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DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring.

Küpers LK, Xu X, Jankipersadsing SA, Vaez A, la Bastide-van Gemert S, Scholtens S, Nolte IM, Richmond RC, Relton CL, Felix JF, Duijts L, van Meurs JB, Tiemeier H, Jaddoe VW, Wang X, Corpeleijn E, Snieder H - Int J Epidemiol (2015)

Bottom Line: We found 35 differentially methylated CpGs (FDR < 0.05) in newborns exposed vs unexposed to smoking, of which 23 survived Bonferroni correction (P < 1 × 10(-7)).These CpGs partly mediated the effect of maternal smoking on birthweight (Sobel P < 0.05) in meta-analysis of GECKO and the two replication cohorts.Functional network analysis suggested a role in activating the immune system.

View Article: PubMed Central - PubMed

Affiliation: Departments of Epidemiology, l.k.kupers@umcg.nl.

No MeSH data available.


Related in: MedlinePlus

Volcano plot showing methylation differences between exposed and unexposed against –log10 of the P-values.
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dyv048-F2: Volcano plot showing methylation differences between exposed and unexposed against –log10 of the P-values.

Mentions: The volcano plot in Figure 2 shows the methylation differences between the exposed and unexposed groups plotted against statistical significance. It shows the 35 differentially methylated CpGs (FDR < 0.05) and the 23 CpGs that remained statistically significant after Bonferroni correction.Figure 2.


DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring.

Küpers LK, Xu X, Jankipersadsing SA, Vaez A, la Bastide-van Gemert S, Scholtens S, Nolte IM, Richmond RC, Relton CL, Felix JF, Duijts L, van Meurs JB, Tiemeier H, Jaddoe VW, Wang X, Corpeleijn E, Snieder H - Int J Epidemiol (2015)

Volcano plot showing methylation differences between exposed and unexposed against –log10 of the P-values.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588868&req=5

dyv048-F2: Volcano plot showing methylation differences between exposed and unexposed against –log10 of the P-values.
Mentions: The volcano plot in Figure 2 shows the methylation differences between the exposed and unexposed groups plotted against statistical significance. It shows the 35 differentially methylated CpGs (FDR < 0.05) and the 23 CpGs that remained statistically significant after Bonferroni correction.Figure 2.

Bottom Line: We found 35 differentially methylated CpGs (FDR < 0.05) in newborns exposed vs unexposed to smoking, of which 23 survived Bonferroni correction (P < 1 × 10(-7)).These CpGs partly mediated the effect of maternal smoking on birthweight (Sobel P < 0.05) in meta-analysis of GECKO and the two replication cohorts.Functional network analysis suggested a role in activating the immune system.

View Article: PubMed Central - PubMed

Affiliation: Departments of Epidemiology, l.k.kupers@umcg.nl.

No MeSH data available.


Related in: MedlinePlus