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The influence of Streptococcus pneumoniae nasopharyngeal colonization on the clinical outcome of the respiratory tract infections in preschool children.

Petraitiene S, Alasevicius T, Staceviciene I, Vaiciuniene D, Kacergius T, Usonis V - BMC Infect. Dis. (2015)

Bottom Line: Clinical signs and symptoms were not associated with SPn colonization.Children attending day care centres had significantly higher prevalence of SPn colonization (270 of 367, 44.4 % vs 338 of 533, 33.1 %, p = 0.001).It is also associated with and may be responsible for higher frequencies of bronchitis, pneumonia, acute otitis media, sinusitis and the need of antimicrobial treatment.

View Article: PubMed Central - PubMed

Affiliation: Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania. siga.petraitiene@gmail.com.

ABSTRACT

Background: Streptococcus pneumoniae (SPn) is an important pathogen causing a variety of clinical manifestations. The effects of SPn nasopharyngeal colonization on respiratory tract infections are poorly studied. We evaluated the association of SPn colonization with features of respiratory tract infections.

Methods: Children under the age of 6 years who visited a primary care physician because of respiratory tract infections were enrolled in the study. History was taken, children were clinically assessed by the physician, and nasopharyngeal swabs were obtained and cultured for SPn. Positive samples were serotyped. Associations of SPn colonization with clinical signs and symptoms, recovery duration, absence from day care centre, frequencies of specific diagnoses, and treatment with antimicrobials were evaluated.

Results: In total 900 children were enrolled. The prevalence of SPn colonization was 40.8 % (n = 367). There were minor differences between male and female subjects (199 of 492, 40.4 % vs 168 of 408, 41.2 %, p = 0.825). Children with and without siblings had similar colonization rates (145 of 334, 43.4 % vs 219 of 562, 39.0 %, p = 0.187). Clinical signs and symptoms were not associated with SPn colonization. Children colonized with SPn had longer recovery duration compared to non-colonized children (114 of 367, 31.1 % vs 98 of 533, 18.4 %, p < 0.001) and were longer absent from day care (270 of 608, 44.4 % vs 94 of 284, 33.1 %, p = 0.001). Pneumonia, sinusitis, and acute otitis media were more frequently diagnosed in children colonized with SPn. Children attending day care centres had significantly higher prevalence of SPn colonization (270 of 367, 44.4 % vs 338 of 533, 33.1 %, p = 0.001). Children with pneumonia, sinusitis and acute otitis media were more frequently treated with antimicrobials than children with other diagnoses.

Conclusions: SPn nasopharyngeal colonization has a negative impact on the course of respiratory tract infection, likely because of SPn being the cause of the disease or a complicating factor. It is also associated with and may be responsible for higher frequencies of bronchitis, pneumonia, acute otitis media, sinusitis and the need of antimicrobial treatment.

No MeSH data available.


Related in: MedlinePlus

Use of antimicrobials based on Streptococcus pneumoniae serotype/serogroup. Only serotypes with at least 10 cases are displayed. Antimicrobial use (used vs not used) for each serotype/serogroup compared with SPn-negative group (chi-squared test). 15–serogroup 15. 23–non-23F serotypes
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Fig2: Use of antimicrobials based on Streptococcus pneumoniae serotype/serogroup. Only serotypes with at least 10 cases are displayed. Antimicrobial use (used vs not used) for each serotype/serogroup compared with SPn-negative group (chi-squared test). 15–serogroup 15. 23–non-23F serotypes

Mentions: Antimicrobials were similarly prescribed to female and male participants (168 cases, 42.6 % and 188 cases, 40.4 % respectively, p = 0.512). Children with pneumonia, sinusitis and AOM were more frequently treated with antimicrobials than children with other diagnoses. The rates of antimicrobial prescription for specific diagnoses are presented in Table 3 and antimicrobial use per specific serotypes cases is shown in Fig. 2.Fig. 2


The influence of Streptococcus pneumoniae nasopharyngeal colonization on the clinical outcome of the respiratory tract infections in preschool children.

Petraitiene S, Alasevicius T, Staceviciene I, Vaiciuniene D, Kacergius T, Usonis V - BMC Infect. Dis. (2015)

Use of antimicrobials based on Streptococcus pneumoniae serotype/serogroup. Only serotypes with at least 10 cases are displayed. Antimicrobial use (used vs not used) for each serotype/serogroup compared with SPn-negative group (chi-squared test). 15–serogroup 15. 23–non-23F serotypes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4589981&req=5

Fig2: Use of antimicrobials based on Streptococcus pneumoniae serotype/serogroup. Only serotypes with at least 10 cases are displayed. Antimicrobial use (used vs not used) for each serotype/serogroup compared with SPn-negative group (chi-squared test). 15–serogroup 15. 23–non-23F serotypes
Mentions: Antimicrobials were similarly prescribed to female and male participants (168 cases, 42.6 % and 188 cases, 40.4 % respectively, p = 0.512). Children with pneumonia, sinusitis and AOM were more frequently treated with antimicrobials than children with other diagnoses. The rates of antimicrobial prescription for specific diagnoses are presented in Table 3 and antimicrobial use per specific serotypes cases is shown in Fig. 2.Fig. 2

Bottom Line: Clinical signs and symptoms were not associated with SPn colonization.Children attending day care centres had significantly higher prevalence of SPn colonization (270 of 367, 44.4 % vs 338 of 533, 33.1 %, p = 0.001).It is also associated with and may be responsible for higher frequencies of bronchitis, pneumonia, acute otitis media, sinusitis and the need of antimicrobial treatment.

View Article: PubMed Central - PubMed

Affiliation: Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania. siga.petraitiene@gmail.com.

ABSTRACT

Background: Streptococcus pneumoniae (SPn) is an important pathogen causing a variety of clinical manifestations. The effects of SPn nasopharyngeal colonization on respiratory tract infections are poorly studied. We evaluated the association of SPn colonization with features of respiratory tract infections.

Methods: Children under the age of 6 years who visited a primary care physician because of respiratory tract infections were enrolled in the study. History was taken, children were clinically assessed by the physician, and nasopharyngeal swabs were obtained and cultured for SPn. Positive samples were serotyped. Associations of SPn colonization with clinical signs and symptoms, recovery duration, absence from day care centre, frequencies of specific diagnoses, and treatment with antimicrobials were evaluated.

Results: In total 900 children were enrolled. The prevalence of SPn colonization was 40.8 % (n = 367). There were minor differences between male and female subjects (199 of 492, 40.4 % vs 168 of 408, 41.2 %, p = 0.825). Children with and without siblings had similar colonization rates (145 of 334, 43.4 % vs 219 of 562, 39.0 %, p = 0.187). Clinical signs and symptoms were not associated with SPn colonization. Children colonized with SPn had longer recovery duration compared to non-colonized children (114 of 367, 31.1 % vs 98 of 533, 18.4 %, p < 0.001) and were longer absent from day care (270 of 608, 44.4 % vs 94 of 284, 33.1 %, p = 0.001). Pneumonia, sinusitis, and acute otitis media were more frequently diagnosed in children colonized with SPn. Children attending day care centres had significantly higher prevalence of SPn colonization (270 of 367, 44.4 % vs 338 of 533, 33.1 %, p = 0.001). Children with pneumonia, sinusitis and acute otitis media were more frequently treated with antimicrobials than children with other diagnoses.

Conclusions: SPn nasopharyngeal colonization has a negative impact on the course of respiratory tract infection, likely because of SPn being the cause of the disease or a complicating factor. It is also associated with and may be responsible for higher frequencies of bronchitis, pneumonia, acute otitis media, sinusitis and the need of antimicrobial treatment.

No MeSH data available.


Related in: MedlinePlus