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Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis.

Dolatkhah R, Somi MH, Kermani IA, Ghojazadeh M, Jafarabadi MA, Farassati F, Dastgiri S - BMC Public Health (2015)

Bottom Line: For accuracy studies, we used estimated rates for males and females with 95 % confidence intervals.Age-standardized incidence rates were obtained based on the random effects model and were 8.16 (95 % CI: 6.64 to 9.68) and 6.17 (95 % CI: 5.01 to 7.32) for males and females, respectively.The random crude rates were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females.

View Article: PubMed Central - PubMed

Affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, 51666114731, Tabriz, Iran. royadolatkhah@yahoo.com.

ABSTRACT

Background: Colorectal cancer is the third most common cancer in Iran. The increasing trend of colorectal cancer incidence in Iran and the close relationship with the geographical location are the underlying reasons for this study.

Data source: Eleven databases, including MEDLINE, EMBASE, SCOPUS, and four other databases, for articles in Persian were searched from April 2014 to October 2014. Additional data were obtained from an online survey of the Central Library of Tabriz Faculty of Medicine.

Study eligibility criteria: In this systematic review and meta-analysis, we included studies reporting different measures of incidence, age-standardized incidence rates, and crude incidence rates. All rates (per 100,000 person-years) were standardized to the world standard population.

Study appraisal and synthesis methods: A preliminary review of the title and abstracts of these articles was used to exclude any that were clearly irrelevant. The full text review determined whether the article was relevant to our topic. All the potentially relevant manuscripts were reviewed by two other investigators (S.D., M.G.). A total of 39 studies (10 Persian and 29 English articles) from different provinces and diverse areas of Iran, were analyzed in this study using comprehensive meta-analysis software. For accuracy studies, we used estimated rates for males and females with 95 % confidence intervals.

Results: Age-standardized incidence rates were obtained based on the random effects model and were 8.16 (95 % CI: 6.64 to 9.68) and 6.17 (95 % CI: 5.01 to 7.32) for males and females, respectively. The random crude rates were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females.

Conclusions: Colorectal cancer incidence rates rise due to individual and environmental risk factors as well as improvement in the registry system and increase in access to health services. A more executed organized and structured system for collecting cancer data, in all cities and rural areas of the country, is an essential priority.

No MeSH data available.


Related in: MedlinePlus

Forest Plot of random-effect meta-analysis for crude incidence rates in males in Iran, 95 % CI, weights are from random effects analysis
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Fig4: Forest Plot of random-effect meta-analysis for crude incidence rates in males in Iran, 95 % CI, weights are from random effects analysis

Mentions: The crude incidence rates (CR) of colorectal cancer obtained based on the random model were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females. The Cochran’s test results indicate for a moderate heterogeneity of review in both males (Q = 44.04, df = 21, I2 = 52.32, P = 0.004) and females (Q = 27.69, df = 21, I2 = 24.15, P = 0.15) (Figs. 4 and 5).Fig. 4


Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis.

Dolatkhah R, Somi MH, Kermani IA, Ghojazadeh M, Jafarabadi MA, Farassati F, Dastgiri S - BMC Public Health (2015)

Forest Plot of random-effect meta-analysis for crude incidence rates in males in Iran, 95 % CI, weights are from random effects analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4589975&req=5

Fig4: Forest Plot of random-effect meta-analysis for crude incidence rates in males in Iran, 95 % CI, weights are from random effects analysis
Mentions: The crude incidence rates (CR) of colorectal cancer obtained based on the random model were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females. The Cochran’s test results indicate for a moderate heterogeneity of review in both males (Q = 44.04, df = 21, I2 = 52.32, P = 0.004) and females (Q = 27.69, df = 21, I2 = 24.15, P = 0.15) (Figs. 4 and 5).Fig. 4

Bottom Line: For accuracy studies, we used estimated rates for males and females with 95 % confidence intervals.Age-standardized incidence rates were obtained based on the random effects model and were 8.16 (95 % CI: 6.64 to 9.68) and 6.17 (95 % CI: 5.01 to 7.32) for males and females, respectively.The random crude rates were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females.

View Article: PubMed Central - PubMed

Affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, 51666114731, Tabriz, Iran. royadolatkhah@yahoo.com.

ABSTRACT

Background: Colorectal cancer is the third most common cancer in Iran. The increasing trend of colorectal cancer incidence in Iran and the close relationship with the geographical location are the underlying reasons for this study.

Data source: Eleven databases, including MEDLINE, EMBASE, SCOPUS, and four other databases, for articles in Persian were searched from April 2014 to October 2014. Additional data were obtained from an online survey of the Central Library of Tabriz Faculty of Medicine.

Study eligibility criteria: In this systematic review and meta-analysis, we included studies reporting different measures of incidence, age-standardized incidence rates, and crude incidence rates. All rates (per 100,000 person-years) were standardized to the world standard population.

Study appraisal and synthesis methods: A preliminary review of the title and abstracts of these articles was used to exclude any that were clearly irrelevant. The full text review determined whether the article was relevant to our topic. All the potentially relevant manuscripts were reviewed by two other investigators (S.D., M.G.). A total of 39 studies (10 Persian and 29 English articles) from different provinces and diverse areas of Iran, were analyzed in this study using comprehensive meta-analysis software. For accuracy studies, we used estimated rates for males and females with 95 % confidence intervals.

Results: Age-standardized incidence rates were obtained based on the random effects model and were 8.16 (95 % CI: 6.64 to 9.68) and 6.17 (95 % CI: 5.01 to 7.32) for males and females, respectively. The random crude rates were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females.

Conclusions: Colorectal cancer incidence rates rise due to individual and environmental risk factors as well as improvement in the registry system and increase in access to health services. A more executed organized and structured system for collecting cancer data, in all cities and rural areas of the country, is an essential priority.

No MeSH data available.


Related in: MedlinePlus