with the Penrose drain
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4590178&req=5

Figure 3: Surgical procedure; craniotomy above the zygomatic root, dura flap with the Penrose drain
Mentions: Surgery was performed under a surgical microscope and sterile conditions. A supraauricular 2 cm incision was performed on the left side for all subjects [Figure 1]. Zygomatic root was exposed and a 1 cm diameter circle craniotomy was made 0.5 cm above the root with a diamond burr [Figures 2 and 3].

Bottom Line: Statistical significance of P < 0.05 was taken as criterion.No morphological changes were observed on vascular and neural structures in the study groups in both concentrations, compared to the control group.On a morphological basis, a single application of MESNA does not cause any morphological changes that indicate a toxicity in neural and neurovascular structures.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Afsin State Hospital, Kahramanmaras, Turkey.

ABSTRACT

Background: Sodium-2-mercaptoethanesulfonate (MESNA) is a protective agent that is also used as "a chemical dissector" in various surgical fields. The aim of this study is to evaluate the toxic effects of MESNA on neural and neurovascular structures based on a morphological analysis and examine its safety in neurotological applications.

Methods: Three groups of guinea pigs were used as subjects. MESNA solution (50 and 100%) and saline solution were applied to the subarachnoid space over the brain tissue via a middle fossa approach of study and control groups, respectively. Effects of MESNA were assessed by means of light microscope. McNemar Chi-square test was used to evaluate the histopathological findings. Statistical significance of P < 0.05 was taken as criterion.

Results: No morphological changes were observed on vascular and neural structures in the study groups in both concentrations, compared to the control group.

Conclusions: On a morphological basis, a single application of MESNA does not cause any morphological changes that indicate a toxicity in neural and neurovascular structures.

No MeSH data available.


Related in: MedlinePlus