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High Treatment Retention Rate in HIV-Infected Patients Receiving Antiretroviral Therapy at Two Large HIV Clinics in Hanoi, Vietnam.

Matsumoto S, Tanuma J, Mizushima D, Nguyen NC, Pham TT, Do CD, Nguyen TQ, Nguyen DT, Nguyen HD, Nguyen LT, Nguyen KV, Oka S - PLoS ONE (2015)

Bottom Line: In Vietnam, the reasons for disengagement from clinics and the effect of injection drug use (IDU) on LTFU with unknown outcome (true LTFU) are not well known.True LTFU correlated significantly with low CD4 count and high plasma viral load, but not history of IDU.Imprisonment is a major cause of disengagement from HIV care among patients with a history of IDU.

View Article: PubMed Central - PubMed

Affiliation: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan; Graduate School of Public Health, Teikyo University, Tokyo, Japan.

ABSTRACT

Background: Loss to follow-up (LTFU) is viewed as a major challenge in improving retention in HIV treatment. In Vietnam, the reasons for disengagement from clinics and the effect of injection drug use (IDU) on LTFU with unknown outcome (true LTFU) are not well known.

Methods: Patients receiving antiretroviral therapy (ART) from two HIV clinics in Hanoi were included in this observational study between 2007 and 2012, and followed up every 6 months until the end of 2013. The reasons for disengagement from the clinic, and ART status during imprisonment were investigated in patients with a history of IDU to identify true LTFU. The retention rate at 6-54 months and true LTFU rate were calculated. Cox proportional hazards regression models were performed to identify factors associated with true LTFU.

Results: There were 1,431 patients, with a follow-up time of 4,371 person-years (median 2.49 years). At the end of the follow-up period, 71 (5.0%) patients died, 79 (5.5%) transferred to other clinics, 16 (1.1%) disengaged from the clinics, and the calculated true LTFU was 45 (3.1%), with 12-month ART retention rate of 95.3% for the entire study population. Imprisonment was the most frequent reason for disengagement from the clinics. True LTFU correlated significantly with low CD4 count and high plasma viral load, but not history of IDU.

Conclusion: Imprisonment is a major cause of disengagement from HIV care among patients with a history of IDU.

No MeSH data available.


Related in: MedlinePlus

Retention rate for ART at 6–54 months after study enrollment.The retention rate was calculated by dividing the number of patients who were still alive and on ART at 6–54 months by the total number of patients who had been followed up for 6–54 months, including those who died, those lost to follow-up, and those who disengaged from the clinic. Patients who were transferred to other clinics were excluded. Months; months after enrollment, n: number of the subjects for analysis,—;95%CI.
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pone.0139594.g001: Retention rate for ART at 6–54 months after study enrollment.The retention rate was calculated by dividing the number of patients who were still alive and on ART at 6–54 months by the total number of patients who had been followed up for 6–54 months, including those who died, those lost to follow-up, and those who disengaged from the clinic. Patients who were transferred to other clinics were excluded. Months; months after enrollment, n: number of the subjects for analysis,—;95%CI.

Mentions: Fig 1 shows the retention rate at 6–54 months after study enrollment. The retention rates at 6- and 12-months were relatively high [97.1% (95%CI: 96.1–97.9%, and 95.3% (95%CI: 94.1–96.3%), respectively]. A total of 178 patients had started ART within 3 months before enrollment. The 6- and 12-month retention rates for the latter group were 96.1% (95% CI: 92.1–98.4%) and 93.2% (88.5–96.5%), respectively (data not shown).


High Treatment Retention Rate in HIV-Infected Patients Receiving Antiretroviral Therapy at Two Large HIV Clinics in Hanoi, Vietnam.

Matsumoto S, Tanuma J, Mizushima D, Nguyen NC, Pham TT, Do CD, Nguyen TQ, Nguyen DT, Nguyen HD, Nguyen LT, Nguyen KV, Oka S - PLoS ONE (2015)

Retention rate for ART at 6–54 months after study enrollment.The retention rate was calculated by dividing the number of patients who were still alive and on ART at 6–54 months by the total number of patients who had been followed up for 6–54 months, including those who died, those lost to follow-up, and those who disengaged from the clinic. Patients who were transferred to other clinics were excluded. Months; months after enrollment, n: number of the subjects for analysis,—;95%CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4589350&req=5

pone.0139594.g001: Retention rate for ART at 6–54 months after study enrollment.The retention rate was calculated by dividing the number of patients who were still alive and on ART at 6–54 months by the total number of patients who had been followed up for 6–54 months, including those who died, those lost to follow-up, and those who disengaged from the clinic. Patients who were transferred to other clinics were excluded. Months; months after enrollment, n: number of the subjects for analysis,—;95%CI.
Mentions: Fig 1 shows the retention rate at 6–54 months after study enrollment. The retention rates at 6- and 12-months were relatively high [97.1% (95%CI: 96.1–97.9%, and 95.3% (95%CI: 94.1–96.3%), respectively]. A total of 178 patients had started ART within 3 months before enrollment. The 6- and 12-month retention rates for the latter group were 96.1% (95% CI: 92.1–98.4%) and 93.2% (88.5–96.5%), respectively (data not shown).

Bottom Line: In Vietnam, the reasons for disengagement from clinics and the effect of injection drug use (IDU) on LTFU with unknown outcome (true LTFU) are not well known.True LTFU correlated significantly with low CD4 count and high plasma viral load, but not history of IDU.Imprisonment is a major cause of disengagement from HIV care among patients with a history of IDU.

View Article: PubMed Central - PubMed

Affiliation: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan; Graduate School of Public Health, Teikyo University, Tokyo, Japan.

ABSTRACT

Background: Loss to follow-up (LTFU) is viewed as a major challenge in improving retention in HIV treatment. In Vietnam, the reasons for disengagement from clinics and the effect of injection drug use (IDU) on LTFU with unknown outcome (true LTFU) are not well known.

Methods: Patients receiving antiretroviral therapy (ART) from two HIV clinics in Hanoi were included in this observational study between 2007 and 2012, and followed up every 6 months until the end of 2013. The reasons for disengagement from the clinic, and ART status during imprisonment were investigated in patients with a history of IDU to identify true LTFU. The retention rate at 6-54 months and true LTFU rate were calculated. Cox proportional hazards regression models were performed to identify factors associated with true LTFU.

Results: There were 1,431 patients, with a follow-up time of 4,371 person-years (median 2.49 years). At the end of the follow-up period, 71 (5.0%) patients died, 79 (5.5%) transferred to other clinics, 16 (1.1%) disengaged from the clinics, and the calculated true LTFU was 45 (3.1%), with 12-month ART retention rate of 95.3% for the entire study population. Imprisonment was the most frequent reason for disengagement from the clinics. True LTFU correlated significantly with low CD4 count and high plasma viral load, but not history of IDU.

Conclusion: Imprisonment is a major cause of disengagement from HIV care among patients with a history of IDU.

No MeSH data available.


Related in: MedlinePlus