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Higher Lipoprotein (a) Levels Are Associated with Better Pulmonary Function in Community-Dwelling Older People - Data from the Berlin Aging Study II.

Buchmann N, Kassner U, Norman K, Goldeck D, Eckardt R, Pawelec G, Steinhagen-Thiessen E, Demuth I - PLoS ONE (2015)

Bottom Line: We found a significantly lower forced expiration volume in 1 second (FEV1) in men with low Lp(a) concentrations (t-test).According to the highest adjusted model, men and women with Lp(a) levels below the 20th percentile had 217.3ml and 124.2ml less FEV1 and 239.0ml and 135.2ml less FVC, respectively, compared to participants with higher Lp(a) levels.Our results do not support the hypothesis that higher Lp(a) levels are responsible for the increased CVD risk in people with reduced lung function, at least not in the group of community-dwelling older people studied here.

View Article: PubMed Central - PubMed

Affiliation: Research Group on Geriatrics, Charité -Universitätsmedizin Berlin, Reinickendorfer Str. 61,13347 Berlin, Germany.

ABSTRACT
Reduced pulmonary function and elevated serum cholesterol levels are recognized risk factors for cardiovascular disease. Currently, there is some controversy concerning relationships between cholesterol, LDL-cholesterol, HDL-cholesterol, serum triglycerides and lung function. However, most previous studies compared patients suffering from chronic obstructive pulmonary disease (COPD) with healthy controls, and only a small number examined this relationship in population-based cohorts. Moreover, lipoprotein a [Lp(a)], another lipid parameter independently associated with cardiovascular diseases, appears not to have been addressed at all in studies of lung function at the population level. Here, we determined relationships between lung function and several lipid parameters including Lp(a) in 606 older community-dwelling participants (55.1% women, 68±4 years old) from the Berlin Aging Study II (BASE-II). We found a significantly lower forced expiration volume in 1 second (FEV1) in men with low Lp(a) concentrations (t-test). This finding was further substantiated by linear regression models adjusting for known covariates, showing that these associations are statistically significant in both men and women. According to the highest adjusted model, men and women with Lp(a) levels below the 20th percentile had 217.3ml and 124.2ml less FEV1 and 239.0ml and 135.2ml less FVC, respectively, compared to participants with higher Lp(a) levels. The adjusted models also suggest that the known strong correlation between pro-inflammatory parameters and lung function has only a marginal impact on the Lp(a)-pulmonary function association. Our results do not support the hypothesis that higher Lp(a) levels are responsible for the increased CVD risk in people with reduced lung function, at least not in the group of community-dwelling older people studied here.

No MeSH data available.


Related in: MedlinePlus

Association of pulmonary function and Lp(a) in the Berlin Aging Study II.Measurements of (A) forced expiratory volume in 1 second (FEV1) and (B) forced vital capacity (FVC) are shown separately for men and women to allow the comparison of pulmonary function from participants belonging to Lp(a) quintiles 1 with pulmonary function from participants belonging to Lp(a) quintiles 2–5. Median FEV1 and FVC (black lines) was higher in subjects from Lp(a) quintiles 2–5 in men and women. This difference was statistically significant for FEV1 in men (t-test).
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pone.0139040.g001: Association of pulmonary function and Lp(a) in the Berlin Aging Study II.Measurements of (A) forced expiratory volume in 1 second (FEV1) and (B) forced vital capacity (FVC) are shown separately for men and women to allow the comparison of pulmonary function from participants belonging to Lp(a) quintiles 1 with pulmonary function from participants belonging to Lp(a) quintiles 2–5. Median FEV1 and FVC (black lines) was higher in subjects from Lp(a) quintiles 2–5 in men and women. This difference was statistically significant for FEV1 in men (t-test).

Mentions: Table 3 shows distributions of FEV1, FVC and FEV1/FVC according to Lp(a) quintiles. In men, FEV1 was significantly lower (t-test) in subjects within the Lp(a) quintile 1 compared to quintile 2–5 (Fig 1A). While this distribution was similar in women, the FEV1 difference in the two groups did not reach statistical significance (P = 0.231). FVC did not show statistically significant differences (t-test) in the two groups compared, i.e. Lp(a) quintile 1 vs. Lp(a) quintiles 2–5 (Fig 1B).


Higher Lipoprotein (a) Levels Are Associated with Better Pulmonary Function in Community-Dwelling Older People - Data from the Berlin Aging Study II.

Buchmann N, Kassner U, Norman K, Goldeck D, Eckardt R, Pawelec G, Steinhagen-Thiessen E, Demuth I - PLoS ONE (2015)

Association of pulmonary function and Lp(a) in the Berlin Aging Study II.Measurements of (A) forced expiratory volume in 1 second (FEV1) and (B) forced vital capacity (FVC) are shown separately for men and women to allow the comparison of pulmonary function from participants belonging to Lp(a) quintiles 1 with pulmonary function from participants belonging to Lp(a) quintiles 2–5. Median FEV1 and FVC (black lines) was higher in subjects from Lp(a) quintiles 2–5 in men and women. This difference was statistically significant for FEV1 in men (t-test).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4589348&req=5

pone.0139040.g001: Association of pulmonary function and Lp(a) in the Berlin Aging Study II.Measurements of (A) forced expiratory volume in 1 second (FEV1) and (B) forced vital capacity (FVC) are shown separately for men and women to allow the comparison of pulmonary function from participants belonging to Lp(a) quintiles 1 with pulmonary function from participants belonging to Lp(a) quintiles 2–5. Median FEV1 and FVC (black lines) was higher in subjects from Lp(a) quintiles 2–5 in men and women. This difference was statistically significant for FEV1 in men (t-test).
Mentions: Table 3 shows distributions of FEV1, FVC and FEV1/FVC according to Lp(a) quintiles. In men, FEV1 was significantly lower (t-test) in subjects within the Lp(a) quintile 1 compared to quintile 2–5 (Fig 1A). While this distribution was similar in women, the FEV1 difference in the two groups did not reach statistical significance (P = 0.231). FVC did not show statistically significant differences (t-test) in the two groups compared, i.e. Lp(a) quintile 1 vs. Lp(a) quintiles 2–5 (Fig 1B).

Bottom Line: We found a significantly lower forced expiration volume in 1 second (FEV1) in men with low Lp(a) concentrations (t-test).According to the highest adjusted model, men and women with Lp(a) levels below the 20th percentile had 217.3ml and 124.2ml less FEV1 and 239.0ml and 135.2ml less FVC, respectively, compared to participants with higher Lp(a) levels.Our results do not support the hypothesis that higher Lp(a) levels are responsible for the increased CVD risk in people with reduced lung function, at least not in the group of community-dwelling older people studied here.

View Article: PubMed Central - PubMed

Affiliation: Research Group on Geriatrics, Charité -Universitätsmedizin Berlin, Reinickendorfer Str. 61,13347 Berlin, Germany.

ABSTRACT
Reduced pulmonary function and elevated serum cholesterol levels are recognized risk factors for cardiovascular disease. Currently, there is some controversy concerning relationships between cholesterol, LDL-cholesterol, HDL-cholesterol, serum triglycerides and lung function. However, most previous studies compared patients suffering from chronic obstructive pulmonary disease (COPD) with healthy controls, and only a small number examined this relationship in population-based cohorts. Moreover, lipoprotein a [Lp(a)], another lipid parameter independently associated with cardiovascular diseases, appears not to have been addressed at all in studies of lung function at the population level. Here, we determined relationships between lung function and several lipid parameters including Lp(a) in 606 older community-dwelling participants (55.1% women, 68±4 years old) from the Berlin Aging Study II (BASE-II). We found a significantly lower forced expiration volume in 1 second (FEV1) in men with low Lp(a) concentrations (t-test). This finding was further substantiated by linear regression models adjusting for known covariates, showing that these associations are statistically significant in both men and women. According to the highest adjusted model, men and women with Lp(a) levels below the 20th percentile had 217.3ml and 124.2ml less FEV1 and 239.0ml and 135.2ml less FVC, respectively, compared to participants with higher Lp(a) levels. The adjusted models also suggest that the known strong correlation between pro-inflammatory parameters and lung function has only a marginal impact on the Lp(a)-pulmonary function association. Our results do not support the hypothesis that higher Lp(a) levels are responsible for the increased CVD risk in people with reduced lung function, at least not in the group of community-dwelling older people studied here.

No MeSH data available.


Related in: MedlinePlus