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The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis.

Yuan C, Liu X, Liu X, Yang N, Liu Z, Yan S, Shen K, Kong B - PLoS ONE (2015)

Bottom Line: We found a statistically significant difference in the GADD45A (1506T>C) genotype distributions between the case and control groups (TT vs.We observed a statistically significant effect between tumor histology (P = 0.032) and CA125 status (P = 0.021).Carrying the C allele (TC+CC) was associated with an increased risk of positive CA125 (OR = 3.20, 95% CI [1.15-8.71).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China; Gynecologic Oncology Key Laboratory of Shandong Province, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China.

ABSTRACT
GADD45A (growth arrest and DNA damage 45 A) is the first stress-inducible gene identified to be a target of p53. However, no studies to date have assessed variants of the GADD45 gene and their potential relationship to tumor susceptibility. We investigated the association of the GADD45A (1506T>C) polymorphism with ovarian cancer development in 258 ovarian cancer patients and 332 age-matched healthy women as controls using sequence analysis. We found a statistically significant difference in the GADD45A (1506T>C) genotype distributions between the case and control groups (TT vs. TC vs. CC, P = 0.0021) and found that variant 1506T>C was significantly associated with an increased risk of ovarian cancer (P<0.001, OR = 1.71, 95% CI [1.28-2.29]). We observed a statistically significant effect between tumor histology (P = 0.032) and CA125 status (P = 0.021). Carrying the C allele (TC+CC) was associated with an increased risk of positive CA125 (OR = 3.20, 95% CI [1.15-8.71). Carrying the T allele (TT+TC) showed a significant correlation with both higher GADD45A mRNA expression and longer ovarian cancer RFS (relapse-free survival) and OS (overall survival). We are the first group to demonstrate that the GADD45A (1506T>C) polymorphism is associated with ovarian cancer susceptibility and prognosis. These data suggest that GADD45A (1506T>C) is a new tumor susceptibility gene and could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis.

No MeSH data available.


Related in: MedlinePlus

GADD45A genotypes and ovarian cancer prognosis.A, Genotype TT+TC of GADD45A had longer relapse-free survival (P = 0.018). B, Genotype TT+TC of GADD45A had longer overall survival (P = 0.0093).
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pone.0138692.g003: GADD45A genotypes and ovarian cancer prognosis.A, Genotype TT+TC of GADD45A had longer relapse-free survival (P = 0.018). B, Genotype TT+TC of GADD45A had longer overall survival (P = 0.0093).

Mentions: To test the prognostic power of the GADD45A polymorphism in ovarian cancer, we calculated the GADD45A genotype with respect to ovarian relapse-free survival (RFS) and overall survival (OS). As shown in Fig 3, the TT+TC genotype showed significant correlation with both longer ovarian cancer RFS and OS in 151 patients (P = 0.018, P = 0.0093, respectively).


The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis.

Yuan C, Liu X, Liu X, Yang N, Liu Z, Yan S, Shen K, Kong B - PLoS ONE (2015)

GADD45A genotypes and ovarian cancer prognosis.A, Genotype TT+TC of GADD45A had longer relapse-free survival (P = 0.018). B, Genotype TT+TC of GADD45A had longer overall survival (P = 0.0093).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4589388&req=5

pone.0138692.g003: GADD45A genotypes and ovarian cancer prognosis.A, Genotype TT+TC of GADD45A had longer relapse-free survival (P = 0.018). B, Genotype TT+TC of GADD45A had longer overall survival (P = 0.0093).
Mentions: To test the prognostic power of the GADD45A polymorphism in ovarian cancer, we calculated the GADD45A genotype with respect to ovarian relapse-free survival (RFS) and overall survival (OS). As shown in Fig 3, the TT+TC genotype showed significant correlation with both longer ovarian cancer RFS and OS in 151 patients (P = 0.018, P = 0.0093, respectively).

Bottom Line: We found a statistically significant difference in the GADD45A (1506T>C) genotype distributions between the case and control groups (TT vs.We observed a statistically significant effect between tumor histology (P = 0.032) and CA125 status (P = 0.021).Carrying the C allele (TC+CC) was associated with an increased risk of positive CA125 (OR = 3.20, 95% CI [1.15-8.71).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China; Gynecologic Oncology Key Laboratory of Shandong Province, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China.

ABSTRACT
GADD45A (growth arrest and DNA damage 45 A) is the first stress-inducible gene identified to be a target of p53. However, no studies to date have assessed variants of the GADD45 gene and their potential relationship to tumor susceptibility. We investigated the association of the GADD45A (1506T>C) polymorphism with ovarian cancer development in 258 ovarian cancer patients and 332 age-matched healthy women as controls using sequence analysis. We found a statistically significant difference in the GADD45A (1506T>C) genotype distributions between the case and control groups (TT vs. TC vs. CC, P = 0.0021) and found that variant 1506T>C was significantly associated with an increased risk of ovarian cancer (P<0.001, OR = 1.71, 95% CI [1.28-2.29]). We observed a statistically significant effect between tumor histology (P = 0.032) and CA125 status (P = 0.021). Carrying the C allele (TC+CC) was associated with an increased risk of positive CA125 (OR = 3.20, 95% CI [1.15-8.71). Carrying the T allele (TT+TC) showed a significant correlation with both higher GADD45A mRNA expression and longer ovarian cancer RFS (relapse-free survival) and OS (overall survival). We are the first group to demonstrate that the GADD45A (1506T>C) polymorphism is associated with ovarian cancer susceptibility and prognosis. These data suggest that GADD45A (1506T>C) is a new tumor susceptibility gene and could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis.

No MeSH data available.


Related in: MedlinePlus