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Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells.

Huang C, Chen W, Wang X, Zhao J, Li Q, Fu Z - Evid Based Complement Alternat Med (2015)

Bottom Line: Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion.Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells.Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

ABSTRACT
Esophageal carcinoma is a major public health problem worldwide and one of the most aggressively malignant neoplasms. Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion. Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT. The aim of our study was to evaluate the significance of Cripto-1 which plays a role in EMT and its metastasis in esophageal carcinoma. Data of this study suggest that Cripto-1 overexpression is connected with the tumorigenesis and progression of esophageal carcinoma; shRNA might be feasible for the inhibition of the invasion and metastasis of esophageal carcinoma.

No MeSH data available.


Related in: MedlinePlus

N-cadherin expression in ESCC tumor samples. (a) Phase I, (b) phase II, (c) phase III, (d) phase IV, and (e) healthy control tissue. Arrow indicates N-cad+ cell. ×400 magnification.
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fig3: N-cadherin expression in ESCC tumor samples. (a) Phase I, (b) phase II, (c) phase III, (d) phase IV, and (e) healthy control tissue. Arrow indicates N-cad+ cell. ×400 magnification.

Mentions: Immunohistochemistry showed that CR-1, E-cad, and N-cad expression mainly localized in the ESCC cell membrane and Vim expression mainly localized to the ESCC cytoplasm, while normal cells around the tumor margin were weakly positive or negative (Figures 1–4).


Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells.

Huang C, Chen W, Wang X, Zhao J, Li Q, Fu Z - Evid Based Complement Alternat Med (2015)

N-cadherin expression in ESCC tumor samples. (a) Phase I, (b) phase II, (c) phase III, (d) phase IV, and (e) healthy control tissue. Arrow indicates N-cad+ cell. ×400 magnification.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4589627&req=5

fig3: N-cadherin expression in ESCC tumor samples. (a) Phase I, (b) phase II, (c) phase III, (d) phase IV, and (e) healthy control tissue. Arrow indicates N-cad+ cell. ×400 magnification.
Mentions: Immunohistochemistry showed that CR-1, E-cad, and N-cad expression mainly localized in the ESCC cell membrane and Vim expression mainly localized to the ESCC cytoplasm, while normal cells around the tumor margin were weakly positive or negative (Figures 1–4).

Bottom Line: Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion.Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells.Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

ABSTRACT
Esophageal carcinoma is a major public health problem worldwide and one of the most aggressively malignant neoplasms. Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion. Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT. The aim of our study was to evaluate the significance of Cripto-1 which plays a role in EMT and its metastasis in esophageal carcinoma. Data of this study suggest that Cripto-1 overexpression is connected with the tumorigenesis and progression of esophageal carcinoma; shRNA might be feasible for the inhibition of the invasion and metastasis of esophageal carcinoma.

No MeSH data available.


Related in: MedlinePlus