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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ - Int J Epidemiol (2015)

Bottom Line: All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years.Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration).However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK, Queensland Brain Institute, and.

No MeSH data available.


Individual trajectories and mean rate of change in DNA methylation age over time.
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dyu277-F1: Individual trajectories and mean rate of change in DNA methylation age over time.

Mentions: Details of the LBC1936 cohort are presented in Table 1. Of the 1091 subjects included in the cohort, the mean age at baseline was 69.5 [standard deviation (SD) 0.8] years, and 49.8% were female. The mean DNA methylation age was 65.9 (SD 6.5) years. At waves 2 and 3, the mean ages were 72.5 (SD 0.7) and 76.2 (SD 0.7) years, and the mean DNA methylation ages were 67.2 (SD 6.7) and 71.5 (SD 6.2) years, respectively. Individual trajectories and the mean rate of change in DNA methylation age are plotted in Figure 1. The fitness variables are also presented in Table 1 across the three waves. The mean fluid-intelligence cognitive score at baseline was 0.05 (SD 1.01), which declined at waves 2 (mean 0.03) and 3 (mean −0.07). Decline was also observed for grip strength and lung function across the three waves. Walking speed decreased over the waves, taking 3.9 s to walk 6 m at wave 1 compared with 4.7 s at wave 3.Compared with the participants with methylation data who completed more than one wave, those with methylation data from the first time point were slightly older with lower cognitive scores, poorer fitness scores and a higher methylation age (Supplementary Table 1, available as Supplementary data at IJE online).Figure 1.


The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ - Int J Epidemiol (2015)

Individual trajectories and mean rate of change in DNA methylation age over time.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588858&req=5

dyu277-F1: Individual trajectories and mean rate of change in DNA methylation age over time.
Mentions: Details of the LBC1936 cohort are presented in Table 1. Of the 1091 subjects included in the cohort, the mean age at baseline was 69.5 [standard deviation (SD) 0.8] years, and 49.8% were female. The mean DNA methylation age was 65.9 (SD 6.5) years. At waves 2 and 3, the mean ages were 72.5 (SD 0.7) and 76.2 (SD 0.7) years, and the mean DNA methylation ages were 67.2 (SD 6.7) and 71.5 (SD 6.2) years, respectively. Individual trajectories and the mean rate of change in DNA methylation age are plotted in Figure 1. The fitness variables are also presented in Table 1 across the three waves. The mean fluid-intelligence cognitive score at baseline was 0.05 (SD 1.01), which declined at waves 2 (mean 0.03) and 3 (mean −0.07). Decline was also observed for grip strength and lung function across the three waves. Walking speed decreased over the waves, taking 3.9 s to walk 6 m at wave 1 compared with 4.7 s at wave 3.Compared with the participants with methylation data who completed more than one wave, those with methylation data from the first time point were slightly older with lower cognitive scores, poorer fitness scores and a higher methylation age (Supplementary Table 1, available as Supplementary data at IJE online).Figure 1.

Bottom Line: All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years.Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration).However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK, Queensland Brain Institute, and.

No MeSH data available.