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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ - Int J Epidemiol (2015)

Bottom Line: All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years.Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration).However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK, Queensland Brain Institute, and.

No MeSH data available.


Epigenome-wide association study Manhattan plots for the four fitness traits. The lines indicate the Bonferroni significant P-value threshold (P = 0.05/450,726 = 1.1 x 10−7) and nominal significance (P = 1 x 10−5). gf, fluid type general intelligence; FEV1, forced expiratory volume in one second.
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dyu277-F2: Epigenome-wide association study Manhattan plots for the four fitness traits. The lines indicate the Bonferroni significant P-value threshold (P = 0.05/450,726 = 1.1 x 10−7) and nominal significance (P = 1 x 10−5). gf, fluid type general intelligence; FEV1, forced expiratory volume in one second.

Mentions: Manhattan plots from the epigenome-wide association studies (EWAS) analyses are shown for the four fitness traits in Figure 2. No probes passed the Bonferroni significance threshold for any of the traits. A list of suggestive hits at the P < 1 x 10−5 significance threshold are listed in Supplementary Table 2 (available as Supplementary data at IJE online).Figure 2.


The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ - Int J Epidemiol (2015)

Epigenome-wide association study Manhattan plots for the four fitness traits. The lines indicate the Bonferroni significant P-value threshold (P = 0.05/450,726 = 1.1 x 10−7) and nominal significance (P = 1 x 10−5). gf, fluid type general intelligence; FEV1, forced expiratory volume in one second.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588858&req=5

dyu277-F2: Epigenome-wide association study Manhattan plots for the four fitness traits. The lines indicate the Bonferroni significant P-value threshold (P = 0.05/450,726 = 1.1 x 10−7) and nominal significance (P = 1 x 10−5). gf, fluid type general intelligence; FEV1, forced expiratory volume in one second.
Mentions: Manhattan plots from the epigenome-wide association studies (EWAS) analyses are shown for the four fitness traits in Figure 2. No probes passed the Bonferroni significance threshold for any of the traits. A list of suggestive hits at the P < 1 x 10−5 significance threshold are listed in Supplementary Table 2 (available as Supplementary data at IJE online).Figure 2.

Bottom Line: All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years.Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration).However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK, Queensland Brain Institute, and.

No MeSH data available.