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Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans.

Wang J, Hang T, Cheng XM, Li DM, Zhang QG, Wang LJ, Peng YP, Gong JB - Biomed Res Int (2015)

Bottom Line: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05).When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05).The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.

ABSTRACT

Objective: To investigate the correlation of CTRP9 with coronary atherosclerosis.

Methods: Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).

Results: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05). Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C (P < 0.05) in CAD patients. After adjustment of APN, CTRP9 was still related to the above parameters. Serum CTRP9 was a protective factor of CAD (P < 0.05). When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05). The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).

Conclusions: Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD.

No MeSH data available.


Related in: MedlinePlus

mRNA expressions of leptin and CTRP9 in the EAT. CTRP9: C1q/TNF-Related Protein-9; non-CAD: noncoronary artery disease; CAD: coronary arterial disease; EAT: epicardial adipose tissue volume; ∗P < 0.05.
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Related In: Results  -  Collection


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fig1: mRNA expressions of leptin and CTRP9 in the EAT. CTRP9: C1q/TNF-Related Protein-9; non-CAD: noncoronary artery disease; CAD: coronary arterial disease; EAT: epicardial adipose tissue volume; ∗P < 0.05.

Mentions: EAT was collected during CABG and valve replacement, and inflammatory cytokines were measured. When compared with non-CAD patients, the leptin mRNA expression in the EAT increased markedly (P < 0.05), but CTRP9 mRNA expression in the EAT reduced dramatically (P < 0.05, Figure 1) in CAD patients. Immunohistochemistry for leptin and macrophage marker in the EAT showed that leptin expression and macrophage count in CAD patients were significantly higher than those in non-CAD patients, while the CTRP9 expression reduced markedly in CAD patients (Figure 2).


Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans.

Wang J, Hang T, Cheng XM, Li DM, Zhang QG, Wang LJ, Peng YP, Gong JB - Biomed Res Int (2015)

mRNA expressions of leptin and CTRP9 in the EAT. CTRP9: C1q/TNF-Related Protein-9; non-CAD: noncoronary artery disease; CAD: coronary arterial disease; EAT: epicardial adipose tissue volume; ∗P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4589613&req=5

fig1: mRNA expressions of leptin and CTRP9 in the EAT. CTRP9: C1q/TNF-Related Protein-9; non-CAD: noncoronary artery disease; CAD: coronary arterial disease; EAT: epicardial adipose tissue volume; ∗P < 0.05.
Mentions: EAT was collected during CABG and valve replacement, and inflammatory cytokines were measured. When compared with non-CAD patients, the leptin mRNA expression in the EAT increased markedly (P < 0.05), but CTRP9 mRNA expression in the EAT reduced dramatically (P < 0.05, Figure 1) in CAD patients. Immunohistochemistry for leptin and macrophage marker in the EAT showed that leptin expression and macrophage count in CAD patients were significantly higher than those in non-CAD patients, while the CTRP9 expression reduced markedly in CAD patients (Figure 2).

Bottom Line: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05).When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05).The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.

ABSTRACT

Objective: To investigate the correlation of CTRP9 with coronary atherosclerosis.

Methods: Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).

Results: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05). Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C (P < 0.05) in CAD patients. After adjustment of APN, CTRP9 was still related to the above parameters. Serum CTRP9 was a protective factor of CAD (P < 0.05). When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05). The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).

Conclusions: Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD.

No MeSH data available.


Related in: MedlinePlus