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Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and obese subjects.

De Pergola G, Campobasso N, Nardecchia A, Triggiani V, Caccavo D, Gesualdo L, Silvestris F, Manno C - BMC Cardiovasc Disord (2015)

Bottom Line: Renal sinus fat (RSF) has been recognized as a risk factor for arterial hypertension.Ambulatory blood pressure monitoring (ABPM) was measured with 15 min intervals from 7.0 a.m. to 11.0 a.m. and with 30 min intervals from 23.0 to 7.0 for consecutive 24 h, starting from 8:30 AM.Measurement of para- and perirenal fat thickness was performed by ultrasounds by a duplex Doppler apparatus.

View Article: PubMed Central - PubMed

Affiliation: Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Sciences and Human Oncology, Section of Clinical Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy. gdepergola@libero.it.

ABSTRACT

Background: Renal sinus fat (RSF) has been recognized as a risk factor for arterial hypertension. This study was addressed to examine whether also para- and perirenal fat accumulation is associated to higher 24-h mean systolic (SBP) and/or diastolic blood pressure (DBP) levels in overweight and obese subjects.

Methods: A cohort of 42 overweight and obese patients, 29 women and 13 men, aged 25-55 years, not treated with any kind of drug, was examined. Body mass index (BMI), waist circumference (WC), fasting insulin and glucose serum levels, insulin resistance (assessed by using the homeostasis model assessment [HOMAIR]), and 24-h aldosterone urine levels were measured. Ambulatory blood pressure monitoring (ABPM) was measured with 15 min intervals from 7.0 a.m. to 11.0 a.m. and with 30 min intervals from 23.0 to 7.0 for consecutive 24 h, starting from 8:30 AM. Measurement of para- and perirenal fat thickness was performed by ultrasounds by a duplex Doppler apparatus.

Results: Para- and perirenal ultrasonographic fat thickness (PUFT) was significantly and positively correlated with WC (p < 0.01), insulin (p < 0.01), HOMAIR (p < 0.01), and 24-h mean DBP levels (p < 0.05). 24-h mean DBP was also significantly and positively correlated with 24-h aldosterone urine concentrations (p < 0.001). A multivariate analysis by multiple linear regression was performed; the final model showed that the association of 24-h mean DBP as dependent variable with PUFT (multiple R = 0.34; p = 0.026) and daily aldosterone production (multiple R = 0.59; p = 0.001) was independent of other anthropometric, hormone and metabolic parameters.

Discussion and conclusions: This study shows a positive independent association between PUFT and mean 24-h diastolic blood pressure levels in overweight and obese subjects, suggesting a possible direct role of PUFT in increasing daily diastolic blood pressure.

No MeSH data available.


Related in: MedlinePlus

PUFT = para- and perirenal ultrasonographic fat thickness
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Fig1: PUFT = para- and perirenal ultrasonographic fat thickness

Mentions: Measurement of PUFT was performed as previously described by our group [8], and ultrasound examinations were performed by a duplex Doppler apparatus (Acuson Sequoia 512 ultrasound system, Siemens, USA). PUFT was measured with the patient in the supine position. The probe was kept perpendicular to the skin on the lateral aspect of the abdomen. Longitudinal scanning was performed, and the probe was slowly moved laterally until the optimal position was found, at which the surface of the kidney was almost parallel to the skin. The pressure exerted on the probe was as minimal as possible so that the fat layers were not compressed. Then, the ultrasound thickness of para- and perirenal fat was measured from the inner side of the abdominal musculature to the surface of the kidney, and the average of the ultrasound measurement of the maximal thickness values on both sides was defined as the PUFT. The correlation between PUFT values measured on both sides was 0.749 (P < 0.0001). PUFT was measured three times. The intraoperator coefficient of variation was 4.5 %. Sonographer (N.C.) was blinded to any other aspect of the study. An ultrasound image of PUFT is shown in Fig. 1.Fig. 1


Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and obese subjects.

De Pergola G, Campobasso N, Nardecchia A, Triggiani V, Caccavo D, Gesualdo L, Silvestris F, Manno C - BMC Cardiovasc Disord (2015)

PUFT = para- and perirenal ultrasonographic fat thickness
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4588871&req=5

Fig1: PUFT = para- and perirenal ultrasonographic fat thickness
Mentions: Measurement of PUFT was performed as previously described by our group [8], and ultrasound examinations were performed by a duplex Doppler apparatus (Acuson Sequoia 512 ultrasound system, Siemens, USA). PUFT was measured with the patient in the supine position. The probe was kept perpendicular to the skin on the lateral aspect of the abdomen. Longitudinal scanning was performed, and the probe was slowly moved laterally until the optimal position was found, at which the surface of the kidney was almost parallel to the skin. The pressure exerted on the probe was as minimal as possible so that the fat layers were not compressed. Then, the ultrasound thickness of para- and perirenal fat was measured from the inner side of the abdominal musculature to the surface of the kidney, and the average of the ultrasound measurement of the maximal thickness values on both sides was defined as the PUFT. The correlation between PUFT values measured on both sides was 0.749 (P < 0.0001). PUFT was measured three times. The intraoperator coefficient of variation was 4.5 %. Sonographer (N.C.) was blinded to any other aspect of the study. An ultrasound image of PUFT is shown in Fig. 1.Fig. 1

Bottom Line: Renal sinus fat (RSF) has been recognized as a risk factor for arterial hypertension.Ambulatory blood pressure monitoring (ABPM) was measured with 15 min intervals from 7.0 a.m. to 11.0 a.m. and with 30 min intervals from 23.0 to 7.0 for consecutive 24 h, starting from 8:30 AM.Measurement of para- and perirenal fat thickness was performed by ultrasounds by a duplex Doppler apparatus.

View Article: PubMed Central - PubMed

Affiliation: Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Sciences and Human Oncology, Section of Clinical Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy. gdepergola@libero.it.

ABSTRACT

Background: Renal sinus fat (RSF) has been recognized as a risk factor for arterial hypertension. This study was addressed to examine whether also para- and perirenal fat accumulation is associated to higher 24-h mean systolic (SBP) and/or diastolic blood pressure (DBP) levels in overweight and obese subjects.

Methods: A cohort of 42 overweight and obese patients, 29 women and 13 men, aged 25-55 years, not treated with any kind of drug, was examined. Body mass index (BMI), waist circumference (WC), fasting insulin and glucose serum levels, insulin resistance (assessed by using the homeostasis model assessment [HOMAIR]), and 24-h aldosterone urine levels were measured. Ambulatory blood pressure monitoring (ABPM) was measured with 15 min intervals from 7.0 a.m. to 11.0 a.m. and with 30 min intervals from 23.0 to 7.0 for consecutive 24 h, starting from 8:30 AM. Measurement of para- and perirenal fat thickness was performed by ultrasounds by a duplex Doppler apparatus.

Results: Para- and perirenal ultrasonographic fat thickness (PUFT) was significantly and positively correlated with WC (p < 0.01), insulin (p < 0.01), HOMAIR (p < 0.01), and 24-h mean DBP levels (p < 0.05). 24-h mean DBP was also significantly and positively correlated with 24-h aldosterone urine concentrations (p < 0.001). A multivariate analysis by multiple linear regression was performed; the final model showed that the association of 24-h mean DBP as dependent variable with PUFT (multiple R = 0.34; p = 0.026) and daily aldosterone production (multiple R = 0.59; p = 0.001) was independent of other anthropometric, hormone and metabolic parameters.

Discussion and conclusions: This study shows a positive independent association between PUFT and mean 24-h diastolic blood pressure levels in overweight and obese subjects, suggesting a possible direct role of PUFT in increasing daily diastolic blood pressure.

No MeSH data available.


Related in: MedlinePlus