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Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.

Lillycrop KA, Costello PM, Teh AL, Murray RJ, Clarke-Harris R, Barton SJ, Garratt ES, Ngo S, Sheppard AM, Wong J, Dogra S, Burdge GC, Cooper C, Inskip HM, Gale CR, Gluckman PD, Harvey NC, Chong YS, Yap F, Meaney MJ, Rifkin-Graboi A, Holbrook JD, Epigen Global Research ConsortiumGodfrey KM - Int J Epidemiol (2015)

Bottom Line: Consistent with these findings, higher HES1 methylation was associated with higher executive memory function in a second independent group of 200 SWS 7-year-olds.Here, HES1 DMROI methylation predicted differences in early infant behaviour, known to be associated with academic success.Thus, our findings suggest that perinatal epigenetic processes mark later neurocognitive function and behaviour, providing support for a role of epigenetic processes in mediating the long-term consequences of early life environment on cognitive development.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biological Sciences, and NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK, kal@soton.ac.uk.

No MeSH data available.


Overview of study.
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dyv052-F1: Overview of study.

Mentions: Genomic umbilical cord DNA from 24 SWS children was screened using the MBD array for differences in DNA methylation at birth associated with WPPSI IQ age 4 years (Figure 1). The subjects selected were representative of the range of WPPSI IQ measurements within the whole cohort. Statistical analysis of the data identified 41 DMROIs associated with IQ at age 4 years (Supplementary Table 4, available as Supplementary data at IJE online; Figure 2a).Figure 1.


Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.

Lillycrop KA, Costello PM, Teh AL, Murray RJ, Clarke-Harris R, Barton SJ, Garratt ES, Ngo S, Sheppard AM, Wong J, Dogra S, Burdge GC, Cooper C, Inskip HM, Gale CR, Gluckman PD, Harvey NC, Chong YS, Yap F, Meaney MJ, Rifkin-Graboi A, Holbrook JD, Epigen Global Research ConsortiumGodfrey KM - Int J Epidemiol (2015)

Overview of study.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588869&req=5

dyv052-F1: Overview of study.
Mentions: Genomic umbilical cord DNA from 24 SWS children was screened using the MBD array for differences in DNA methylation at birth associated with WPPSI IQ age 4 years (Figure 1). The subjects selected were representative of the range of WPPSI IQ measurements within the whole cohort. Statistical analysis of the data identified 41 DMROIs associated with IQ at age 4 years (Supplementary Table 4, available as Supplementary data at IJE online; Figure 2a).Figure 1.

Bottom Line: Consistent with these findings, higher HES1 methylation was associated with higher executive memory function in a second independent group of 200 SWS 7-year-olds.Here, HES1 DMROI methylation predicted differences in early infant behaviour, known to be associated with academic success.Thus, our findings suggest that perinatal epigenetic processes mark later neurocognitive function and behaviour, providing support for a role of epigenetic processes in mediating the long-term consequences of early life environment on cognitive development.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biological Sciences, and NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK, kal@soton.ac.uk.

No MeSH data available.