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Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.

Sharp GC, Lawlor DA, Richmond RC, Fraser A, Simpkin A, Suderman M, Shihab HA, Lyttleton O, McArdle W, Ring SM, Gaunt TR, Davey Smith G, Relton CL - Int J Epidemiol (2015)

Bottom Line: There were no consistent associations of gestational weight gain with offspring DNA methylation.Our data suggest that both maternal obesity and, to a larger degree, underweight affect the neonatal epigenome via an intrauterine mechanism, but weight gain during pregnancy has little effect.We found some evidence that associations of maternal underweight with lower offspring adiposity and maternal obesity with greater offspring adiposity may be mediated via increased DNA methylation.

View Article: PubMed Central - PubMed

Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK, School of Social and Community Medicine, University of Bristol, Bristol, UK and gemma.sharp@bristol.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Associations between maternal or paternal obesity and offspring cord blood DNA methylation [mean difference in methylation (%) compared with offspring of normal weight mothers/fathers]. Darker shading indicates a larger effect size (regardless of direction). Models were adjusted for bisulfite conversion batch, and paternal/maternal continuous BMI where indicated, but no other covariates (n obese mothers = 40, n normal weight mothers = 665, n obese fathers = 53, n normal weight fathers = 372). Stars indicate associations with an FDR-adjusted P-value < 0.05.
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dyv042-F3: Associations between maternal or paternal obesity and offspring cord blood DNA methylation [mean difference in methylation (%) compared with offspring of normal weight mothers/fathers]. Darker shading indicates a larger effect size (regardless of direction). Models were adjusted for bisulfite conversion batch, and paternal/maternal continuous BMI where indicated, but no other covariates (n obese mothers = 40, n normal weight mothers = 665, n obese fathers = 53, n normal weight fathers = 372). Stars indicate associations with an FDR-adjusted P-value < 0.05.

Mentions: Associations of maternal obesity with offspring cord blood methylation were of greater magnitude than associations of paternal obesity with offspring cord blood methylation at all 28 sites identified through EWAS as associated with maternal obesity (Figure 3). The maternal associations remained stronger than paternal associations after mutual adjustment of maternal and paternal BMI. There was only one underweight father, so we were unable to compare the effect of maternal and paternal underweight.Figure 3.


Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.

Sharp GC, Lawlor DA, Richmond RC, Fraser A, Simpkin A, Suderman M, Shihab HA, Lyttleton O, McArdle W, Ring SM, Gaunt TR, Davey Smith G, Relton CL - Int J Epidemiol (2015)

Associations between maternal or paternal obesity and offspring cord blood DNA methylation [mean difference in methylation (%) compared with offspring of normal weight mothers/fathers]. Darker shading indicates a larger effect size (regardless of direction). Models were adjusted for bisulfite conversion batch, and paternal/maternal continuous BMI where indicated, but no other covariates (n obese mothers = 40, n normal weight mothers = 665, n obese fathers = 53, n normal weight fathers = 372). Stars indicate associations with an FDR-adjusted P-value < 0.05.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588865&req=5

dyv042-F3: Associations between maternal or paternal obesity and offspring cord blood DNA methylation [mean difference in methylation (%) compared with offspring of normal weight mothers/fathers]. Darker shading indicates a larger effect size (regardless of direction). Models were adjusted for bisulfite conversion batch, and paternal/maternal continuous BMI where indicated, but no other covariates (n obese mothers = 40, n normal weight mothers = 665, n obese fathers = 53, n normal weight fathers = 372). Stars indicate associations with an FDR-adjusted P-value < 0.05.
Mentions: Associations of maternal obesity with offspring cord blood methylation were of greater magnitude than associations of paternal obesity with offspring cord blood methylation at all 28 sites identified through EWAS as associated with maternal obesity (Figure 3). The maternal associations remained stronger than paternal associations after mutual adjustment of maternal and paternal BMI. There was only one underweight father, so we were unable to compare the effect of maternal and paternal underweight.Figure 3.

Bottom Line: There were no consistent associations of gestational weight gain with offspring DNA methylation.Our data suggest that both maternal obesity and, to a larger degree, underweight affect the neonatal epigenome via an intrauterine mechanism, but weight gain during pregnancy has little effect.We found some evidence that associations of maternal underweight with lower offspring adiposity and maternal obesity with greater offspring adiposity may be mediated via increased DNA methylation.

View Article: PubMed Central - PubMed

Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK, School of Social and Community Medicine, University of Bristol, Bristol, UK and gemma.sharp@bristol.ac.uk.

No MeSH data available.


Related in: MedlinePlus