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Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.

Barr HL, Halliday N, Cámara M, Barrett DA, Williams P, Forrester DL, Simms R, Smyth AR, Honeybourne D, Whitehouse JL, Nash EF, Dewar J, Clayton A, Knox AJ, Fogarty AW - Eur. Respir. J. (2015)

Bottom Line: Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability (p<0.01).Following the administration of systemic antibiotics, plasma 2-heptyl-4-hydroxyquinoline (p=0.02) and NHQ concentrations (p<0.01) decreased significantly.In conclusion, quorum sensing signal molecules are detectable in cystic fibrosis patients with pulmonary P. aeruginosa infection and are positively correlated with quantitative measures of P. aeruginosa.NHQ correlates with clinical status and has potential as a novel biomarker for P. aeruginosa infection.

View Article: PubMed Central - PubMed

Affiliation: Division of Respiratory Medicine, Clinical Sciences Building, University of Nottingham, City Hospital Campus, Nottingham, UK helen.barr@nottingham.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) in 29 patients with cystic fibrosis at clinical stability (eight samples before the exacerbation and 21 samples after the exacerbation of interest) compared to the beginning of a pulmonary exacerbation.
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Figure 1: Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) in 29 patients with cystic fibrosis at clinical stability (eight samples before the exacerbation and 21 samples after the exacerbation of interest) compared to the beginning of a pulmonary exacerbation.

Mentions: Data were available from 29 individuals who provided paired data at the beginning of the clinical exacerbation and also during a period of clinical stability. Compared to the period of clinical stability, plasma NHQ was increased at presentation for treatment at the beginning of an exacerbation (p=0.008) (fig. 1), while sputum NQNO, sputum C7-PQS and plasma NQNO were lower at this time (p=0.009, p=0.03 and p=0.003, respectively). There was no difference in quantitative microbiological load of P. aeruginosa measured at clinical stability when compared with the start of the pulmonary exacerbation (median values of 1.2×107 CFU·g−1 and 1.0×107  CFU·g−1 of sputum, respectively).FIGURE 1


Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.

Barr HL, Halliday N, Cámara M, Barrett DA, Williams P, Forrester DL, Simms R, Smyth AR, Honeybourne D, Whitehouse JL, Nash EF, Dewar J, Clayton A, Knox AJ, Fogarty AW - Eur. Respir. J. (2015)

Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) in 29 patients with cystic fibrosis at clinical stability (eight samples before the exacerbation and 21 samples after the exacerbation of interest) compared to the beginning of a pulmonary exacerbation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4589431&req=5

Figure 1: Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) in 29 patients with cystic fibrosis at clinical stability (eight samples before the exacerbation and 21 samples after the exacerbation of interest) compared to the beginning of a pulmonary exacerbation.
Mentions: Data were available from 29 individuals who provided paired data at the beginning of the clinical exacerbation and also during a period of clinical stability. Compared to the period of clinical stability, plasma NHQ was increased at presentation for treatment at the beginning of an exacerbation (p=0.008) (fig. 1), while sputum NQNO, sputum C7-PQS and plasma NQNO were lower at this time (p=0.009, p=0.03 and p=0.003, respectively). There was no difference in quantitative microbiological load of P. aeruginosa measured at clinical stability when compared with the start of the pulmonary exacerbation (median values of 1.2×107 CFU·g−1 and 1.0×107  CFU·g−1 of sputum, respectively).FIGURE 1

Bottom Line: Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability (p<0.01).Following the administration of systemic antibiotics, plasma 2-heptyl-4-hydroxyquinoline (p=0.02) and NHQ concentrations (p<0.01) decreased significantly.In conclusion, quorum sensing signal molecules are detectable in cystic fibrosis patients with pulmonary P. aeruginosa infection and are positively correlated with quantitative measures of P. aeruginosa.NHQ correlates with clinical status and has potential as a novel biomarker for P. aeruginosa infection.

View Article: PubMed Central - PubMed

Affiliation: Division of Respiratory Medicine, Clinical Sciences Building, University of Nottingham, City Hospital Campus, Nottingham, UK helen.barr@nottingham.ac.uk.

No MeSH data available.


Related in: MedlinePlus