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Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

Tobi EW, Slieker RC, Stein AD, Suchiman HE, Slagboom PE, van Zwet EW, Heijmans BT, Lumey LH - Int J Epidemiol (2015)

Bottom Line: The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring.Famine exposure during gestation weeks 1-10, but not weeks 11-20, 21-30 or 31-delivery, was associated with an increase in DNA methylation of CpG dinucleotides cg20823026 (FAM150B), cg10354880 (SLC38A2) and cg27370573 (PPAP2C) and a decrease of cg11496778 (OSBPL5/MRGPRG) (P < 5.9 × 10(-7), PFDR < 0.031).These changes represent a shift of 0.3-0.6 standard deviations and are linked to genes involved in growth, development and metabolism.

View Article: PubMed Central - PubMed

Affiliation: Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

No MeSH data available.


Related in: MedlinePlus

Manhattan plot of specific CpG associations with prenatal famine exposure during weeks 1–10 of gestation. Shown are the −log10 P-values (y-axis) of the association between DNA methylation at single CpG dinucleotides and famine exposure along the autosomal chromosomes (x-axis). Marked by the CpG dinucleotide identifier are the CpG dinucleotides significant after multiple testing. These and adjacent nominally significant CpG dinucleotides are depicted as black diamonds.
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dyv043-F2: Manhattan plot of specific CpG associations with prenatal famine exposure during weeks 1–10 of gestation. Shown are the −log10 P-values (y-axis) of the association between DNA methylation at single CpG dinucleotides and famine exposure along the autosomal chromosomes (x-axis). Marked by the CpG dinucleotide identifier are the CpG dinucleotides significant after multiple testing. These and adjacent nominally significant CpG dinucleotides are depicted as black diamonds.

Mentions: Four CpG dinucleotides (cg20823026, cg11496778, cg10354880 and cg27370573) were associated with famine exposure in weeks 1–10 of gestation after multiple testing correction (PFDR < 0.031, Figure 2). No association was found for these CpG dinucleotides in any of the other exposure periods (Table 2). The effect sizes did not change after further adjustment for variables that could potentially mediate the effects of prenatal nutrition on DNA methylation, including current lifestyle factors such as smoking and dietary characteristics and SES.Figure 2.


Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

Tobi EW, Slieker RC, Stein AD, Suchiman HE, Slagboom PE, van Zwet EW, Heijmans BT, Lumey LH - Int J Epidemiol (2015)

Manhattan plot of specific CpG associations with prenatal famine exposure during weeks 1–10 of gestation. Shown are the −log10 P-values (y-axis) of the association between DNA methylation at single CpG dinucleotides and famine exposure along the autosomal chromosomes (x-axis). Marked by the CpG dinucleotide identifier are the CpG dinucleotides significant after multiple testing. These and adjacent nominally significant CpG dinucleotides are depicted as black diamonds.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588866&req=5

dyv043-F2: Manhattan plot of specific CpG associations with prenatal famine exposure during weeks 1–10 of gestation. Shown are the −log10 P-values (y-axis) of the association between DNA methylation at single CpG dinucleotides and famine exposure along the autosomal chromosomes (x-axis). Marked by the CpG dinucleotide identifier are the CpG dinucleotides significant after multiple testing. These and adjacent nominally significant CpG dinucleotides are depicted as black diamonds.
Mentions: Four CpG dinucleotides (cg20823026, cg11496778, cg10354880 and cg27370573) were associated with famine exposure in weeks 1–10 of gestation after multiple testing correction (PFDR < 0.031, Figure 2). No association was found for these CpG dinucleotides in any of the other exposure periods (Table 2). The effect sizes did not change after further adjustment for variables that could potentially mediate the effects of prenatal nutrition on DNA methylation, including current lifestyle factors such as smoking and dietary characteristics and SES.Figure 2.

Bottom Line: The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring.Famine exposure during gestation weeks 1-10, but not weeks 11-20, 21-30 or 31-delivery, was associated with an increase in DNA methylation of CpG dinucleotides cg20823026 (FAM150B), cg10354880 (SLC38A2) and cg27370573 (PPAP2C) and a decrease of cg11496778 (OSBPL5/MRGPRG) (P < 5.9 × 10(-7), PFDR < 0.031).These changes represent a shift of 0.3-0.6 standard deviations and are linked to genes involved in growth, development and metabolism.

View Article: PubMed Central - PubMed

Affiliation: Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

No MeSH data available.


Related in: MedlinePlus